DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and gria2b

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	505	Identity:	118/505 - (23%)
Similarity:	200/505 - (39%)	Gaps:	102/505 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 QLGGELNITADREIFCNKTNCRVE-RYLSE----LYTRSALQHRKSFTGLTMRATAVVTALPL-N 203
            |.|..:|.|.:  :...|:|..|: .|.:|    :.|:|.|....:. ||..:...|.|.|.. .
Zfish   362 QYGKRVNYTVN--VMELKSNGAVKIGYWNEVDKMVVTKSDLFPNDTM-GLENKTVIVTTILEAPY 423

  Fly   204 VSIKEIFD-FM-NSKYRIQLDTYARLGYQARQPLRDMLDCKFKY---IFRD-----RWSDGNATG 258
            |.:|:..| || |.:|.         ||...........|.|||   |..|     |.::.....
Zfish   424 VMLKKNADLFMDNERYE---------GYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIWN 479

  Fly   259 GMIGDLILDKADLAIAPFIYSFDRAL---FLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPF 320
            ||:|:|:..|||:|:||...:..|..   |.:|.....:   ..|.:.|:....|:.:  ||.|.
Zfish   480 GMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGI---SIMIKKPQKSKPGVFS--FLDPL 539

  Fly   321 SGGVWLTFALLLLLAGCLLW-------VTFILERRK--QWKP-----------------SLLTSC 359
            :..:|:          |:::       |.|::.|..  :|..                 .:..|.
Zfish   540 AYEIWM----------CIVFAYIGVSVVLFLVSRFSPYEWHTEEYEDGQIQTNESTNEFGIFNSL 594

  Fly   360 LLSFGAGCIQGAWLTPRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLLGQPIKS--NIRT 417
            ..|.||...||..::|||:.||:.     ||.|::.|....|....:.|.::: .||:|  ::..
Zfish   595 WFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLAK 658

  Fly   418 LQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEA-GVLSVRDQE 481
            ..::|...||.|.....:.|..:.         |:.|.....|.:...:::.|.| ||:.||..:
Zfish   659 QTEIAYGTLDSGSTKEFFRRSKIA---------LFDKMWTYMKGAEPSVFVKTTAEGVMRVRKSK 714

  Fly   482 G-FVYITGVATGYEFVRKHFLAHQICELNEIPLR-DASHTHTVLAKRSPYAELIKLSELRMLETG 544
            | :.|:. .:|..|::.:    .:.|:..::... |:........|.|.....:.|:.|::.|.|
Zfish   715 GKYAYLL-ESTMNEYIEQ----RKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQG 774

  Fly   545 VHFKHERSWMETKLHC-----YQHNHTVAVGLEYAAPLFIILLGAIILCM 589
            :..|.:..|...|..|     .....|.|:.|...|.:|.||:|.:.|.|
Zfish   775 LLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAM 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	72/338 (21%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	61/275 (22%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	9/34 (26%)
		ANF_receptor	55..377	CDD:279440	4/16 (25%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	93/418 (22%)
		Lig_chan	542..820	CDD:278489	64/302 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740