DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nost and CAP

DIOPT Version :9

Sequence 1:	NP_001285029.1	Gene:	Nost / 8673992	FlyBaseID:	FBgn0259734	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster

Alignment Length:	1796	Identity:	304/1796 - (16%)
Similarity:	537/1796 - (29%)	Gaps:	688/1796 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LKSLRSSARYAKAKS---------------------KSAIN--------LNAH-----------L 43
            :|.|:.:|..:|:.|                     :..:|        |:||           |
  Fly   972 IKELQLNANESKSSSAWLGLPTQSDPKLLVCLSPGQRDLVNNQTQPDDLLDAHQKFVERRGYHEL 1036

  Fly    44 KKQQKLEEGHPEKKRQDKKI------LRQSVSEDQPIYANVDEVIPIHLEPETGTEVDALMGNAQ 102
            .|.|.||:.|.:::.:..|.      ||:|:|...|       .:|....|....|..|.....:
  Fly  1037 SKAQVLEQDHQQQQSEMLKTAAMMRELRKSLSPPAP-------PVPPPPVPVKSAETAAKATAHE 1094

  Fly   103 PSKMNHLRVHKFKLGGKDNAAMADLP---------------QSENTTNNNNNIGSNNNQKGGAK- 151
            .:|.:.....|.|:...:::::.:.|               ||.:||.:::...:.......||
  Fly  1095 NAKRDDASEQKQKIAACESSSLENKPRRAADLGAQQSAEQRQSSSTTTSSHKATTETMSSDTAKF 1159

  Fly   152 -------GFLGRI-------------KRYSVLGNKLGRRNLGSMNLNPPNNVVDNSVSPTK---- 192
                   ..|.|:             ||:|              |:..|::   ..||.||
  Fly  1160 PTLDSMESELARMFPQHKGDIFEEQRKRFS--------------NIEFPSH---QPVSQTKRYSN 1207

  Fly   193 LHTGSYN--------------MTGSH---------SDDHRLEIGAPILISTTTLDTDRFDVTEAR 234
            :.|.||.              .|.||         .|.....:..|.::|.|.|:.:.|
  Fly  1208 IETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGNTF------ 1266

  Fly   235 LKQIGGGIAQTSSIVRTLTPRSSDE---EEF---VDARSSPQQMERDEDLQIADDQVEKNDRDQY 293
               |.|.:|..:|.....:...|..   |||   ..|.:.....:|::...:..|:|.| |.|:.
  Fly  1267 ---IDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQNGLDQDRVFK-DFDRL 1327

  Fly   294 GHQF--QLPKKQHREEEMGDLKYLDDLEEPEQFETPKHEVEEKLLTANQDVKRPI---------- 346
            ..|.  :|...:.:.|:...:..|.....|........|::::.....|:::|.|
  Fly  1328 SQQMHAELQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQELEREIERSAKSRQER 1392

  Fly   347 ----------TP-----ITIAIDPPIRRPRIARQQRQSQSVQNLH----RSELKV--YLHK---- 386
                      ||     |.|.::|         :.|:::|:.||:    |....|  |.|.
  Fly  1393 MSSVPRQMEATPPRTHEIPIELEP---------RSRRAESLCNLNEPPPRPHTTVGHYNHPVVQD 1448

  Fly   387 -----SNSVALDMNVTAPAKLGLDL----NLPELPELYGASELSLAASD-------NKENLPAVK 435
                 :|.:....|:..|....:::    .....|....|..||.:.:|       :.:...|..
  Fly  1449 DWSRYANDLGYSENIARPFAREVEICYQRQNQRTPHCIRAPRLSASTNDLSSSSQYSYDTFNAYG 1513

  Fly   436 PSAERSPIPNGGFMAQQPHFKSLDSF--------HLNTRSHSNQS---------SQQS------S 477
            .....:|:.|.....|:||:.|..|.        :::|.|....|         .||.      .
  Fly  1514 GRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPVATPQQQQVPPPAYD 1578

  Fly   478 RQSLACSSSNGEYDFDLKSVSYQSLNAQNLFVSIDELQELTRQINETEDFGKEIDLEYCAHRDQL 542
            ||....|.....::..||   |.....:.|...::.||:..|::  .|:..:...|.....|:..
  Fly  1579 RQQRRSSLPRELHEQQLK---YILSKEEELKFEVERLQQERRRL--MEEMQRAPVLPAPQRRESY 1638

  Fly   543 RPSERRITLLKNKNQTLINFNHNKEKLRKGWHGMKHWLGEEGSKIKE-AVRQQTPLKRLAQSRSN 606
            ||:.:..||.::            |..|:  ...:.|:    :|:.| ..|:|..:.|:::....
  Fly  1639 RPAAKLPTLSED------------EVFRQ--QMAEEWM----NKVAEREERRQHKIIRISKIEDE 1685

  Fly   607 LNQSTADASRQSMSPERTQR----------DVTESCEDVTERTEMESSMSHRNSEEDLSPHAKRF 661
            .:.|..|  :.::|.|...|          ......|...|.....::.|...|:.: :|..:..
  Fly  1686 HDHSAVD--KATISDEFLDRVKERRHKLSMPADSDWESGAESQPQPAAQSQPESDVE-APPVRIL 1747

  Fly   662 KDEGQNGFEELRRYVKQGGDFS--------------KELIFVLQERAD--SELIYSKSLSKLA-N 709
            :.:.:....:|.|::::...||              :|     |||.:  ::..:|.:..|.: .
  Fly  1748 EGQAEANLRQLPRHLREFAKFSTSEQLPDGAQMERHEE-----QERREEATDNAHSSATKKTSIV 1807

  Fly   710 KLNKAGR-------EIPGSVADAWRGVATEMESRSDIHRQLAASLTDEL---------------- 751
            |..|..|       |.||..:...||  .....||...|.::.::..||
  Fly  1808 KTYKVSRLPPSVQGEFPGQFSGGNRG--RLYRERSQTARLVSHNIPLELTSNHSSSPDSDFNPGC 1870

  Fly   752 ----------------------------VKPL--------------------------KIVVEGH 762
                                        ::||                          |.:.:..
  Fly  1871 GSSPAPGSSTQSSIPSLVQSPTPAPPPPIEPLNPSSSTAGGILGTALLLGLSLLTAWNKFIYKVK 1935

  Fly   763 HKARKAVESNVDKAARV--LG-----------------------------EW------------- 783
            |:.....|:..|:..::  ||                             ||
  Fly  1936 HEYMSEPETGSDRPRKMAQLGRRQYDGIGPVTNDGMPIILRSEVKEPHQHEWYKRLYQTIHKQKN 2000

  Fly   784 --------RASEAKAKKASHTAARENEKLQD---AMLDVRIQKSPSIALLHQGPNKQAAEKELKS 837
                    :...|:....|:....|.|...|   :.:..|.|....:    |..:.....:.|..
  Fly  2001 GDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRV----QSVSSAVNVRNLNQ 2061

  Fly   838 AEKDCVKLDNKRKKAEEAVKR--ADVEYYTL--CVRSERARVDW---EMAVLRGSAQLQSSEQQR 895
            .||....:.|..|.|:.:.|.  ..:|.||.  ...||:.:.:|   .|.:..|:.     ||.:
  Fly  2062 DEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWWDEVMDIFNGNL-----EQSK 2121

  Fly   896 L------GNMHNFAQQYARLISDMNPILG----GLSTRLQPQLDACNVAKDMQVVRHIRRNSEGP 950
            |      ||:.....:.:...||.|.:..    .:|:.|.|       .:..|..:.::...|.|
  Fly  2122 LSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSP-------VEQKQAYKSLQAGGEPP 2179

  Fly   951 SEQLLPDFYCEHTTLAMNRERRKHALIKLLQLVKTDLERER---------RSRDGLRGLSQ---- 1002
                                        ||...|...|:.|         ..:..::|||.
  Fly  2180 ----------------------------LLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFP 2216

  Fly  1003 -----------------SLNHQEHQNITDKLYHIRSMLTYLEGARLKLHSALLELDHKPRATHPL 1050
                             .:.|::.||::::...||.
  Fly  2217 YSTDTVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQ----------------------------- 2252

  Fly  1051 AQHI----HITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELPDENCSH 1111
            |:|:    |..|.|..||:  |:..|..::.|.....|.        :.|..|..|:.|
  Fly  2253 AEHMQKLYHEERRRKYLQE--LQDMNSRRHTDNFTPSQK--------SPIALNRYDDFP------ 2301

  Fly  1112 LHSSSHSNNNSNGSCTDVS--SVVKPFNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLANLQ 1174
                           |||:  |:|.|  ::.:....||..|.....:......:.::.:..||..
  Fly  2302 ---------------TDVTLKSLVGP--KTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWY 2349

  Fly  1175 DGHHNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQP 1239
            :|.||..                   .....:.:.|..|:|....|.:...:.|.......|.|.
  Fly  2350 EGEHNAM-------------------IGLLPASYVEIVSRDGARTPSKRPSEGQARAKYNFQAQS 2395

  Fly  1240 LLQNPTINGQVQT------QHFYQNAQELQKG--------------------------------- 1265
            .::.....|::.|      .::::.....:||
  Fly  2396 GIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTDIGAEDIAARTTTVITSQSTTN 2460

  Fly  1266 -------------------QKNGSVPILGRCK-----------------------ALYSYTPKLY 1288
                               .:||:.|..|..|                       |||.|.|:..
  Fly  2461 LRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLAYRALYKYRPQNS 2525

  Fly  1289 DELELSPGDIIEVHAKQDDGWWLGALRNH--IGIFPATYVE 1327
            |||||..||::.|..|.||||::|..:..  .|.||..|||
  Fly  2526 DELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVE 2566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	61/406 (15%)
Nost	NP_001285029.1	SH3_Nostrin	1276..1328	CDD:212757	26/77 (34%)
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	2/43 (5%)
		SH3_Sorbs_1	2315..2367	CDD:212715	8/70 (11%)
		SH3_Sorbs_2	2384..2436	CDD:212716	7/51 (14%)
		SH3_Sorbs_3	2514..2567	CDD:212714	25/53 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I3230
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR14167
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.100