Protein Alignment Ir75b and Grik4

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_036704.1
• Gene: Grik4 / 24406
• RGDID: 2734
• Length: 956
• Species: Rattus norvegicus
• Alignment Length: 692
• Identity: 152/692 - (21%)
• Similarity: 257/692 - (37%)
• Gaps: 176/692 - (25%)

  Fly    12 LIHM-AKLSHVLILHCSLSHLALL-AQSKNIFTQFQPLHSDIQLNDDFLNH--NILKLGVFLDIN 72
            :||. |.:||.::|  ..:.|.:: |....|||.   |...:|..|..::.  |||...:|
  Rat   216 IIHANASMSHTILL--KAAELGMVSAYYTYIFTN---LEFSLQRMDSLVDDRVNILGFSIF---- 271

  Fly    73 CDKSGTVLDMASAKRFFSHRYHWLIYDRSMNFSVLESHFKEAQIFVDADVTYVTHDPFS----KN 133
                      ..:..||..      :.:|:|.|..|:               ..|.||:    .:
  Rat   272 ----------NQSHAFFQE------FSQSLNQSWQEN---------------CDHVPFTGPALSS 305

  Fly   134 FLLYD-VY---------NKGRQLGGELNITADREIFCNKTNCRVERYLSEL-------------- 174
            .||:| ||         |:.:::|.:.......:|:.:.|:......:.||
  Rat   306 ALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQ 370

  Fly   175 ---YTRSALQH-RKSF---------TGLTM--------------RATAVVTALPLN--VSIKEIF 210
               |....||. |..|         .||:|              ..|.|||.:..|  :.:|...
  Rat   371 RSNYALKILQFTRNGFRQIGQWHVAEGLSMDSRLYASNISDSLFNTTLVVTTILENPYLMLKGNH 435

  Fly   211 DFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDG-----NATG---GMIGDLILD 267
            ..|...     |.|........:.|.::|  :|.|..| ...||     .|.|   ||:|:||..
  Rat   436 QDMEGN-----DRYEGFCVDMLKELAEIL--RFNYKIR-LVGDGVYGVPEANGTWTGMVGELIAR 492

  Fly   268 KADLAIAPFIYSFDRAL---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLT 327
            |||||:|....:.:|..   |.:|...  .|:...:.|.|.|...|       ||.|||.||||.
  Rat   493 KADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFS-------FLDPFSPGVWLF 550

  Fly   328 FALLLLLAGCLLWVTFILERRKQWKP---------------SLLTSCLLSFGAGCIQGAWLTPRS 377
            ..|..|...|:|::...|...:.:.|               ||..|.....|....||:.:.||:
  Rat   551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRA 615

  Fly   378 MGGR------MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSN-LDVGIEPTVY 435
            :..|      .||..::::|      ||:.:.:.|..|.::..|.::..|||.. ::.|   |::
  Rat   616 LSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMEVPIESVDDLADQTAIEYG---TIH 671

  Fly   436 ---TRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVR 497
               :..:.:.|.....:.::  ..:.||: |......||.|:..|.: ..:.::      .|...
  Rat   672 GGSSMTFFQNSRYQTYQRMW--NYMYSKQ-PSVFVKSTEEGIARVLN-SNYAFL------LESTM 726

  Fly   498 KHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCY 561
            ..:...:.|.|.:| .|.|.......:...|.:.:...|:.|::.|.......:|.|.|......
  Rat   727 NEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPK 791

  Fly   562 QHNHTV-AVGLEYAAPLFIILLGAIILCMGILGLEVIWH-RH 601
            :.:|.. .:|:|....:|::|:..:|:.:.:..||.:|. ||
  Rat   792 EEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRH 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	20/55 (36%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	25/70 (36%)
		Lig_chan	343..584	CDD:459656	50/267 (19%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	46/225 (20%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	94/403 (23%)
		QRL_CxxC_CxxC	863..927	CDD:469521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956