Protein Alignment Ir75b and grik5

DIOPT Version :10

• Sequence 1: NP_001137966.2
• Gene: Ir75b / 8673994
• FlyBaseID: FBgn0261402
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: XP_002936446.1
• Gene: grik5 / 100497490
• XenbaseID: XB-GENE-953974
• Length: 995
• Species: Xenopus tropicalis
• Alignment Length: 732
• Identity: 149/732 - (20%)
• Similarity: 265/732 - (36%)
• Gaps: 208/732 - (28%)

  Fly     1 MLQLHNLILHNLIHMAKLSHVLILHCSLSHLALLAQSKNIFTQFQPLHSDIQLNDDFLNHNILKL 65
            :|:|..|:...||....||           :.:|.:|.:.    .||..:|:  ||.::
 Frog   175 LLRLEELVRQFLISKDTLS-----------VRMLDESNDP----TPLLKEIR--DDKVS------ 216

  Fly    66 GVFLDINCDKSGTVLDMASAKRFFSHRYHWLIYDRSMNFSVLESHFKEAQIFVDADVTYVTHDPF 130
            .:.:|.|...|..:|..||.....|..|.:::  .:|:|.:|             .:..:..|
 Frog   217 TIIIDANATVSHLILKKASELGMTSAHYKYIL--TTMDFPLL-------------SLEGIVSD-- 264

  Fly   131 SKNFLLYDVYNKGRQLGGE----LNITADREIFCNKTNCRVERYLSELYTRSAL----------- 180
            ..|.|.:.:||.......|    ||::.       :.||.:..||....:.:.:
 Frog   265 QSNILGFSMYNSSHPFYLEFLRSLNMSW-------RENCELSTYLGPALSAALMFDAVHVVVSAV 322

  Fly   181 ----------------------QHRKS---------FTGLTMRA--------------------- 193
                                  ||..|         :.|||.|.
 Frog   323 RELNRSQEIGVKQLSCSTSQIWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKAGD 387

  Fly   194 ------------TAVVTALPLNVSIKEIFD--------FMNSKYRIQLDTYARL-------GYQA 231
                        |..:.|..|::|..|..:        .:.:.|.::...|..|       |:.|
 Frog   388 GHREIGVWYSNRTLAMNATSLDLSTSETLENKTLVVTTILENPYMMRKSNYRSLSGNDQYEGFCA 452

  Fly   232 RQPLRDMLDCKFKY--------IFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRAL---F 285
            ...:......:|.|        ::.....:|:.| ||:|:||..|||||:|.|..:.:|..   |
 Frog   453 EMLMELAALLRFNYKIKLVEDGLYGAPEPNGSWT-GMVGELINRKADLAVAAFTITAEREKVIDF 516

  Fly   286 LQPITK--FSVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERR 348
            .:|...  .|:...:.|.|.|...|       ||.|||..|||...|..|...|:|::...|...
 Frog   517 SKPFMTLGISILYRVQMGRKPGYFS-------FLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPY 574

  Fly   349 KQWKP---------------SLLTSCLLSFGAGCIQGAWLTPRSMGGR------MAFFALMVTSY 392
            :.:.|               :|..|.....|....||:.:.||::..|      .||..::::|
 Frog   575 EWYNPHPCLRERHHILENQYTLGNSLWFPVGGFMQQGSEVMPRALSTRCVSGVWWAFTLIIISS- 638

  Fly   393 LMYNYYTSIVVSKLLGQPIKSNIRTLQQLAD-SNLDVGIEPTVY---TRIYVETSEEPDVRDLYR 453
                 ||:.:.:.|..|.::..|.:...||| :|::.|   |::   |..:.:.|.....:.::
 Frog   639 -----YTANLAAFLTVQRMEVPIESADDLADQTNIEYG---TIHGGSTMTFFQNSRYQTYQRMW- 694

  Fly   454 KKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEI-PLRDAS 517
             ..:.||: |......||.|:..|.:.. :.::. .:|..|:.|:     ..|.|.:| .|.|..
 Frog   695 -NYMNSKQ-PSVFVKSTEEGIARVLNSR-YAFLL-ESTMNEYHRR-----LNCNLTQIGGLLDTK 750

  Fly   518 HTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV-AVGLEYAAPLFIIL 581
            .....:...|||.:.|.|:.|::.|.......:|.|.|......:.:|.. .:|:|....:|::|
 Frog   751 GYGIGMPLGSPYRDEITLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVL 815

  Fly   582 LGAIILCMGILGLEVIW 598
            :..:|:.:.:..:|.:|
 Frog   816 ICGLIIAVFVAIMEFVW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Lig_chan-Glu_bd	<235..283	CDD:463166	16/55 (29%)
		Periplasmic_Binding_Protein_Type_2	<259..>325	CDD:473866	25/70 (36%)
		Lig_chan	343..584	CDD:459656	56/267 (21%)
grik5	XP_002936446.1	PBP1_iGluR_Kainate_KA1_2	27..405	CDD:380616	45/276 (16%)
		Periplasmic_Binding_Protein_Type_2	418..788	CDD:473866	91/396 (23%)