DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and Grin3a

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	134/757 - (17%)
Similarity:	246/757 - (32%)	Gaps:	258/757 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ILHC----SLSHLALLAQSKNIF------------TQFQPLHSDIQLNDDFLNHNILKLGVFLDI 71
            :|.|    :::...||.::.:.|            :..:.|.|.:|:..|.:.::...:.:|
  Rat   267 LLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMF--- 328

  Fly    72 NCDKSG--TVLDMASAKRFFSHRYHWLIYDRSMNF--------------------SVLESHFKEA 114
            .||...  .:.:|::.........||::.| |.|.                    ||.|.:.::|
  Rat   329 GCDMDSIRQIFEMSTQFGLSPPELHWVLGD-SQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDA 392

  Fly   115 QIFV------------------------DADVTYVTHDPFSKNFLLYDVYNKGRQLGGELN---- 151
            ...|                        |...|.:|...:...||....:   |.|.|.:.
  Rat   393 MELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTF---RGLSGSIKVKGS 454

  Fly   152 --ITADREIFCNKTNCRVERYLSELYTR------------------SALQHRKSFTGLTMRATAV 196
              |:::...|.  .|.:.:.....::||                  .|.:|:..|.........|
  Rat   455 TIISSENNFFI--WNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRV 517

  Fly   197 VTAL--PLNVSIKEIFD-------------FMNSKYRIQLDTYARLGYQARQPLRDMLDCKFK-- 244
            ||.:  |. |..:|:.|             ..|....:.     || :.:.....|.:..|||
  Rat   518 VTLIEHPF-VFTREVDDEGLCPAGQLCLDPMTNDSSMLD-----RL-FSSLHSSNDTVPIKFKKC 575

  Fly   245 ----------------------YIFRD----RWSDGNATGGMIGDLILDKADLAIAPFIYSFDRA 283
                                  ||..|    .|.:|:.| |::|||:...|::|:..|..:..|:
  Rat   576 CYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWT-GLVGDLLSGTANMAVTSFSINTARS 639

  Fly   284 L---FLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFIL 345
            .   |..|.  ||....|.:  ..|..:|.:.|  |:.|....:||...:       .|.:|.|.
  Rat   640 QVIDFTSPF--FSTSLGILV--RTRDTAAPIGA--FMWPLHWTMWLGIFV-------ALHITAIF 691

  Fly   346 ERRKQWK------------------PSLLTSC-LLSFGAGCIQGAWLTPRSMGGRMAFFALMVTS 391
            ....:||                  .|.|..| .|.||.   ..|...|:...||.......:..
  Rat   692 LTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGR---TAAIKPPKCWTGRFLMNLWAIFC 753

  Fly   392 YLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDVGIEPTVYTRIYVETSEE------PDVRD 450
            ....:.||:.:.:.::|:.|   ...|..:.|..|....:...:..:...::|:      |::.:
  Rat   754 MFCLSTYTANLAAVMVGEKI---YEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHE 815

  Fly   451 LYRK--------KVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQI-- 505
            ..|:        .|...|..|:|:              :.|:           :.|..|.:::
  Rat   816 YMRRYNVPATPDGVQYLKNDPEKL--------------DAFI-----------MDKALLDYEVSI 855

  Fly   506 ---CELNEIPLRDASHTHTV-LAKRSP----YAELIKLSELRMLETGVHFK-------HERSWME 555
               |:|..:....|...:.: |...||    .:|||...:.......:|.|       .:||:..
  Rat   856 DADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAV 920

  Fly   556 TKLHCYQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLEVI 597
            |:        |:.:|:::.:.||      ::||:| .||.::
  Rat   921 TE--------TLQMGIKHFSGLF------VLLCIG-FGLSIL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	66/352 (19%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	48/291 (16%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	36/238 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	34/210 (16%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	83/447 (19%)
		Lig_chan	676..942	CDD:278489	55/318 (17%)
		PPP2CB binding site	951..987
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349820
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830