Protein Alignment Ir75b and Grin2a

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_036705.3
• Gene: Grin2a / 24409
• RGDID: 2737
• Length: 1464
• Species: Rattus norvegicus
• Alignment Length: 404
• Identity: 82/404 - (20%)
• Similarity: 142/404 - (35%)
• Gaps: 117/404 - (28%)

  Fly   255 NATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSV-FRE----ICMFRNPRSVSAGLSAT 314
            |...||||:::..:|.:|:.....:.:|:    .:..||| |.|    :.:.|:..:|    |.:
  Rat   491 NVWNGMIGEVVYQRAVMAVGSLTINEERS----EVVDFSVPFVETGISVMVSRSNGTV----SPS 547

  Fly   315 EFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKPSLLTSCLL--------SFGAGCIQGA 371
            .||:|||..||:...::||:...:  ..|:.|   .:.|......|.        ||..|  :..
  Rat   548 AFLEPFSASVWVMMFVMLLIVSAI--AVFVFE---YFSPVGYNRNLAKGKAPHGPSFTIG--KAI 605

  Fly   372 WL------------------TPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTL 418
            ||                  |.:.|....||||::..:....|....::..:.:.|....:.:..
  Rat   606 WLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKF 670

  Fly   419 QQLADSN--LDVGIEPT-----------VYTRIYVETSEEPDVRD-------------LYRKKVL 457
            |:..|.:  ...|..|.           .|...|:....:..|.|             :|...||
  Rat   671 QRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTGKLDAFIYDAAVL 735

  Fly   458 GSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEIPLRDASHTHTV 522
            ..|...|:       |...|....|:::.|   |||..                          .
  Rat   736 NYKAGRDE-------GCKLVTIGSGYIFAT---TGYGI--------------------------A 764

  Fly   523 LAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV---AVGLEYAAPLFIILLGA 584
            |.|.||:...|.|:.|:.:..|...:.|..|: |.: |:...:.|   .:.::..|.:|.:|..|
  Rat   765 LQKGSPWKRQIDLALLQFVGDGEMEELETLWL-TGI-CHNEKNEVMSSQLDIDNMAGVFYMLAAA 827

  Fly   585 IILCMGILGLEVIW 598
            :.|.:    :..||
  Rat   828 MALSL----ITFIW 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	7/27 (26%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	20/70 (29%)
		Lig_chan	343..584	CDD:459656	53/295 (18%)
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	74/363 (20%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1	599..620		4/22 (18%)
		NMDAR2_C	839..1464	CDD:463148
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464