DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and grin2b

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_017948700.2	Gene:	grin2b / 100490580	XenbaseID:	XB-GENE-949327	Length:	1449	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	84/395 - (21%)
Similarity:	153/395 - (38%)	Gaps:	83/395 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 NAT-GGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFSV-FRE----ICMFRNPRSVSAGLSA 313
            |.| .||||:::..:|.:|:.....:.:|:    .:..||| |.|    :.:.|:..:|    |.
Frog   488 NGTWNGMIGEVVTKRAYMAVGSLTINEERS----EVVDFSVPFIETGISVMVSRSNGTV----SP 544

  Fly   314 TEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKPSLLTSCLL--------SFGAGCIQG 370
            :.||:|||..||:...::||:...:  ..|:.|   .:.|.....||.        ||..|  :.
Frog   545 SAFLEPFSADVWVMMFVMLLIVSAV--AVFVFE---YFSPVGYNRCLADGREPGGPSFTIG--KA 602

  Fly   371 AWL------------------TPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRT 417
            .||                  |.:.|....||||::..:....|....::..:.:.|....:.:.
Frog   603 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKK 667

  Fly   418 LQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRK----KVLGSKRSPDKIWIPTEAGVLSVR 478
            .|:..|      ..|..........|.|.::|:.|.:    .|..::||.....:..:.|.|
Frog   668 FQRPND------FSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQRSVQDALLSLKTGKL--- 723

  Fly   479 DQEGFVYITGVATGYEFVRKHFLA--HQICELNEIPLRDASHT---HTVLAKRSPYAELIKLSEL 538
              :.|:|...|.        :::|  .:.|:|..|.......|   ...:.|.|.:...:.|:.|
Frog   724 --DAFIYDAAVL--------NYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAIL 778

  Fly   539 RMLETGVHFKHERSWMETKLHCYQHNHTV---AVGLEYAAPLFIILLGAIILCMGILGLE--VIW 598
            ::...|...:.|..|: |.: |:...:.|   .:.::..|.:|.:|..|:.|.:....:|  ..|
Frog   779 QLFGDGEMEELEALWL-TGI-CHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFFW 841

  Fly   599 H-RHC 602
            . |||
Frog   842 QLRHC 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	70/338 (21%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	51/279 (18%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	73/347 (21%)
		NMDAR2_C	837..1449	CDD:402274	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910