DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and Grik5

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	154/686 - (22%)
Similarity:	257/686 - (37%)	Gaps:	170/686 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KLSHVLI-LHCSLSHLALLAQS---------KNIFT--QFQPLHSDIQLNDDFLNHNILKLGVF- 68
            |:|.::| .:.|:|||.|...|         |.|.|  .|..||.|..:.|   :.|||...:|
  Rat   210 KVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVED---SSNILGFSMFN 271

  Fly    69 ------------LDI----NCDKS---GTVLDMASAKRFFSHRYHWLIYD-------------RS 101
                        |::    ||:.|   |..|..|            |::|             ||
  Rat   272 TSHPFYPEFVRSLNMSWRENCEASTYPGPALSAA------------LMFDAVHVVVSAVRELNRS 324

  Fly   102 MNFSVLESHFKEAQIFVDADVTYVTHDPFSKNFLLYDVYN--KGRQLGGELNITADREIFCNKTN 164
            ....|.......|.|:        .|.....|:|....|:  .||.   |.|....|      ||
  Rat   325 QEIGVKPLACTSANIW--------PHGTSLMNYLRMVEYDGLTGRV---EFNSKGQR------TN 372

  Fly   165 CRVERYLSELYTRSALQHRKSFTGLTMRATAV-VTALPLNVS------IKEIFDFMNSKYRIQLD 222
                 |...:..:|...||:.....:.|..|: .|.|.:|:|      ...:...:.:.|.::..
  Rat   373 -----YTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRP 432

  Fly   223 TYARLGYQAR------QPLRDMLD-CKFKYIFR-------------DRWSDGNATGGMIGDLI-L 266
            .:..|....|      ..||::.: .:|:|..|             ..|:      ||:|:|| .
  Rat   433 NFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWT------GMVGELINR 491

  Fly   267 DKADLAIAPFIYSFDRAL---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWL 326
            .|||||:|.|..:.:|..   |.:|...  .|:...:.|.|.|...|       ||.|||..|||
  Rat   492 QKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS-------FLDPFSPAVWL 549

  Fly   327 TFALLLLLAGCLLWVTFILERRKQWKP---------------SLLTSCLLSFGAGCIQGAWLTPR 376
            ...|..|...|:|::...|...:.:.|               :|..|.....|....||:.:.||
  Rat   550 FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPR 614

  Fly   377 SMGGR------MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLAD-SNLDVGIEPTV 434
            ::..|      .||..::::|      ||:.:.:.|..|.::..:.:...||| :|::.|.....
  Rat   615 ALSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAG 673

  Fly   435 YTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKH 499
            .|..:.:.|.....:.::  ..:.||: |......||.|:..|.:.. :.::. .:|..|:.|:
  Rat   674 STMTFFQNSRYQTYQRMW--NYMQSKQ-PSVFVKSTEEGIARVLNSR-YAFLL-ESTMNEYHRR- 732

  Fly   500 FLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQH 563
                ..|.|.:| .|.|.......:...||:.:.|.|:.|::.|.......:|.|.|......:.
  Rat   733 ----LNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEE 793

  Fly   564 NHTV-AVGLEYAAPLFIILLGAIILCMGILGLEVIW 598
            :|.. .:|:|....:|::|:..:|:.:.:..:|.||
  Rat   794 DHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	78/328 (24%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	53/265 (20%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	52/227 (23%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	88/399 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349848
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740