Protein Alignment Nost and NOSTRIN

DIOPT Version :10

• Sequence 1: NP_001285029.1
• Gene: Nost / 8673992
• FlyBaseID: FBgn0259734
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_001165102.1
• Gene: NOSTRIN / 115677
• HGNCID: 20203
• Length: 563
• Species: Homo sapiens
• Alignment Length: 743
• Identity: 168/743 - (22%)
• Similarity: 269/743 - (36%)
• Gaps: 270/743 - (36%)

  Fly   656 PHAKRFKDEGQNGFEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREIPG 720
            |:.|.:|:        |:.:.:.|.:|.|::..|||:||:.|:.|:|.|.|||:||:||.:....
Human     9 PYNKVYKN--------LKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKALQNTRK 65

  Fly   721 S-VADAWRGVATEMESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAAR-VLGEW 783
            | |:.||...:..|:|.:|:|::|..::..|.:||...|:....|.||::::.|:|.|. |:..|
Human    66 SCVSSAWAWASEGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNW 130

  Fly   784 RASEAKAKKASHTAARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKS-AEKDCVKLDN 847
            . .:.||||....:.:::|.|                       .|..|...:| .||:..||.|
Human   131 N-QQIKAKKKLMVSTKKHEAL-----------------------FQLVESSKQSMTEKEKRKLLN 171

  Fly   848 KRKKAEEAVKRADVEYYTLCVRSERARVDWEMAV------------------------------- 881
            |..|:.|.:::.|..||...:.....|:.||..:
Human   172 KLTKSTEKLEKEDENYYQKNMAGYSTRLKWENTLENCYQVTHSICLYAFWVKRAWGKCVSDLRYQ 236

  Fly   882 ---LRG--------------------SAQLQS---SEQQRLGNMHNFAQQYARLISDMNPILGGL 920
               |.|                    |..|||   .|::|:..:.|...||::.||.....|...
Human   237 DTFLPGNLPPLWFGYDIVKRLIMRLCSVCLQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTC 301

  Fly   921 STRLQPQLDACNVAKDMQVVRHIRR--NSEGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLV 983
            .|::...:...::.||:|.|.....  ::|..||.||.|::.|....||::||||..|...|..:
Human   302 HTQIHCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRL 366

  Fly   984 KTDLERERRSRDGLRGL------SQSLNHQEHQNITDKLYHIRSM-LTYLEGARLKLHSALLELD 1041
            :.|:|:..:.::||..:      :.|.:..:.|..|..|....:: |..||....||.|.|.||:
Human   367 QRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELE 431

  Fly  1042 HKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELPD 1106
            .:|:.:||.:..|...|::
Human   432 QRPQPSHPCSNSIFRWREK---------------------------------------------- 450

  Fly  1107 ENCSHLHSSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLA 1171
               .|.||              ...:.:||                             ..|.|.
Human   451 ---EHTHS--------------YVKISRPF-----------------------------LMKRLE 469

  Fly  1172 NLQDGHHNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQ 1236
            |:.              :..|..||::.||:                       .|.|
Human   470 NIV--------------SKASSGGQSNPGSS-----------------------TPAP------- 490

  Fly  1237 QQPLLQNPTINGQVQTQHFYQNAQELQKGQKNGSVPILGR-CKALYSYTPKLYDELELSPGDIIE 1300
                                            |:..:..| ||||||:..:..|||.|..|||:.
Human   491 --------------------------------GAAQLSSRLCKALYSFQARQDDELNLEKGDIVI 523

  Fly  1301 VHAKQDDGWWLGALRNHIGIFPATYVEE 1328
            :|.|::.|||.|:|....|.|||.||||
Human   524 IHEKKEGGWWFGSLNGKKGHFPAAYVEE 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	75/304 (25%)
		SH3_Nostrin	1276..1328	CDD:212757	27/52 (52%)
NOSTRIN	NP_001165102.1	BAR	8..307	CDD:472257	82/329 (25%)
		HR1	353..431	CDD:469609	22/77 (29%)
		SH3_Nostrin	500..551	CDD:212757	26/50 (52%)