Protein Alignment Ir75b and GRIA4

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_000820.4
• Gene: GRIA4 / 2893
• HGNCID: 4574
• Length: 902
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 119/523 - (22%)
• Similarity: 203/523 - (38%)
• Gaps: 114/523 - (21%)

  Fly   137 YDVYNKGRQLGGELNITADREIF-CNKTNCRVERYLSELYTRSALQHRKSF---TGLTMRATAVV 197
            :|.|      |..:|.|.|  :| ...|..|...|.:::.....:|...:.   |......|.||
Human   363 FDHY------GRRVNYTMD--VFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVV 419

  Fly   198 TAL---PLNVSIK--EIFDFMNSKYRIQLDTYARLGY--QARQPLRDMLDCKF--------KYIF 247
            |.:   |..:..|  |:|: .|.||.         ||  .....:...:..|:        ||..
Human   420 TTIMESPYVMYKKNHEMFE-GNDKYE---------GYCVDLASEIAKHIGIKYKIAIVPDGKYGA 474

  Fly   248 RDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRAL---FLQPITKFSVFREICMFRNPRSVSA 309
            ||  :|.....||:|:|:..||::||||...:..|..   |.:|.....:   ..|.:.|:....
Human   475 RD--ADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGI---SIMIKKPQKSKP 534

  Fly   310 GLSATEFLQPFSGGVWLTFALLLLLAGCLLW-------VTFILERRK--QWK----------PS- 354
            |:.:  ||.|.:..:|:          |:::       |.|::.|..  :|.          ||
Human   535 GVFS--FLDPLAYEIWM----------CIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSD 587

  Fly   355 -------LLTSCLLSFGAGCIQGAWLTPRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLL 407
                   :..|...|.||...||..::|||:.||:.     ||.|::.|....|....:.|.:::
Human   588 QPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 652

  Fly   408 GQPIKS--NIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPT 470
             .||:|  ::....::|...||.|.....:.|..:.         :|.|.....:.:...::..|
Human   653 -SPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA---------VYEKMWTYMRSAEPSVFTRT 707

  Fly   471 EA-GVLSVRDQEG-FVYITGVATGYEFVRKHFLAHQICELNEIPLR-DASHTHTVLAKRSPYAEL 532
            .| ||..||..:| |.::. .:|..|::.:    .:.|:..::... |:........|.|.....
Human   708 TAEGVARVRKSKGKFAFLL-ESTMNEYIEQ----RKPCDTMKVGGNLDSKGYGVATPKGSSLRTP 767

  Fly   533 IKLSELRMLETGVHFKHERSWMETKLHC-----YQHNHTVAVGLEYAAPLFIILLGAIILCMGIL 592
            :.|:.|::.|.||..|.:..|...|..|     ...:.|.|:.|...|.:|.||:|.:.|.|.:.
Human   768 VNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVA 832

  Fly   593 GLE 595
            .:|
Human   833 LIE 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	16/55 (29%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	19/68 (28%)
		Lig_chan	343..584	CDD:459656	62/275 (23%)
GRIA4	NP_000820.4	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	10/44 (23%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	95/422 (23%)