DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir75b and GRIN3A

DIOPT Version :9

Sequence 1:NP_001137966.2 Gene:Ir75b / 8673994 FlyBaseID:FBgn0261402 Length:605 Species:Drosophila melanogaster
Sequence 2:NP_597702.2 Gene:GRIN3A / 116443 HGNCID:16767 Length:1115 Species:Homo sapiens


Alignment Length:821 Identity:146/821 - (17%)
Similarity:258/821 - (31%) Gaps:307/821 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LQLHNLILH----------------NLIHMAKLSHVLILHCSLSHLALLAQS---KNIFTQFQPL 47
            |.|.:|:||                |.:|:.     |.|..|||..|.:..|   .|.:..|..|
Human   209 LDLVSLVLHIPVISIVRHEFPRESQNPLHLQ-----LSLENSLSSDADVTVSILTMNNWYNFSLL 268

  Fly    48 --HSDIQLNDDFL---NHNILKLGVFLDINC--------------------DKSGTVL----DMA 83
              ..|..:.|..|   |::...||..::|..                    :.:.||:    ||.
Human   269 LCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDME 333

  Fly    84 SAKRFFS---------HRYHWLIYDRSMNF--------------------SVLESHFKEAQIFV- 118
            |.:|.|.         ....|::.| |.|.                    ||.|.:.::|...| 
Human   334 SIRRIFEITTQFGVMPPELRWVLGD-SQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVA 397

  Fly   119 -----------------------DADVTYVTHDPFSKNFLLYDVYNKGRQLGGELN------ITA 154
                                   :.:.|.:|...:...||....:   |.|.|.:.      :::
Human   398 RAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTF---RGLSGSIRVKGSTIVSS 459

  Fly   155 DREIFCNKTNCRVERYLSELYTR------------------SALQHRKSFTGLTMRATAVVTAL- 200
            :...|.  .|.:.:.....::||                  .|.:|:..|...:.....|||.: 
Human   460 ENNFFI--WNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIE 522

  Fly   201 -PLNVSIKEIFDFMNSKYRIQLDTYARLGYQARQPL-----------------RDMLDCKFK--- 244
             |. |..:|:.|          :.....|.....|:                 .|.:..|||   
Human   523 HPF-VFTREVDD----------EGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCC 576

  Fly   245 ---------------------YIFRD----RWSDGNATGGMIGDLILDKADLAIAPFIYSFDRAL 284
                                 ||..|    .|.:|:.| |::|||:...|.:|:..|..:..|:.
Human   577 YGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWT-GLVGDLLRGTAHMAVTSFSINTARSQ 640

  Fly   285 ---FLQPITKFSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILE 346
               |..|.  ||....|.:  ..|..:|.:.|  |:.|....:||...:       .|.:|.:..
Human   641 VIDFTSPF--FSTSLGILV--RTRDTAAPIGA--FMWPLHWTMWLGIFV-------ALHITAVFL 692

  Fly   347 RRKQWK------------------PSLLTSC-LLSFGAGCIQGAWLTPRSMGGRMAFFALMVTSY 392
            ...:||                  .|.|..| .|.||...   |...|:...||.......:...
Human   693 TLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTV---AIKPPKCWTGRFLMNLWAIFCM 754

  Fly   393 LMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDVGIEPTVYTRIYVETSEE------PDVRDL 451
            ...:.||:.:.:.::|:.|   ...|..:.|..|....:...:..:...::|:      |::.:.
Human   755 FCLSTYTANLAAVMVGEKI---YEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEY 816

  Fly   452 YRKKVLGS--------KRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQI--- 505
            .|:..:.:        |..|:|:              :.|:           :.|..|.:::   
Human   817 MRRYNVPATPDGVEYLKNDPEKL--------------DAFI-----------MDKALLDYEVSID 856

  Fly   506 --CELNEIPLRDASHTHTV-LAKRSP----YAELIKLSELRMLETGVHFK-------HERSWMET 556
              |:|..:....|...:.: |...||    .:|||...:.......:|.|       .:||:..|
Human   857 ADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVT 921

  Fly   557 KLHCYQHNHTVAVGLEYAAPLFIILLGAIILCMGILGLEVI 597
            :        |:.:|:::.:.||      ::||:| .||.::
Human   922 E--------TLQMGIKHFSGLF------VLLCIG-FGLSIL 947

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir75bNP_001137966.2 Periplasmic_Binding_Protein_Type_2 253..553 CDD:304360 64/352 (18%)
Lig_chan 343..585 CDD:278489 46/291 (16%)
GRIN3ANP_597702.2 PBP1_iGluR_NMDA_NR3 30..497 CDD:107372 51/298 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..118
ANF_receptor 127..469 CDD:279440 49/270 (18%)
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 80/451 (18%)
Lig_chan 676..942 CDD:278489 53/318 (17%)
PPP2CB binding site. /evidence=ECO:0000250 951..987
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1062..1095
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155907
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.830

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