Protein Alignment Nost and cdc15

DIOPT Version :10

• Sequence 1: NP_001285029.1
• Gene: Nost / 8673992
• FlyBaseID: FBgn0259734
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_593322.1
• Gene: cdc15 / 2541975
• PomBaseID: SPAC20G8.05C
• Length: 927
• Species: Schizosaccharomyces pombe
• Alignment Length: 1140
• Identity: 216/1140 - (18%)
• Similarity: 367/1140 - (32%)
• Gaps: 401/1140 - (35%)

  Fly   372 VQNLHRSELKVYLHKSNSVALDMNVTAPAKLGLDLNLPELPELYGASELSLAASDNKENLPAVKP 436
            |..:.:||...|:.|| ||....|.......|:|       .|...::.||:..::.:...|.:.
pombe     3 VNGVSQSEAAPYVTKS-SVKFRDNFWGSEDAGMD-------ALMSRTKSSLSVLESIDEFYAKRA 59

  Fly   437 SAER-------------SPIPNGG-----FMAQQPHFKSLDSFH------LNT------RSHSNQ 471
            |.||             :.||..|     .::.:....|:...|      :||      |.:.:|
pombe    60 SIEREYASKLQELAASSADIPEVGSTLNNILSMRTETGSMAKAHEEVSQQINTELRNKIREYIDQ 124

  Fly   472 SSQQ-----SSRQSLACSSSNGEYDFDLKSVSYQ-SLNAQNLF------VSIDELQELTRQINET 524
            :.||     ::.:.|....:..|.|...|..:|: |.|..|.:      ::..||.:...:|.:.
pombe   125 TEQQKVVAANAIEELYQKKTALEIDLSEKKDAYEYSCNKLNSYMRQTKKMTGRELDKYNLKIRQA 189

  Fly   525 EDFGKEIDLEYCAHRDQLRPSERRITLLKNKNQTLINFNHNKEKLRKGWHGMKHWLGEEGSKIKE 589
            ....|::|.||                 :..|:.|:...             :.|: :..:::.:
pombe   190 ALAVKKMDAEY-----------------RETNELLLTVT-------------REWI-DRWTEVCD 223

  Fly   590 AVRQQTPLKRLAQSRSNLNQSTADASRQSMSPERTQRDVTESCEDVTERTEMESSMSHRNSEEDL 654
            |      .:.:.:.|....::...|....:|....:.|  ||||.:  |..:|::    |.:||:
pombe   224 A------FQHIEEYRLEFLKTNMWAYANIISTACVKDD--ESCEKI--RLTLENT----NIDEDI 274

  Fly   655 SPHAKRFKDEGQN----GFEELRRYVKQGG---DFSKELIF------------------------ 688
            :   :..::||..    ...|...|.|:.|   |.. :||.
pombe   275 T---QMIQNEGTGTTIPPLPEFNDYFKENGLNYDID-QLISKAPSYPYSSSRPSASASLASSPTR 335

  Fly   689 -----VLQERADSELIYSKSLSKLANKLNKAGREIPGSVADAWRGVAT----EMESR------SD 738
                 ...|...||::.|...|.|.:.:.....|....|.:....:..    |.||:      |.
pombe   336 SAFRPKTSETVSSEVVSSPPTSPLHSPVKPVSNEQVEQVTEVELSIPVPSIQEAESQKPVLTGSS 400

  Fly   739 IHRQLAASLTDEL-VKPL-KIVVEGHHKARKAVESNVDKAARVLGEWRASEAKAKKASHTA-ARE 800
            :.|....|.|.|: .:|| .:.|...|.|...|:: :..|..:     :.|.|..|.|..| .::
pombe   401 MRRPSVTSPTFEVAARPLTSMDVRSSHNAETEVQA-IPAATDI-----SPEVKEGKNSENAITKD 459

  Fly   801 NEKLQDAMLDVRIQ------KSPSIALLHQGPNKQAAEKELKSAEKDCVKLDNKRKKAEEAVKRA 859
            |:   |.:|..::|      :|..::....|...|.:...:            |||...|.:.|.
pombe   460 ND---DIILSSQLQPTATGSRSSRLSFSRHGHGSQTSLGSI------------KRKSIMERMGRP 509

  Fly   860 DVEYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFA-QQYARLISDMNPILGGLSTR 923
            ...:                   .||:......:........|| .|:|...|..:..|..:..|
pombe   510 TSPF-------------------MGSSFSNMGSRSTSPTKEGFASNQHATGASVQSDELEDIDPR 555

  Fly   924 LQPQLDACNVAKDMQVVRHIRRNSEGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLVKTDLE 988
            ....|   ||..:|..|      .|.|.|                               .|..|
pombe   556 ANVVL---NVGPNMLSV------GEAPVE-------------------------------STSKE 580

  Fly   989 RERRSRD----GLRGLSQSLNHQEHQNITDKL-----------------YHIR--SMLTYLEGAR 1030
            .::...|    .:..||.|:..::..::.|:.                 ||.|  |:.:.::|..
pombe   581 EDKDVPDPIANAMAELSSSMRRRQSTSVDDEAPVSLSKTSSSTRLNGLGYHSRNTSIASDIDGVP 645

  Fly  1031 LKLHSALLELDHKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITD 1095
            .|  |.|    ..|.|.|..||          :|:        :.|:..|||:|...
pombe   646 KK--STL----GAPPAAHTSAQ----------MQR--------MSNSFASQTKQVFG-------- 678

  Fly  1096 ITTNHEDELPDENCSHLHSSSHSNNNSNGSCTDV----SSVVKP-FNRSKSNIETNFTSQPKIIS 1155
                   |...|| |...|..||.:|.:.|.:.:    ||.::| |.||.|::...   |..::|
pombe   679 -------EQRTEN-SARESLRHSRSNMSRSPSPMLSRRSSTLRPSFERSASSLSVR---QSDVVS 732

  Fly  1156 TTNAAIAVSVKSKTLANLQDGHHNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEP 1220
            ...:..|                               |||:..|..:..|....:...:: .:|
pombe   733 PAPSTRA-------------------------------RGQSVSGQQRPSSSMSLYGEYNK-SQP 765

  Fly  1221 QQPQQQ---PQPL------QSQQQQQQPLLQN--------------------------------- 1243
            |...|:   |.||      .|..|.|:....|
pombe   766 QLSMQRSVSPNPLGPNRRSSSVLQSQKSTSSNTSNRNNGGYSGSRPSSEMGHRYGSMSGRSMRQV 830

  Fly  1244 ------------PTINGQVQTQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPG 1296
                        ||....||:::....|....:|:     ||||...|||.|..::.:|:....|
pombe   831 SQRSTSRARSPEPTNRNSVQSKNVDPRATFTAEGE-----PILGYVIALYDYQAQIPEEISFQKG 890

  Fly  1297 DIIEVHAKQDDGWWLGALRN----HIGIFPATYVE 1327
            |.:.|...|:||||.|.:.|    ..|:||:.:|:
pombe   891 DTLMVLRTQEDGWWDGEIINVPNSKRGLFPSNFVQ 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	54/300 (18%)
		SH3_Nostrin	1276..1328	CDD:212757	19/56 (34%)
cdc15	NP_593322.1	F-BAR_PombeCdc15_like	28..263	CDD:153335	47/282 (17%)
		KAR9	<597..821	CDD:430088	56/298 (19%)
		SH3	869..925	CDD:214620	19/55 (35%)