DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and Grin3a

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	811	Identity:	144/811 - (17%)
Similarity:	256/811 - (31%)	Gaps:	307/811 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LILHCSLSHLALLAQSKNIFTQ--FQPLHSDIQLND----------------------------- 55
            |.|..|:.|:.:|:..::.|.:  ..|||..:.|.:
Mouse   209 LDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQED 273

  Fly    56 ----DFL----NHNILKLGVFLDINCDKSGTV------------------------LDMASAKRF 88
                |||    |::...|...::|..:.|.|.                        .||.|.::.
Mouse   274 WNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQI 338

  Fly    89 F--SHRY-------HWLIYDRSMNF--------------------SVLESHFKEAQIFV------ 118
            |  |.::       ||::.| |.|.                    ||.|.:.::|...|
Mouse   339 FEMSTQFGLSPPDLHWVLGD-SQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVAT 402

  Fly   119 ------------------DADVTYVTHDPFSKNFLLYDVYNKGRQLGGELN------ITADREIF 159
                              |...|.:|...:...||....:   |.|.|.:.      ::::...|
Mouse   403 ATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTF---RGLSGSIKVKGSTIVSSENNFF 464

  Fly   160 CNKTNCRVERYLSELYTR------------------SALQHRKSFTGLTMRATAVVTAL--PLNV 204
            .  .|.:.:.....::||                  .|.:|:..|.........|||.:  |. |
Mouse   465 I--WNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPF-V 526

  Fly   205 SIKEI------------FDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFK------------- 244
            ..:|:            .|.|.:...| ||:.    :.:.....|.:..|||
Mouse   527 FTREVDDEGLCPAGQLCLDPMTNDSSI-LDSL----FSSLHSSNDTVPIKFKKCCYGYCIDLLEQ 586

  Fly   245 -----------YIFRD----RWSDGNATGGMIGDLILDKADLAIAPFIYSFDRAL---FLQPITK 291
                       ||..|    .|.:|:.| |::|||:...|::|:..|..:..|:.   |..|.
Mouse   587 LAEDMNFDFDLYIVGDGKYGAWKNGHWT-GLVGDLLSGTANMAVTSFSINTARSQVIDFTSPF-- 648

  Fly   292 FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWK---- 352
            ||....|.:  ..|..:|.:.|  |:.|....:||...:       .|.:|.|.....:||
Mouse   649 FSTSLGILV--RTRDTAAPIGA--FMWPLHWTMWLGIFV-------ALHITAIFLTLYEWKSPFG 702

  Fly   353 --------------PSLLTSC-LLSFGAGCIQGAWLTPRSMGGRMAFFALMVTSYLMYNYYTSIV 402
                          .|.|..| .|.||.   ..|...|:...||.......:......:.||:.:
Mouse   703 MTPKGRNRNKVFSFSSALNVCYALLFGR---TAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANL 764

  Fly   403 VSKLLGQPIKSNIRTLQQLADSNLDVGIEPTVYTRIYVETSEE------PDVRDLYRK------- 454
            .:.::|:.|   ...|..:.|..|....:...:..:...::|:      |::.:..|:
Mouse   765 AAVMVGEKI---YEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATP 826

  Fly   455 -KVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQI-----CELNEIPL 513
             .|...|..|:|:              :.|:           :.|..|.:::     |:|..:..
Mouse   827 DGVQYLKNDPEKL--------------DAFI-----------MDKALLDYEVSIDADCKLLTVGK 866

  Fly   514 RDASHTHTV-LAKRSP----YAELIKLSELRMLETGVHFK-------HERSWMETKLHCYQHNHT 566
            ..|...:.: |...||    .:|||...:.......:|.|       .:||:..|:        |
Mouse   867 PFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTE--------T 923

  Fly   567 VAVGLEYAAPLFIILLGAIILCMGILGLEVI 597
            :.:|:::.:.||      ::||:| .||.::
Mouse   924 LQMGIKHFSGLF------VLLCIG-FGLSIL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	66/352 (19%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	48/291 (16%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	45/293 (15%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	84/446 (19%)
		Lig_chan	676..942	CDD:278489	55/318 (17%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830