DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and Grik4

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	692	Identity:	152/692 - (21%)
Similarity:	257/692 - (37%)	Gaps:	176/692 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LIHM-AKLSHVLILHCSLSHLALL-AQSKNIFTQFQPLHSDIQLNDDFLNH--NILKLGVFLDIN 72
            :||. |.:||.::|  ..:.|.:: |....|||.   |...:|..|..::.  |||...:|
  Rat   216 IIHANASMSHTILL--KAAELGMVSAYYTYIFTN---LEFSLQRMDSLVDDRVNILGFSIF---- 271

  Fly    73 CDKSGTVLDMASAKRFFSHRYHWLIYDRSMNFSVLESHFKEAQIFVDADVTYVTHDPFS----KN 133
                      ..:..||..      :.:|:|.|..|:               ..|.||:    .:
  Rat   272 ----------NQSHAFFQE------FSQSLNQSWQEN---------------CDHVPFTGPALSS 305

  Fly   134 FLLYD-VY---------NKGRQLGGELNITADREIFCNKTNCRVERYLSEL-------------- 174
            .||:| ||         |:.:::|.:.......:|:.:.|:......:.||
  Rat   306 ALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQ 370

  Fly   175 ---YTRSALQH-RKSF---------TGLTM--------------RATAVVTALPLN--VSIKEIF 210
               |....||. |..|         .||:|              ..|.|||.:..|  :.:|...
  Rat   371 RSNYALKILQFTRNGFRQIGQWHVAEGLSMDSRLYASNISDSLFNTTLVVTTILENPYLMLKGNH 435

  Fly   211 DFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDG-----NATG---GMIGDLILD 267
            ..|...     |.|........:.|.::|  :|.|..| ...||     .|.|   ||:|:||..
  Rat   436 QDMEGN-----DRYEGFCVDMLKELAEIL--RFNYKIR-LVGDGVYGVPEANGTWTGMVGELIAR 492

  Fly   268 KADLAIAPFIYSFDRAL---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLT 327
            |||||:|....:.:|..   |.:|...  .|:...:.|.|.|...|       ||.|||.||||.
  Rat   493 KADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFS-------FLDPFSPGVWLF 550

  Fly   328 FALLLLLAGCLLWVTFILERRKQWKP---------------SLLTSCLLSFGAGCIQGAWLTPRS 377
            ..|..|...|:|::...|...:.:.|               ||..|.....|....||:.:.||:
  Rat   551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRA 615

  Fly   378 MGGR------MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSN-LDVGIEPTVY 435
            :..|      .||..::::|      ||:.:.:.|..|.::..|.::..|||.. ::.|   |::
  Rat   616 LSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMEVPIESVDDLADQTAIEYG---TIH 671

  Fly   436 ---TRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVR 497
               :..:.:.|.....:.::  ..:.||: |......||.|:..|.: ..:.::      .|...
  Rat   672 GGSSMTFFQNSRYQTYQRMW--NYMYSKQ-PSVFVKSTEEGIARVLN-SNYAFL------LESTM 726

  Fly   498 KHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCY 561
            ..:...:.|.|.:| .|.|.......:...|.:.:...|:.|::.|.......:|.|.|......
  Rat   727 NEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPK 791

  Fly   562 QHNHTV-AVGLEYAAPLFIILLGAIILCMGILGLEVIWH-RH 601
            :.:|.. .:|:|....:|::|:..:|:.:.:..||.:|. ||
  Rat   792 EEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRH 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	79/338 (23%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	50/268 (19%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	46/225 (20%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	94/403 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740