DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nost and POSH

DIOPT Version :9

Sequence 1:	NP_001285029.1	Gene:	Nost / 8673992	FlyBaseID:	FBgn0259734	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_523776.1	Gene:	POSH / 36990	FlyBaseID:	FBgn0040294	Length:	838	Species:	Drosophila melanogaster

Alignment Length:	1038	Identity:	209/1038 - (20%)
Similarity:	334/1038 - (32%)	Gaps:	338/1038 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 VALDMNVTAP-AKLGLDLNLPELPE-------LYGASELSLAASDNKENLPAVKPSAERSPIPNG 446
            ||....:..| .::.:...:.|||.       |.|..: :.||...:|.....:...||:
  Fly    41 VASQHKLRCPECRILVSCKIDELPPNVLLMRILEGMKQ-NAAAGKGEEKGEETETQPERA----- 99

  Fly   447 GFMAQQPHFKSL---DSFHLNTRSH--SNQSSQQSSRQSLACSSSNGEYDF-------------D 493
               ..||..:|:   |:..|..:||  |:|.::...|:.| ...:...:||             |
  Fly   100 ---KPQPPAESVAPPDNQLLQLQSHQQSHQPARHKQRRFL-LPHAYALFDFASGEATDLKFKKGD 160

  Fly   494 LKSVSYQSLNAQNLFVSIDELQELTRQINETEDFGKEIDLEYC-AHRD-QLRPSERRITLLKNKN 556
            |..:.::..|  |.||.....||.|..||..: ....:.:..| |..| ::.|::.. ..|:.|.
  Fly   161 LILIKHRIDN--NWFVGQANGQEGTFPINYVK-VSVPLPMPQCIAMYDFKMGPNDEE-GCLEFKK 221

  Fly   557 QTLINFNHNKEKLRKGWHGMKHWL-GEEGSKIK----EAVRQQTPLKRLAQSRSNLNQSTADASR 616
            .|:|      :.:|:..|   :|. |..|..|.    ..|......|:|..|..:.:.......:
  Fly   222 STVI------QVMRRVDH---NWAEGRIGQTIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQ 277

  Fly   617 QSMS-----PERTQRDVTESCEDVTERTEMESSMSHRNSEEDLSPH------------------A 658
            |...     |......||||....:..|...|:.|..:|..:.||:                  :
  Fly   278 QGQRALPPVPVIDPTVVTESSSGSSNSTPGSSNSSSTSSSNNCSPNHQISLPNTPQHVVASGSAS 342

  Fly   659 KRFKDEGQNGFEELRRYVKQ--GGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREIPGS 721
            .||:|:|.   :|.|..:..  ||  ...|..:...|..:|::      .|.::|::.  |:..|
  Fly   343 VRFRDKGA---KEKRHSLNALLGG--GAPLSLLQTNRHSAEIL------SLPHELSRL--EVSSS 394

  Fly   722 VADAWRGVATEMESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAARVLGEWRAS 786
            .|                            :||                ::..:.:|||
  Fly   395 TA----------------------------LKP----------------TSAPQTSRVL------ 409

  Fly   787 EAKAKKASHTAARENEKLQDAMLDVRIQKSPS-----IALLHQGPNKQAAEKELKSAEKDCVKLD 846
                                 ...|:.|..|:     :||....| :|..|.|||   |.||.:.
  Fly   410 ---------------------KTTVQQQMQPNLPWGYLALFPYKP-RQTDELELK---KGCVYIV 449

  Fly   847 NKR-----KKAEEAVKRADV---EYYT-LCVRSERARV-DWEMAVLRGSAQLQSSEQQ------R 895
            .:|     .|.:..:....|   .|.| |..|.::..: .|:.......||:...:|.      |
  Fly   450 TERCVDGWFKGKNWLDITGVFPGNYLTPLRARDQQQLMHQWKYVPQNADAQMAQVQQHPVAPDVR 514

  Fly   896 LGNMHNFAQQYARLISDMNPILGGLSTRLQPQLDACNV-AKDMQVVRHIRRNSEGPSEQLLPDFY 959
            |.||          :|...|.|.....:......:|:| :|.::.:  ..|.|| |.    |:..
  Fly   515 LNNM----------LSMQPPDLPPRQQQATATTTSCSVWSKPVEAL--FSRKSE-PK----PETA 562

  Fly   960 CEHTTLAMNRERRKHALIKLLQLVKTDLERERRSRDGLRGLSQSLNHQEHQNITDKLYHIRSMLT 1024
            ...||.:                          |..|..||.:.|.|.:.::        :|...
  Fly   563 TASTTSS--------------------------SSSGAVGLMRRLTHMKTRS--------KSPGA 593

  Fly  1025 YLEGARLKLHSALLELDHKPRA-THPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQT-QQSTS 1087
            .|:....:..|..:|....|.| .||    :|:   |:|...|.|:....|.....::| .|...
  Fly   594 SLQQVPKEAISTNVEFTTNPSAKLHP----VHV---RSGSCPSQLQHSQPLNETPAAKTAAQQQQ 651

  Fly  1088 MLAHDITDITTNHEDELPDENCSHLHSSSHSNNNSNGS-------CTDVSSVVKPFNRSKSNIET 1145
            .|...:...:||              |.|:.:....||       |...|.....| ||..|
  Fly   652 FLPKQLPSASTN--------------SVSYGSQRVKGSKERPHLICARQSLDAATF-RSMYN--- 698

  Fly  1146 NFTSQPKIISTTNAAIAVSVKSKTLANLQDGHHNNQQHHH------HHHNHHSDRGQADGGSNQQ 1204
            |..|.|.  .||:.|.||....:... :..|...:|.|.:      |..:|..|.......|:.
  Fly   699 NAASPPP--PTTSVAPAVYAGGQQQV-IPGGGAQSQLHANMIIAPSHRKSHSLDASHVLSPSSN- 759

  Fly  1205 DSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQNPTINGQVQTQHFYQNAQELQKGQKNG 1269
                                               ::....|.....|:..|...:
  Fly   760 -----------------------------------MITEAAIKASATTKSPYCTRE--------- 780

  Fly  1270 SVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDDGWWLGA-LRNH-IGIFPATYVE-EC 1329
                 .|.:.:..|.|....||||..||||.|..||.:||:.|. .|.| .|:|||::|| :|
  Fly   781 -----SRFRCIVPYPPNSDIELELHLGDIIYVQRKQKNGWYKGTHARTHKTGLFPASFVEPDC 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	48/267 (18%)
Nost	NP_001285029.1	SH3_Nostrin	1276..1328	CDD:212757	25/54 (46%)
POSH	NP_523776.1	RING	11..53	CDD:238093	3/11 (27%)
		SH3	139..191	CDD:302595	13/54 (24%)
		SH3_SH3RF_2	199..251	CDD:212721	14/61 (23%)
		SH3_SH3RF_3	424..477	CDD:212717	15/56 (27%)
		SH3_SH3RF_C	782..836	CDD:212719	24/53 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I3230
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR14167
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.100