DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and Grin3b

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	423	Identity:	84/423 - (19%)
Similarity:	153/423 - (36%)	Gaps:	153/423 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 DCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRAL---FLQPITKFSVFREICMF 301
            |.|:..:...||:      |::|||:..:|.:|:..|..:..|:.   |..|.  ||....| |.
  Rat   502 DGKYGALRDGRWT------GLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPF--FSTSLGI-MV 557

  Fly   302 RNPRSVSAGLSATEFLQPFSGGVWL-TFALLLLLAGCLLWVTFILERRKQWK-PSLLT------- 357
            |. |..::.:.|  |:.|....:|: .||.|.|.|   |::|..     :|: |..||
  Rat   558 RT-RDTASPIGA--FMWPLHWSMWVGVFAALHLTA---LFLTLY-----EWRSPYGLTPRGRNRG 611

  Fly   358 -----SCLLSFGAGCIQGAWL---TPRSMGGRM-----AFFALMVTSYLMYNYYTSIVVSKLLGQ 409
                 |..|:.....:.|..:   ||:...||.     |.|.|:|.|     .||:.:.:.::|.
  Rat   612 TVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLS-----SYTANLAAVMVGD 671

  Fly   410 PIKSNIRTLQQLA--------------------DSNLDVGIE---------------PTVYTRIY 439
                  :|.::|:                    :|:.:..|:               ||....:.
  Rat   672 ------KTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVA 730

  Fly   440 VETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGY----------- 493
            :.||:.|.:......|.|    ...::.|..:..:|:|  .:.|. |.|...|.
  Rat   731 MLTSDPPKLNAFIMDKSL----LDYEVSIDADCKLLTV--GKPFA-IEGYGIGLPQNSPLTSNLS 788

  Fly   494 EFVRKHFLAHQICELNEIPLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKL 558
            ||:.::                         |.|.:.:|:.....:|:..|     :|.:..|:
  Rat   789 EFISRY-------------------------KSSGFIDLLHDKWYKMVPCG-----KRVFAVTE- 822

  Fly   559 HCYQHNHTVAVGLEYAAPLFIILLGAIILCMGI 591
                   |:.:|:.:.:.||      ::||:|:
  Rat   823 -------TLQMGVYHFSGLF------VLLCLGL 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	72/370 (19%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	50/308 (16%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	73/368 (20%)
		Lig_chan	576..842	CDD:278489	60/335 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930