DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75b and Grin2a

DIOPT Version :9

Sequence 1:NP_001137966.2 Gene:Ir75b / 8673994 FlyBaseID:FBgn0261402 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:404 Identity:82/404 - (20%)
Similarity:142/404 - (35%) Gaps:117/404 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   255 NATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSV-FRE----ICMFRNPRSVSAGLSAT 314
            |...||||:::..:|.:|:.....:.:|:    .:..||| |.|    :.:.|:..:|    |.:
  Rat   491 NVWNGMIGEVVYQRAVMAVGSLTINEERS----EVVDFSVPFVETGISVMVSRSNGTV----SPS 547

  Fly   315 EFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKPSLLTSCLL--------SFGAGCIQGA 371
            .||:|||..||:...::||:...:  ..|:.|   .:.|......|.        ||..|  :..
  Rat   548 AFLEPFSASVWVMMFVMLLIVSAI--AVFVFE---YFSPVGYNRNLAKGKAPHGPSFTIG--KAI 605

  Fly   372 WL------------------TPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTL 418
            ||                  |.:.|....||||::..:....|....::..:.:.|....:.:..
  Rat   606 WLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKF 670

  Fly   419 QQLADSN--LDVGIEPT-----------VYTRIYVETSEEPDVRD-------------LYRKKVL 457
            |:..|.:  ...|..|.           .|...|:....:..|.|             :|...||
  Rat   671 QRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTGKLDAFIYDAAVL 735

  Fly   458 GSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEIPLRDASHTHTV 522
            ..|...|:       |...|....|:::.|   |||..                          .
  Rat   736 NYKAGRDE-------GCKLVTIGSGYIFAT---TGYGI--------------------------A 764

  Fly   523 LAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV---AVGLEYAAPLFIILLGA 584
            |.|.||:...|.|:.|:.:..|...:.|..|: |.: |:...:.|   .:.::..|.:|.:|..|
  Rat   765 LQKGSPWKRQIDLALLQFVGDGEMEELETLWL-TGI-CHNEKNEVMSSQLDIDNMAGVFYMLAAA 827

  Fly   585 IILCMGILGLEVIW 598
            :.|.:    :..||
  Rat   828 MALSL----ITFIW 837

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir75bNP_001137966.2 Periplasmic_Binding_Protein_Type_2 253..553 CDD:304360 71/354 (20%)
Lig_chan 343..585 CDD:278489 53/296 (18%)
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 74/363 (20%)
HisJ <458..>541 CDD:223904 14/53 (26%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 57/316 (18%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 4/22 (18%)