DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and GRID1

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	680	Identity:	141/680 - (20%)
Similarity:	236/680 - (34%)	Gaps:	196/680 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ILHCSLSHLALLAQSKNIFTQFQPLHSDIQ---LNDDFLNHNILKLGVFLDINCDKSGTVLDMAS 84
            ::|.:|..:.::.|   ||    |...|.|   .|    ||.|..|      .||.....|.|..
Human   270 LVHSALGRMTVVRQ---IF----PSAKDNQKCTRN----NHRISSL------LCDPQEGYLQMLQ 317

  Fly    85 AKRFF--------SHRYHWLIYD----------------------RSMNFSVLESH--------- 110
            ....:        ::.:|..:.|                      |||..::.:.|
Human   318 ISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVME 382

  Fly   111 FKE--AQIFVDADVTYVTH-DPFSKNFLLYDVYNKGRQLGGELNITADREIFCNKTNCRVERYLS 172
            |:|  :..:|..::...|: :.|.|:......::..:.|.|.|.                ||.:.
Human   383 FREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQ----------------ERPMG 431

  Fly   173 ELYTRSALQHRKSFTGLTMRATAVVTAL--PLNVSIKEIFDFMNSKYRIQLDTYARLGYQARQPL 235
                 |.||      |||::   |||.|  |..:..:.|                 ||    ||.
Human   432 -----SRLQ------GLTLK---VVTVLEEPFVMVAENI-----------------LG----QPK 461

  Fly   236 R------DMLDC-----KFKY-------------IFRDRWSDGNATGGMIGDLILDKADLAIAPF 276
            |      |:||.     .|||             :....|:      ||||:||..:|||||:..
Human   462 RYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWN------GMIGELISKRADLAISAI 520

  Fly   277 IYSFDRALFLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWV 341
            ..:.:|...:....::..:....:.:.|..   .:|......||...||...|..:.:.|.|:
Human   521 TITPERESVVDFSKRYMDYSVGILIKKPEE---KISIFSLFAPFDFAVWACIAAAIPVVGVLI-- 580

  Fly   342 TFILER--------RKQWKPS----LLTSCLLSFGAGCIQGAWLTPRSMGGRMA-----FFALMV 389
             |:|.|        ..|.:||    |.::..:.:||...||...:..||..|:.     .|.|:|
Human   581 -FVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIV 644

  Fly   390 TSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADS-NLDVGI--EPTVYTRIYVE----TSEEPD 447
            .|....|....:.||::     .:.|||.|.|:.. .:..|.  :..||.....:    ..::..
Human   645 CSSYTANLAAFLTVSRM-----DNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDST 704

  Fly   448 VRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEIP 512
            ..:|:|  .:......|........|:...: :..:.::..||.    |....|....|.:..|.
Human   705 FAELWR--TISKNGGADNCVSSPSEGIRKAK-KGNYAFLWDVAV----VEYAALTDDDCSVTVIG 762

  Fly   513 LRDASHTHTV-LAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTVA------VG 570
            ...:|..:.: |...|||.:|.....|.:.:||.....::.|......|...:|..|      :.
Human   763 NSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLK 827

  Fly   571 LEYAAPLFIIL-LGAIILCMGILGLEVIWH 599
            |...|.:|.|| :|.::.|: :..||:.|:
Human   828 LHSFAGVFCILAIGLLLACL-VAALELWWN 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	69/324 (21%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	58/273 (21%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		37/209 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	30/169 (18%)
		ANF_receptor	41..400	CDD:279440	26/146 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	91/417 (22%)
		Lig_chan	564..841	CDD:278489	62/291 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155853
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740