DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75b and Grid2

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	723	Identity:	142/723 - (19%)
Similarity:	247/723 - (34%)	Gaps:	229/723 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SKNIFTQFQPLHSDIQLN--DDFLNHNILKLGVFLDINCDKSGTVLDMASAKRFFSH-------- 91
            :|.|.|.|..:..: :||  .|.|...||               |::.|:||.|.|.
Mouse   205 NKMITTLFDTMRIE-ELNRYRDTLRRAIL---------------VMNPATAKSFISEVVETNLVA 253

  Fly    92 -RYHWLIYDRSMNFSVLESHFKEAQIFVDADVTYVTH---------------------------- 127
             ..||:|.:..:|               |.||..:..
Mouse   254 FDCHWIIINEEIN---------------DVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNH 303

  Fly   128 ----------DPFSKN------------FLLYDVYNK-------------------------GRQ 145
                      |||::|            .||.:.::|                         ||.
Mouse   304 RISSSLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRS 368

  Fly   146 L------GGELNITADREIFCNKTNCRVE------RYLSEL-------------------YTRSA 179
            :      ||...:|.|.|...|..|..|.      .|..||                   .|...
Mouse   369 MLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKK 433

  Fly   180 LQHRKSFTGLTMRATAVVTAL--PL-----NVSIK---------EIFDFMNSKYRIQLDTYARLG 228
            |::  :..|:.:|   |||.|  |.     ||..|         ::.|.:::......:.|....
Mouse   434 LEN--NMRGVVLR---VVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPD 493

  Fly   229 YQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFS 293
            ::...|..|           ..|:      |::|:|:..:||:.|:....:.||...:...|::.
Mouse   494 HKYGSPQED-----------GTWN------GLVGELVFKRADIGISALTITPDRENVVDFTTRYM 541

  Fly   294 VFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKPSLLTS 358
            .:....:.|.....   :.....|.||...:|...|..:||.|.|:::...|...:....|:.::
Mouse   542 DYSVGVLLRRAEKT---VDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTST 603

  Fly   359 CLLS-----FGAGCIQG-----AWLTPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKS 413
            .|.:     :|:...||     ..|..|.|.|....|||:|.|     .||:.:.:.|....|:|
Mouse   604 TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVIS-----SYTANLAAFLTITRIES 663

  Fly   414 NIRTLQQLA-DSNLDVG--IEPTVYTRIYVETSEEPDVRD-LYRK--KVLGSKRSPDKIWIPTEA 472
            :|::||.|: .:::..|  ::..||..:.:: ...|..|| :|.:  :::......:...:.::|
Mouse   664 SIQSLQDLSKQTDIPYGTVLDSAVYQHVRMK-GLNPFERDSMYSQMWRMINRSNGSENNVLESQA 727

  Fly   473 GVLSVR-DQEGFVYITGVATGYEFVRKHFLAHQICELNEIPLRDASHTHTV-LAKRSPYAELIKL 535
            |:..|: ....||:...|   .|:|.   :....|....:....|...:.: |...|||.::...
Mouse   728 GIQKVKYGNYAFVWDAAV---LEYVA---INDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQ 786

  Fly   536 SELRMLETGVH--FKHERSWMETKLHCYQHNHT------VAVGLEYAAPLFIILLGAIILCMGIL 592
            ..|.:.::|..  .||:  |......|..::..      .|:.::..|.:|.||...|:|...|.
Mouse   787 RILELQQSGDMDILKHK--WWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIA 849

  Fly   593 GLEVIWHR 600
            .||..|.|
Mouse   850 VLETWWSR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	68/319 (21%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	56/267 (21%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		30/170 (18%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	43/254 (17%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	84/402 (21%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740