DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nost and NOSTRIN

DIOPT Version :9

Sequence 1:	NP_001285029.1	Gene:	Nost / 8673992	FlyBaseID:	FBgn0259734	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001165102.1	Gene:	NOSTRIN / 115677	HGNCID:	20203	Length:	563	Species:	Homo sapiens

Alignment Length:	743	Identity:	168/743 - (22%)
Similarity:	269/743 - (36%)	Gaps:	270/743 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   656 PHAKRFKDEGQNGFEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREIPG 720
            |:.|.:|:        |:.:.:.|.:|.|::..|||:||:.|:.|:|.|.|||:||:||.:....
Human     9 PYNKVYKN--------LKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKALQNTRK 65

  Fly   721 S-VADAWRGVATEMESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAAR-VLGEW 783
            | |:.||...:..|:|.:|:|::|..::..|.:||...|:....|.||::::.|:|.|. |:..|
Human    66 SCVSSAWAWASEGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNW 130

  Fly   784 RASEAKAKKASHTAARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKS-AEKDCVKLDN 847
            . .:.||||....:.:::|.|                       .|..|...:| .||:..||.|
Human   131 N-QQIKAKKKLMVSTKKHEAL-----------------------FQLVESSKQSMTEKEKRKLLN 171

  Fly   848 KRKKAEEAVKRADVEYYTLCVRSERARVDWEMAV------------------------------- 881
            |..|:.|.:::.|..||...:.....|:.||..:
Human   172 KLTKSTEKLEKEDENYYQKNMAGYSTRLKWENTLENCYQVTHSICLYAFWVKRAWGKCVSDLRYQ 236

  Fly   882 ---LRG--------------------SAQLQS---SEQQRLGNMHNFAQQYARLISDMNPILGGL 920
               |.|                    |..|||   .|::|:..:.|...||::.||.....|...
Human   237 DTFLPGNLPPLWFGYDIVKRLIMRLCSVCLQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTC 301

  Fly   921 STRLQPQLDACNVAKDMQVVRHIRR--NSEGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLV 983
            .|::...:...::.||:|.|.....  ::|..||.||.|::.|....||::||||..|...|..:
Human   302 HTQIHCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRL 366

  Fly   984 KTDLERERRSRDGLRGL------SQSLNHQEHQNITDKLYHIRSM-LTYLEGARLKLHSALLELD 1041
            :.|:|:..:.::||..:      :.|.:..:.|..|..|....:: |..||....||.|.|.||:
Human   367 QRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELE 431

  Fly  1042 HKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELPD 1106
            .:|:.:||.:..|...|::
Human   432 QRPQPSHPCSNSIFRWREK---------------------------------------------- 450

  Fly  1107 ENCSHLHSSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLA 1171
               .|.||              ...:.:||                             ..|.|.
Human   451 ---EHTHS--------------YVKISRPF-----------------------------LMKRLE 469

  Fly  1172 NLQDGHHNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQ 1236
            |:.              :..|..||::.||:                       .|.|
Human   470 NIV--------------SKASSGGQSNPGSS-----------------------TPAP------- 490

  Fly  1237 QQPLLQNPTINGQVQTQHFYQNAQELQKGQKNGSVPILGR-CKALYSYTPKLYDELELSPGDIIE 1300
                                            |:..:..| ||||||:..:..|||.|..|||:.
Human   491 --------------------------------GAAQLSSRLCKALYSFQARQDDELNLEKGDIVI 523

  Fly  1301 VHAKQDDGWWLGALRNHIGIFPATYVEE 1328
            :|.|::.|||.|:|....|.|||.||||
Human   524 IHEKKEGGWWFGSLNGKKGHFPAAYVEE 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	75/304 (25%)
Nost	NP_001285029.1	SH3_Nostrin	1276..1328	CDD:212757	27/52 (52%)
NOSTRIN	NP_001165102.1	BAR	8..307	CDD:299863	82/329 (25%)
		HR1	353..431	CDD:294066	22/77 (29%)
		SH3_Nostrin	500..551	CDD:212757	26/50 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H43142
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006524
OrthoInspector	1	1.000	-	-		oto89985
orthoMCL	1	0.900	-	-		OOG6_108098
Panther	1	1.100	-	-	O	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4981
SonicParanoid	1	1.000	-	-		X5500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.900