DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and Grin2d

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	93/409 - (22%)
Similarity:	155/409 - (37%)	Gaps:	109/409 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 GMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSV-FRE----ICMFRNPRSVS-------AGL 311
            ||||::...:||:||.....:.:|:    .|..||| |.|    :.:.|:..:||       |.|
  Rat   520 GMIGEVFYQRADMAIGSLTINEERS----EIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWL 580

  Fly   312 SATEFLQPFSGGVWLTFALLLLLAGCLLWV---TFILERRKQ--WKPSLLTSCL---LSFGAGCI 368
            :.....:|:|..||     :::...||..|   .||.|....  :..||.|...   .:|..|
  Rat   581 TPPMSPEPYSPAVW-----VMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIG-- 638

  Fly   369 QGAWL-------------TPRSMGGRM-----AFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNI 415
            :..||             .||....::     ||||::..:     .||:.:.:.::.:   ..:
  Rat   639 KSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLA-----SYTANLAAFMIQE---EYV 695

  Fly   416 RTLQQLADSN----------LDVGIEPTVYTRIYVETSEEPDVR----DLYRKKVLGSKRSPDKI 466
            .|:..|:|..          |..|..|        ..|.|.::|    |::...|..::...::.
  Rat   696 DTVSGLSDRKFQRPQEQYPPLKFGTVP--------NGSTEKNIRSNYPDMHSYMVRYNQPRVEEA 752

  Fly   467 WIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAH--QICELNEIPLRDASHT---HTVLAKR 526
            ....:||.|     :.|:|...|.        :::|.  :.|:|..|.......|   ...|.|.
  Rat   753 LTQLKAGKL-----DAFIYDAAVL--------NYMARKDEGCKLVTIGSGKVFATTGYGIALHKG 804

  Fly   527 SPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTVAV-----GLEYAAPLFIILLGAII 586
            |.:...|.|:.|:.|........||.|:..  .|  ||..:.|     .::..|.:|.:||.|:.
  Rat   805 SRWKRPIDLALLQFLGDDEIEMLERLWLSG--IC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMG 865

  Fly   587 LCMGILGLE--VIWH-RHC 602
            |.:.:...|  |.|. |||
  Rat   866 LSLLVFAWEHLVYWRLRHC 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	76/350 (22%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	58/288 (20%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	78/361 (22%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830