DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75b and GRIA4

DIOPT Version :9

Sequence 1:NP_001137966.2 Gene:Ir75b / 8673994 FlyBaseID:FBgn0261402 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_000820.4 Gene:GRIA4 / 2893 HGNCID:4574 Length:902 Species:Homo sapiens


Alignment Length:523 Identity:119/523 - (22%)
Similarity:203/523 - (38%) Gaps:114/523 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 YDVYNKGRQLGGELNITADREIF-CNKTNCRVERYLSELYTRSALQHRKSF---TGLTMRATAVV 197
            :|.|      |..:|.|.|  :| ...|..|...|.:::.....:|...:.   |......|.||
Human   363 FDHY------GRRVNYTMD--VFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVV 419

  Fly   198 TAL---PLNVSIK--EIFDFMNSKYRIQLDTYARLGY--QARQPLRDMLDCKF--------KYIF 247
            |.:   |..:..|  |:|: .|.||.         ||  .....:...:..|:        ||..
Human   420 TTIMESPYVMYKKNHEMFE-GNDKYE---------GYCVDLASEIAKHIGIKYKIAIVPDGKYGA 474

  Fly   248 RDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRAL---FLQPITKFSVFREICMFRNPRSVSA 309
            ||  :|.....||:|:|:..||::||||...:..|..   |.:|.....:   ..|.:.|:....
Human   475 RD--ADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGI---SIMIKKPQKSKP 534

  Fly   310 GLSATEFLQPFSGGVWLTFALLLLLAGCLLW-------VTFILERRK--QWK----------PS- 354
            |:.:  ||.|.:..:|:          |:::       |.|::.|..  :|.          || 
Human   535 GVFS--FLDPLAYEIWM----------CIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSD 587

  Fly   355 -------LLTSCLLSFGAGCIQGAWLTPRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLL 407
                   :..|...|.||...||..::|||:.||:.     ||.|::.|....|....:.|.:::
Human   588 QPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 652

  Fly   408 GQPIKS--NIRTLQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPT 470
             .||:|  ::....::|...||.|.....:.|..:.         :|.|.....:.:...::..|
Human   653 -SPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA---------VYEKMWTYMRSAEPSVFTRT 707

  Fly   471 EA-GVLSVRDQEG-FVYITGVATGYEFVRKHFLAHQICELNEIPLR-DASHTHTVLAKRSPYAEL 532
            .| ||..||..:| |.::. .:|..|::.:    .:.|:..::... |:........|.|.....
Human   708 TAEGVARVRKSKGKFAFLL-ESTMNEYIEQ----RKPCDTMKVGGNLDSKGYGVATPKGSSLRTP 767

  Fly   533 IKLSELRMLETGVHFKHERSWMETKLHC-----YQHNHTVAVGLEYAAPLFIILLGAIILCMGIL 592
            :.|:.|::.|.||..|.:..|...|..|     ...:.|.|:.|...|.:|.||:|.:.|.|.:.
Human   768 VNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVA 832

  Fly   593 GLE 595
            .:|
Human   833 LIE 835

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir75bNP_001137966.2 Periplasmic_Binding_Protein_Type_2 253..553 CDD:304360 75/339 (22%)
Lig_chan 343..585 CDD:278489 63/276 (23%)
GRIA4NP_000820.4 PBP1_iGluR_AMPA_GluR4 28..398 CDD:107383 10/42 (24%)
PBP2_iGluR_AMPA_GluR4 414..795 CDD:270445 95/422 (23%)
Glutamate binding. /evidence=ECO:0000250 500..502 1/1 (100%)