DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75b and LOC100331381

DIOPT Version :9

Sequence 1:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster
Sequence 2:	XP_017207884.1	Gene:	LOC100331381 / 100331381	-ID:	-	Length:	1063	Species:	Danio rerio

Alignment Length:	741	Identity:	158/741 - (21%)
Similarity:	270/741 - (36%)	Gaps:	200/741 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLQLHNLILHNLIHMAKLSHVLILHCSLSHLALLAQSKNIFTQFQPLHSDIQLNDDFLNHNILKL 65
            :|:|..|:.|.||....|| |.:|..:|....||.                ::.||       |:
Zfish   183 LLRLEELVRHFLISRETLS-VRMLDENLDPTPLLK----------------EIRDD-------KV 223

  Fly    66 G-VFLDINCDKSGTVLDMASAKRFFSHRYHWLIYDRSMNFSV--LESHFKEAQIFVDADVTYVTH 127
            . :.:|.|...|..:|..||.....|..|.:::  .:|:|.:  |:....:....|...:...:|
Zfish   224 ATIIIDANASVSILILKKASELGMTSAFYKYIL--TTMDFPLLRLDDVVNDQSNIVGFSMLNNSH 286

  Fly   128 DPFSKNF-------------------------LLYDV----------YNKGRQLGGE-LNITAD- 155
             ||...|                         |::|.          .|:.:::|.: |:.|:.
Zfish   287 -PFYLEFIRSLNLSWREGCDLSPYPGPALSSALMFDAVHVVVGAVRELNRSQEIGVKPLSCTSSL 350

  Fly   156 ------------REIFCNKTNCRVERYLSELYTRSALQHRKSFTG-------------LTMRATA 195
                        |.:..:....|||.......|...|:..:.|.|             |.|.:|:
Zfish   351 IWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKFKGGHKEIGVWYSNNTLAMNSTS 415

  Fly   196 V--------------VTALPLN--VSIKEIF-DFMNSKYRIQLDTYARLGYQARQPLRDMLDCKF 243
            :              ||.:..|  |..||.: ||..|      |.|........:.|.|:|
Zfish   416 LDINTSETLANKTLTVTTILENPYVMRKENYQDFQGS------DQYEGFCVDMLRELADIL---- 470

  Fly   244 KYIFRDRWSDGNATG---------GMIGDLILDKADLAIAPFIYSFDRAL---FLQPITK--FSV 294
            |:.||.:..|....|         ||:|:||..|||||:|.|..:.:|..   |.:|...  .|:
Zfish   471 KFSFRIKLVDDGLYGAPEPNGSWTGMVGELINRKADLAVAGFTITSEREKVIDFSKPFMNLGISI 535

  Fly   295 FREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP------ 353
            ...:.:.|.|...|       ||.|||..|||...|..|...|:|::...|...:.:.|
Zfish   536 LYRVHIGRKPGYFS-------FLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPFPCWRE 593

  Fly   354 ---------SLLTSCLLSFGAGCIQGAWLTPRSMGGR------MAFFALMVTSYLMYNYYTSIVV 403
                     :|..|.....|....||:.:.||::..|      .||..::::|      ||:.:.
Zfish   594 RRDLLENQYTLGNSLWFPIGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISS------YTANLA 652

  Fly   404 SKLLGQPIKSNIRTLQQLAD-SNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIW 467
            :.|..|.::..|.:.:.||| :|:..|......|..:...|.....:.::  ..:.||: |....
Zfish   653 AFLTVQRMEVPIESAEDLADQTNIQYGTIQGGSTMTFFMNSRYQTYQRMW--NYMYSKQ-PSVFV 714

  Fly   468 IPTEAGVLSVRDQEGFVYITGVATGYEFVRKHFLAHQICELNEI-PLRDASHTHTVLAKRSPYAE 531
            ..||.|:..|.:.: :.::. .:|..|:.|:     ..|.|.:| .|.|.......:...||:.:
Zfish   715 KSTEEGIARVLNSK-YAFLL-ESTMNEYHRR-----LNCNLTQIGGLLDTKGYGIGMPLGSPFRD 772

  Fly   532 LIKLSELRMLETGVHFKHERSWMETKLHCYQHNHTV-AVGLEYAAPLFIILLGAIILCMGILGLE 595
            .|.|..|::.|.......:|.|.|......:.:|.. .:|::....:|::|:..:|:.:.:..:|
Zfish   773 EITLGILQLQENNRLEILKRRWWEGGKCLKEEDHRAKGLGMDNIGGIFVVLICGLIIAVFVAIME 837

  Fly   596 VIW--------------------HRH 601
            .:|                    |||
Zfish   838 FVWSTRRSAETDEVRPHPCPVRNHRH 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	80/336 (24%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	53/265 (20%)
LOC100331381	XP_017207884.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910