DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and Grik5

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	688	Identity:	153/688 - (22%)
Similarity:	268/688 - (38%)	Gaps:	151/688 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KLSHVLI-LHCSLSHLALLAQSKNI-----FTQFQPL-------HSDIQLNDDFLNHNILKLGVF 68
            |:|.::| .:.|:||| :|..|.|:     |.:..||       .|::.:...|..: ||....|
Mouse   210 KVSTIIIDANASISHL-VLRLSLNLSSPLGFPRSLPLGLSCVLQASELGMTSAFYKY-ILTTMDF 272

  Fly    69 LDINCDKSGTVLDMASAKRF----FSHRYHWLIYDRSMNFSVLESHFKEAQIFVDADVTYVTHDP 129
            ..::.|  |.|.|.::...|    .||.: :..:.||:|.|..|:  .||.       ||  ..|
Mouse   273 PILHLD--GIVEDSSNILGFSMFNTSHPF-YPEFVRSLNMSWREN--CEAS-------TY--PGP 323

  Fly   130 FSKNFLLYDVYNKGRQLGGELNITAD---REIFCNKTNC---------------------RVE-- 168
            .....|::|..:.......|||.:.:   :.:.|...|.                     |||
Mouse   324 ALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFN 388

  Fly   169 ------RYLSELYTRSALQHRKSFTGLTMRATAV-VTALPLNVS------IKEIFDFMNSKYRIQ 220
                  .|...:..:|...||:.....:.|..|: .|.|.:|:|      ...:...:.:.|.::
Mouse   389 SKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMR 453

  Fly   221 LDTYARLGYQAR------QPLRDMLD-CKFKYIFR-------------DRWSDGNATGGMIGDLI 265
            ...:..|....|      ..||::.: .:|:|..|             ..|:      ||:|:||
Mouse   454 RPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWT------GMVGELI 512

  Fly   266 -LDKADLAIAPFIYSFDRAL---FLQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGV 324
             ..|||||:|.|..:.:|..   |.:|...  .|:...:.|.|.|...|       ||.|||..|
Mouse   513 NRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS-------FLDPFSPAV 570

  Fly   325 WLTFALLLLLAGCLLWVTFILERRKQWKP---------------SLLTSCLLSFGAGCIQGAWLT 374
            ||...|..|...|:|::...|...:.:.|               :|..|.....|....||:.:.
Mouse   571 WLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM 635

  Fly   375 PRSMGGR------MAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLAD-SNLDVGIEP 432
            ||::..|      .||..::::|      ||:.:.:.|..|.::..:.:...||| :|::.|...
Mouse   636 PRALSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIH 694

  Fly   433 TVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVR 497
            ...|..:.:.|.....:.::  ..:.||: |......||.|:..|.:.. :.::. .:|..|:.|
Mouse   695 AGSTMTFFQNSRYQTYQRMW--NYMQSKQ-PSVFVKSTEEGIARVLNSR-YAFLL-ESTMNEYHR 754

  Fly   498 KHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCY 561
            :     ..|.|.:| .|.|.......:...||:.:.|.|:.|::.|.......:|.|.|......
Mouse   755 R-----LNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPK 814

  Fly   562 QHNHTV-AVGLEYAAPLFIILLGAIILCMGILGLEVIW 598
            :.:|.. .:|:|....:|::|:..:|:.:.:..:|.||
Mouse   815 EEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIW 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	78/328 (24%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	53/265 (20%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	51/229 (22%)
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	88/399 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740