DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nost and nostrin

DIOPT Version :9

Sequence 1:	NP_001285029.1	Gene:	Nost / 8673992	FlyBaseID:	FBgn0259734	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001107076.1	Gene:	nostrin / 100148449	ZFINID:	ZDB-GENE-070522-2	Length:	537	Species:	Danio rerio

Alignment Length:	670	Identity:	162/670 - (24%)
Similarity:	282/670 - (42%)	Gaps:	168/670 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   669 FEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREI-PGSVADAWRGVATE 732
            ::||:|..|.|..|.|||:.|.|:|::.|:.|||.|.|:|.||.|..:|: ..|...||..::.|
Zfish    14 YQELKRISKNGEFFCKELLAVFQQRSELEINYSKGLQKIAGKLLKVSKEMSDNSTYHAWSFISDE 78

  Fly   733 MESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAAR-VLGEWRASEAKAKKASHT 796
            |.:.:|.||.|..:|..::::.::.:::.|.|.::.:::.|:|:.: ||..| :.:.|.||....
Zfish    79 MFASADAHRILGNALNQDVIQEIRQILDEHGKRKRPLDNAVEKSGKLVLTNW-SEQIKLKKKLIG 142

  Fly   797 AARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKSAEKDCVKLDNKRKKAEEAVKRADV 861
            ..||:|.|...     ::|           |||..      .||:..|:.|:..|:.|...|.|.
Zfish   143 LTREHEALFSF-----VEK-----------NKQIC------TEKEKQKMFNRLSKSAELQVRVDE 185

  Fly   862 EYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFAQQYARLISDMNPILGGLSTRLQP 926
            ||:...:.....|:..|..|......:|..|:||:..:.|...:|:..::..:..:.....::..
Zfish   186 EYFNTNMEGHHIRLKLENTVKTCYQIVQELEKQRIETLANTLNKYSLFMTVYSQTVIHSHKQIDQ 250

  Fly   927 QLDACNVAKDMQ-VVRHIRRNS-EGPSEQLLPDFYCEHTTLAMNRERRKHALIKLLQLVKTDLER 989
            .:...:|.||:| :|..:...: |..:|.|:.|::.|.....|.::|||.|:...||.::..:.:
Zfish   251 AVRRVDVEKDIQSLVEDVATTADENKAEFLMADYFEEEGKTMMGKDRRKDAIRTKLQRLEDWITK 315

  Fly   990 ERRSRDGLRGL----SQSLNHQEHQNI--TDKLYHIRSMLTYLEGARLKLHSALLELDHKPRATH 1048
            .:..|:||..:    ::..|....:|:  |::|         ||.|.|||.  |||..| .:.||
Zfish   316 SKTDREGLEKMVKVYTEQPNFSNQKNLEETEQL---------LEEAILKLD--LLEATH-CKLTH 368

  Fly  1049 PLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHEDELPDENCSHLH 1113
            .||:                     ::...||:         |..:|..|..:    :::|.|
Zfish   369 SLAE---------------------IEGKPKSR---------HRFSDSITKWK----EKDCEH-- 397

  Fly  1114 SSSHSNNNSNGSCTDVSSVVKPFNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLANLQDGHH 1178
                          .|..:.:|....|    |.|.|:..:.:|.:
Zfish   398 --------------SVVQLSRPVRIKK----TPFRSRQSMRATVS-------------------- 424

  Fly  1179 NNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQN 1243
                      |..|...:..|     ::..:|.::.|..                        :|
Zfish   425 ----------NETSPSPEGTG-----ENPLNEATNSDGQ------------------------KN 450

  Fly  1244 PTINGQVQTQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDDG 1308
            ..:||.|..   |::       .|...:..:||||||||:..:..|||.::.||::|:..|.|.|
Zfish   451 GPVNGSVSE---YED-------DKGAELCCIGRCKALYSFASEREDELNINEGDVLEIFEKDDTG 505

  Fly  1309 WWLGALRNHIGIFPATYVEE 1328
            ||.|.|....|:||:|||||
Zfish   506 WWFGELNGQRGLFPSTYVEE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	70/240 (29%)
Nost	NP_001285029.1	SH3_Nostrin	1276..1328	CDD:212757	26/51 (51%)
nostrin	NP_001107076.1	F-BAR_NOSTRIN	8..250	CDD:153342	70/258 (27%)
		HR1	298..>338	CDD:294066	9/39 (23%)
		SH3_Nostrin	473..525	CDD:212757	26/51 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8840
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H43142
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006524
OrthoInspector	1	1.000	-	-		oto41278
orthoMCL	1	0.900	-	-		OOG6_108098
Panther	1	1.100	-	-	O	PTHR14167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4981
SonicParanoid	1	1.000	-	-		X5500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.940