Protein Alignment Nost and Nostrin

DIOPT Version :10

• Sequence 1: NP_001285029.1
• Gene: Nost / 8673992
• FlyBaseID: FBgn0259734
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_001019431.1
• Gene: Nostrin / 311111
• RGDID: 727920
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 156/671 - (23%)
• Similarity: 260/671 - (38%)
• Gaps: 201/671 - (29%)

  Fly   669 FEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREI-PGSVADAWRGVATE 732
            ::.|:.:.:.|.:|.|::..|||:||:.|:.|:|.|.|||.||:||.:.. ...::.||...:..
  Rat    14 YKSLKEFAQNGDNFCKQITSVLQQRANLEISYAKGLQKLAVKLSKALQSTKKNCLSTAWAWASES 78

  Fly   733 MESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAAR-VLGEWRASEAKAKKASHT 796
            |:|.:|:|::|..::..|.:||...|:....|.||::::.|:|:|. |:..|. .:.||||....
  Rat    79 MKSAADLHQKLGKAIELEAIKPTHQVLSMQEKKRKSLDNEVEKSANLVINNWN-QQIKAKKKLMM 142

  Fly   797 AARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKSAEKDCVKLDNKRKKAEEAVKRADV 861
            :.:::|                 ||.|.   .:::::.:...||.  ||.||.||:.|.:::.|.
  Rat   143 STKKHE-----------------ALFHL---IESSKQSMTQKEKQ--KLLNKLKKSTEKLEKEDE 185

  Fly   862 EYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFAQQYARLISDMNPILGGLSTRLQP 926
            .||...:.....|:.||..:.:....:...|::|:..:.|...||::.||.....|....|::..
  Rat   186 SYYQKNMAGYSTRLKWESTLEKCYKSMLELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHC 250

  Fly   927 QLDACNVAKDMQVVRHIRR--NSEGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLVKTDLER 989
            .:...:|.||:|.:.....  :.|..||.||.|::.|.....|::||||..:...|..::.|:|:
  Rat   251 AISKVDVEKDIQALMEETAVLSLENKSELLLADYFEEDPKNPMDKERRKSLIKPKLWRLQKDIEK 315

  Fly   990 ERRSRDGLR------GLSQSLNHQEHQNITDKLYHIRSM-LTYLEGARLKLHSALLELDHKPRAT 1047
            ..|.::||.      ..|.|.:..:.|...:.|....|: |..|:....||.:.|.:|:.:|:..
  Rat   316 ASRDKEGLEQKLKALASSASFSDAKSQKDAETLMDENSLKLDLLQANSYKLSTVLADLEQRPKPC 380

  Fly  1048 HPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELPDENCSHL 1112
            ||.:..|...:::                                                 .|.
  Rat   381 HPCSNCIFKWKEK-------------------------------------------------EHS 396

  Fly  1113 HSSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLANLQDGH 1177
            |                 |.||             .|:|.:......|     :||..|    |.
  Rat   397 H-----------------SYVK-------------ISRPLLTKRLEKA-----ESKAPA----GE 422

  Fly  1178 HNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQ 1242
            .||..         |.|   .|.|..|.
  Rat   423 QNNPS---------SSR---PGSSVSQG------------------------------------- 438

  Fly  1243 NPTINGQVQTQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDD 1307
                |.|:                          |||||::..:..|||.|..|||:.:|.|:::
  Rat   439 ----NNQL--------------------------CKALYTFQARQDDELNLEKGDIVTIHEKKEE 473

  Fly  1308 GWWLGALRNHIGIFPATYVEE 1328
            |||.|:|....|.|||.||||
  Rat   474 GWWFGSLNGKKGHFPAAYVEE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	67/240 (28%)
		SH3_Nostrin	1276..1328	CDD:212757	25/51 (49%)
Nostrin	NP_001019431.1	BAR	8..250	CDD:472257	71/258 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..437		11/44 (25%)
		SH3_Nostrin	443..494	CDD:212757	25/50 (50%)