Protein Alignment Ir75b and Gria2

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 512
• Identity: 120/512 - (23%)
• Similarity: 196/512 - (38%)
• Gaps: 102/512 - (19%)

  Fly   145 QLGGELNITADREIFCNKTN-CRVERYLSE----LYTRSALQHRKSFTGLTMRATAVVTAL--PL 202
            |.|..:|.|.:  |...||| .|...|.||    :.|.:.|......:||..:...|.|.|  |.
Mouse   364 QNGKRINYTIN--IMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPY 426

  Fly   203 NVSIKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKY---IFRD-----RWSDGNATGG 259
             |.:|:..:.:....|.:       ||...........|.|||   |..|     |.:|.....|
Mouse   427 -VMMKKNHEMLEGNERYE-------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNG 483

  Fly   260 MIGDLILDKADLAIAPFIYSFDRAL---FLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFS 321
            |:|:|:..|||:||||...:..|..   |.:|.....:   ..|.:.|:....|:.:  ||.|.:
Mouse   484 MVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI---SIMIKKPQKSKPGVFS--FLDPLA 543

  Fly   322 GGVWLTFALLLLLAGCLL----------WVTFILERRKQWKPS-------LLTSCLLSFGAGCIQ 369
            ..:|:......:....:|          |.|...|..::.:.|       :..|...|.||...|
Mouse   544 YEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQ 608

  Fly   370 GAWLTPRSMGGRMA-----FFALMVTSYLMYNYYTSIVVSKLLGQPIKS--NIRTLQQLADSNLD 427
            |..::|||:.||:.     ||.|::.|....|....:.|.::: .||:|  ::....::|...||
Mouse   609 GCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV-SPIESAEDLSKQTEIAYGTLD 672

  Fly   428 VGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWI------------PTEAGVLSVRDQ 480
            .|                 ..::.:|:..:...   ||:|.            .|..||..||..
Mouse   673 SG-----------------STKEFFRRSKIAVF---DKMWTYMRSAEPSVFVRTTAEGVARVRKS 717

  Fly   481 EG-FVYITGVATGYEFVRKHFLAHQICELNEIPLR-DASHTHTVLAKRSPYAELIKLSELRMLET 543
            :| :.|:. .:|..|::.:    .:.|:..::... |:........|.|.....:.|:.|::.|.
Mouse   718 KGKYAYLL-ESTMNEYIEQ----RKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQ 777

  Fly   544 GVHFKHERSWMETKLHC-----YQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLE 595
            ||..|.:..|...|..|     .....|.|:.|...|.:|.||:|.:.|.|.:..:|
Mouse   778 GVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	19/55 (35%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	20/68 (29%)
		Lig_chan	343..584	CDD:459656	59/273 (22%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	12/35 (34%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	92/419 (22%)