DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and grik4

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_031761990.1	Gene:	grik4 / 100490768	XenbaseID:	XB-GENE-1011875	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	712	Identity:	151/712 - (21%)
Similarity:	261/712 - (36%)	Gaps:	188/712 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CSLSHLALLAQ---SKNIFTQFQPLHSDIQLNDDFLNHN-ILKLGVFLDINCDKSGTVLDMASAK 86
            |.|:...||.|   ||:..:        :::.||..:.. :||     :|..||:.|::..|:|.
Frog   170 CLLNLEKLLRQFLISKDCLS--------VRMLDDTWDPTPLLK-----EIRDDKTSTIIVHANAS 221

  Fly    87 --------------------------RFFSHRYHWLIYDR------SMNFSVLESHFKE-AQIFV 118
                                      .|...|:...:.||      || |:...|:||| |....
Frog   222 MSHTILMKAAELGMVTAYYTYIFTNLEFVLQRFESPLDDRVNILGFSM-FNQSHSYFKEFAHTLQ 285

  Fly   119 DADVTYVTHDPFS----KNFLLYD-VY---------NKGRQLGGELNITADREIFCNKTNCRVER 169
            .:......|.||:    ...||:| ||         |:.:::|.:.......:|:.:.|:.....
Frog   286 QSWEENCDHSPFTGPALSAALLFDAVYGIVSAVQELNRSQEIGVKPLSCGSSQIWQHGTSLMNYL 350

  Fly   170 YLSEL-----------------YTRSALQHRKS----------FTGLTM--------------RA 193
            .:.||                 |....:|:.|:          ..||.|              ..
Frog   351 RMVELEGLTGHVEFNSKGQRSNYDMKIMQYTKTGFQEIGQWHVTNGLNMDKRYFSPNASDTLVNK 415

  Fly   194 TAVVTALPLNVSIKEIFDFMNSKYRIQLDTYARLGYQARQP--LRDMLD-----CKFKYIFRDRW 251
            |.:||.:        :|....:.|.:....:..|....|..  ..|||.     .:|.|..| ..
Frog   416 TLIVTTI--------LFFLQENPYLMLKANHQELEGNDRYEGFCVDMLKELAAILRFNYKIR-LV 471

  Fly   252 SDG-------NAT-GGMIGDLILDKADLAIAPFIYSFDRAL---FLQPITK--FSVFREICMFRN 303
            :||       |.| .||:|:||..|||||:|....:.:|..   |.:|...  .|:...:.|.|.
Frog   472 ADGVYGVPELNGTWTGMVGELISRKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRK 536

  Fly   304 PRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP--------------- 353
            |...|       ||.|||.||||...|..|...|:|::...|...:.:.|
Frog   537 PGYFS-------FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQY 594

  Fly   354 SLLTSCLLSFGAGCIQGAWLTPRSMGGR------MAFFALMVTSYLMYNYYTSIVVSKLLGQPIK 412
            ||..|.....|....||:.:.||::..|      .||..::::|      ||:.:.:.|..|.:.
Frog   595 SLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISS------YTANLAAFLTVQRMD 653

  Fly   413 SNIRTLQQLAD-SNLDVGIEPTVY---TRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAG 473
            ..|.::..||| :.::.|   |::   :..:.:.|.....:.::  ..:.||: |......||.|
Frog   654 VPIESVDDLADQTTIEYG---TIHGGSSMTFFQNSRYQTYQRMW--NYMHSKQ-PSVFVKSTEEG 712

  Fly   474 VLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAELIKLSE 537
            :..|.: ..:.::      .|.....:...:.|.|.:: .|.|.......:...|.:.:...|:.
Frog   713 IARVLN-SNYAFL------LESTMNEYYRQRNCNLTQVGGLLDTKGYGIGMPVGSAFRDEFDLAI 770

  Fly   538 LRMLETGVHFKHERSWMETKLHCYQHNHTV-AVGLEYAAPLFIILLGAIILCMGILGLEVIW 598
            |::.|.......:|.|.:......:.:|.. .:|:|....:|::|:..:|:.:.|..||.:|
Frog   771 LQLQENNCLEDLKRKWWDGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAILIAMLEFLW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	78/338 (23%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	48/268 (18%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:415822	48/243 (20%)
grik4	XP_031761990.1	PBP2_iGluR_kainate_KA1	414..788	CDD:270442	92/408 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910