Protein Alignment Nost and Nostrin

DIOPT Version :10

• Sequence 1: NP_001285029.1
• Gene: Nost / 8673992
• FlyBaseID: FBgn0259734
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_853525.3
• Gene: Nostrin / 329416
• MGIID: 3606242
• Length: 506
• Species: Mus musculus
• Alignment Length: 671
• Identity: 158/671 - (23%)
• Similarity: 259/671 - (38%)
• Gaps: 201/671 - (29%)

  Fly   669 FEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREI-PGSVADAWRGVATE 732
            ::.|:.:.:.|.:|.|::..|||:||:.|:.|:|.|.|||.:|:||.:.. ...::.||...:..
Mouse    14 YKSLKEFAQHGDNFCKQITSVLQQRANLEISYAKGLQKLAVRLSKALQSTKKNCLSTAWAWASES 78

  Fly   733 MESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAAR-VLGEWRASEAKAKKASHT 796
            |:|.:|:|::|..::..|.:||...|:....|.||::::.|:|.|. |:..|. .:.||||....
Mouse    79 MKSAADLHQKLGKAIELEAIKPTHQVLSMQEKKRKSLDNEVEKTANLVINNWN-QQIKAKKKLMM 142

  Fly   797 AARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKSAEKDCVKLDNKRKKAEEAVKRADV 861
            :.:::|                 ||.|.   .:::::.|...||.  ||.||.||:.|.:::.|.
Mouse   143 STKKHE-----------------ALFHL---VESSKQSLTQKEKQ--KLLNKLKKSTEKLEKEDE 185

  Fly   862 EYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFAQQYARLISDMNPILGGLSTRLQP 926
            .||...:.....|:.||..:......:...|::|:..:.|...||::.||.....|....|::..
Mouse   186 SYYQKNMAGYSTRLKWESTLENCYKSMLELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHC 250

  Fly   927 QLDACNVAKDMQVVRHIRR--NSEGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLVKTDLER 989
            .:...:|.||:|.:.....  :.|..||.||.|::.|.....|::||||..|...|..::.|:|:
Mouse   251 AISKVDVEKDIQALMEETAILSIENKSELLLADYFEEDPKNPMDKERRKSLLKPKLGRLQRDIEK 315

  Fly   990 ERRSRDGLR------GLSQSLNHQEHQNITDKLYHIRSM-LTYLEGARLKLHSALLELDHKPRAT 1047
            ..|.::||.      ..|.|.:..:.|...:.|....|: |..|:....||.|.|.:|:.:|:..
Mouse   316 ASRDKEGLERKLKALASSSSFSDAKSQKDMETLMDENSLKLDLLQANSYKLSSVLADLEQRPKPC 380

  Fly  1048 HPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELPDENCSHL 1112
            ||.:..|.                .| |..:.|.|
Mouse   381 HPCSTCIF----------------KW-KEKEHSHT------------------------------ 398

  Fly  1113 HSSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLANLQDGH 1177
                               .||             .|:|.:......|     :||..|
Mouse   399 -------------------YVK-------------ISRPLLTKRLEKA-----ESKAPA------ 420

  Fly  1178 HNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQ 1242
                                 ||.|                   .|...|              .
Mouse   421 ---------------------GGQN-------------------NPSSSP--------------S 431

  Fly  1243 NPTINGQVQTQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDD 1307
            ..|::         |.::.|              |||||::..:..|||.|..|||:.||.|:::
Mouse   432 GSTVS---------QASKHL--------------CKALYTFQARQDDELNLEKGDIVTVHEKKEE 473

  Fly  1308 GWWLGALRNHIGIFPATYVEE 1328
            |||.|:|:...|.|||.||||
Mouse   474 GWWFGSLKGKRGHFPAAYVEE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	67/240 (28%)
		SH3_Nostrin	1276..1328	CDD:212757	26/51 (51%)
Nostrin	NP_853525.3	F-BAR_NOSTRIN	8..250	CDD:153342	71/258 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..435		9/86 (10%)
		SH3_Nostrin	443..494	CDD:212757	26/50 (52%)