DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nost and Cd2ap

DIOPT Version :9

Sequence 1:	NP_001285029.1	Gene:	Nost / 8673992	FlyBaseID:	FBgn0259734	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_033977.3	Gene:	Cd2ap / 12488	MGIID:	1330281	Length:	637	Species:	Mus musculus

Alignment Length:	146	Identity:	41/146 - (28%)
Similarity:	69/146 - (47%)	Gaps:	25/146 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1193 DRGQADGGSNQQDSDF-DEFSSQDEDDEPQQPQQQPQPLQSQQQ-QQQPLLQNPTING------- 1248
            :.|..:|..|.:...| |.|..  |.....:|:....|::.::| ....|:|..:..|
Mouse    34 EEGWLEGELNGRRGMFPDNFVK--EIKRETEPKDDNLPIKRERQGNVASLVQRISTYGLPAGGIQ 96

  Fly  1249 -QVQTQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDDGWWLG 1312
             ..||:...:..::.|             ||.|:.|:|:..|||||..||:|:|..:.::|||.|
Mouse    97 PHPQTKAIKKKTKKRQ-------------CKVLFDYSPQNEDELELIVGDVIDVIEEVEEGWWSG 148

  Fly  1313 ALRNHIGIFPATYVEE 1328
            .|.|.:|:||:.:|:|
Mouse   149 TLNNKLGLFPSNFVKE 164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342
Nost	NP_001285029.1	SH3_Nostrin	1276..1328	CDD:212757	24/51 (47%)
Cd2ap	NP_033977.3	Interaction with ANLN and localization to the midbody. /evidence=ECO:0000250	1..175		41/146 (28%)
		SH3_CD2AP_1	3..58	CDD:212986	7/25 (28%)
		SH3_CD2AP_2	111..165	CDD:212987	26/67 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..209
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..254
		SH3_CD2AP_3	271..327	CDD:212989
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..455
		SH3-binding. /evidence=ECO:0000255	336..352
		SH3-binding. /evidence=ECO:0000255	378..397
		SH3-binding. /evidence=ECO:0000255	410..422
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1577081at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14167
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110