Protein Alignment Ir75b and GRIA3

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_000819.4
• Gene: GRIA3 / 2892
• HGNCID: 4573
• Length: 894
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 119/561 - (21%)
• Similarity: 204/561 - (36%)
• Gaps: 172/561 - (30%)

  Fly    94 HWLIYDRSMNFSVLESHFKEAQIFVDAD--------VTYVTHDPFSKNFLLYDVYNKG-RQLGGE 149
            :|..|:|.:.||       :.||..|:.        ||.:...|       |.:|.|. .||.|
Human   398 YWNEYERFVPFS-------DQQISNDSASSENRTIVVTTILESP-------YVMYKKNHEQLEG- 447

  Fly   150 LNITADREIFCNKTNCRVERYLSELYTRSALQHRKSFTGLTMRATAVVTALPLNVSIKEIFDFMN 214
                          |.|.|.|..:|                               ..||...:.
Human   448 --------------NERYEGYCVDL-------------------------------AYEIAKHVR 467

  Fly   215 SKYRIQLDTYARLG---YQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPF 276
            .||::.:     :|   |.||.|     :.|.       |:      ||:|:|:..:||:|:||.
Human   468 IKYKLSI-----VGDGKYGARDP-----ETKI-------WN------GMVGELVYGRADIAVAPL 509

  Fly   277 IYSFDRAL---FLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCL 338
            ..:..|..   |.:|.....:   ..|.:.|:....|:.:  ||.|.:..:|:          |:
Human   510 TITLVREEVIDFSKPFMSLGI---SIMIKKPQKSKPGVFS--FLDPLAYEIWM----------CI 559

  Fly   339 LW-------VTFILERRK--QW-------KP-------------SLLTSCLLSFGAGCIQGAWLT 374
            ::       |.|::.|..  :|       :|             .:..|...|.||...||..::
Human   560 VFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDIS 624

  Fly   375 PRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLLGQPIKS--NIRTLQQLADSNLDVGIEP 432
            |||:.||:.     ||.|::.|....|....:.|.::: .||:|  ::....::|...||.|...
Human   625 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAKQTEIAYGTLDSGSTK 688

  Fly   433 TVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEA-GVLSVRDQEG-FVYITGVATGYEF 495
            ..:.|..:.         :|.|.....|.:...::..|.| ||..||..:| |.::. .:|..|:
Human   689 EFFRRSKIA---------VYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLL-ESTMNEY 743

  Fly   496 VRKHFLAHQICELNEIPLR-DASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLH 559
            :.:    .:.|:..::... |:........|.|.....:.|:.|::.|.|:..|.:..|...|..
Human   744 IEQ----RKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE 804

  Fly   560 C-----YQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLE 595
            |     ...:.|.|:.|...|.:|.||:|.:.|.|.:..:|
Human   805 CGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIE 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	11/47 (23%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	18/68 (26%)
		Lig_chan	343..584	CDD:459656	61/277 (22%)
GRIA3	NP_000819.4	PBP1_iGluR_AMPA_GluR3	35..409	CDD:380610	3/10 (30%)
		PBP2_iGluR_AMPA	422..805	CDD:270433	99/488 (20%)