DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42638 and Mcoln1

DIOPT Version :9

Sequence 1:	NP_001163472.1	Gene:	CG42638 / 8673965	FlyBaseID:	FBgn0261361	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_444407.1	Gene:	Mcoln1 / 94178	MGIID:	1890498	Length:	580	Species:	Mus musculus

Alignment Length:	605	Identity:	226/605 - (37%)
Similarity:	341/605 - (56%)	Gaps:	82/605 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VVPMPISAGSGTAPPSVDGREEQPEFPGSSAASYQEERMRRKLQFFFMNPIEKWQAKRKFPYKFV 121
            :.|.|   |.||..    |....|..|      .:||.:||:|::|||:|.:|::||.:.|.|.:
Mouse    16 LTPNP---GYGTQV----GTSPAPTTP------TEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLM 67

  Fly   122 VQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGW-DSSREVESYPPAVGPFALYLKS 185
            :|:|||.:||:||.||..|....:.:..:|..||.||||.|: |.|.:.         ||.|.:.
Mouse    68 LQVVKILVVTVQLILFGLSNQLVVTFREENTIAFRHLFLLGYSDGSDDT---------FAAYTQE 123

  Fly   186 EFFDTVQYAVNGYANVSR-SIGPYDY------PTPNNTMPPLKLCLQNYREGTIFGFNESYIFDP 243
            :.:..:.|||:.|..:.. |:|.|.|      |..|.:  .|.||.:.|..|.:...|:::..||
Mouse   124 QLYQAIFYAVDQYLILPEISLGRYAYVRGGGGPWANGS--ALALCQRYYHRGHVDPANDTFDIDP 186

  Fly   244 HIDEVCERL-----PPNVTT------IGVENYLRQRDVEVNFASLVSAQLTFKIKTVNFKA--NG 295
            .:...|.::     ||::.:      .|..:|   :::.:.|..|::..:.|::||:|.::  |.
Mouse   187 RVVTDCIQVDPPDRPPDIPSEDLDFLDGSASY---KNLTLKFHKLINVTIHFQLKTINLQSLINN 248

  Fly   296 GPLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRLKC-------HGATDFISDANFDSMLRSV 353
               ..|||:.|.|.|||:|:.|.|::.:.|:.:....:|       ||          |:..|.:
Mouse   249 ---EIPDCYTFSILITFDNKAHSGRIPIRLETKTHIQECKHPSVSRHG----------DNSFRLL 300

  Fly   354 LNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWYIMIIFNDVLL 418
            .::.|:|||:|||.||.|:|.|.:||:...|.|...:.|:|:|...||||||.|||:::.:|||.
Mouse   301 FDVVVILTCSLSFLLCARSLLRGFLLQNEFVVFMWRRRGREISLWERLEFVNGWYILLVTSDVLT 365

  Fly   419 IIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYNVVILTLKKAAPKILRF 483
            |.|:.:|..||.:.|.  .:|.||:.||...||||.||:|||.||..||::|.||:.|.|.::||
Mouse   366 ISGTVMKIGIEAKNLA--SYDVCSILLGTSTLLVWVGVIRYLTFFHKYNILIATLRVALPSVMRF 428

  Fly   484 LIAALLIYAGFVFCGWLILGPYHMKFRSLATTSECLFALINGDDMFATFATLSSK---ATWLWWF 545
            .....:||.|:.||||::|||||:|||||:..|||||:||||||||.|||.:.::   ::.:|.|
Mouse   429 CCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGHSSLVWLF 493

  Fly   546 CQIYLYSFISLYIYVVLSLFIAVIMDAYDTIKAYYKDGFPTTDLKAFVGTRTAEDISSGVFMTDL 610
            .|:||||||||:||:|||||||:|..||||||.....|...::|:|:: .:..:..:||.|
Mouse   494 SQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGTGTEKSELQAYI-EQCQDSPTSGKF---- 553

  Fly   611 DDFDQTSFLDVVKSICCCGR 630
                :..........|||||
Mouse   554 ----RRGSGSACSLFCCCGR 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42638	NP_001163472.1	Ion_trans	403..578	CDD:278921	99/177 (56%)
Mcoln1	NP_444407.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		8/34 (24%)
		Dileucine motif, mediates targeting to lysosomes. /evidence=ECO:0000250\|UniProtKB:Q9GZU1	11..16		226/605 (37%)
		Interaction with phosphoinositides. /evidence=ECO:0000269\|PubMed:29019981	42..62		10/19 (53%)
		Extracellular/lumenal pore loop. /evidence=ECO:0000250\|UniProtKB:Q9GZU1	107..121		5/22 (23%)
		ELD_TRPML1	112..292	CDD:410966	47/196 (24%)
		PKD_channel	<388..524	CDD:400395	79/135 (59%)
		Selectivity filter. /evidence=ECO:0000269\|PubMed:29019981	469..474		4/4 (100%)
		Required for palmitoylation and association with membranes. /evidence=ECO:0000250\|UniProtKB:Q9GZU1	565..567		1/1 (100%)
		Dileucine internalization motif, mediates AP2 complex-dependent internalization. /evidence=ECO:0000250\|UniProtKB:Q9GZU1	573..578
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846807
Domainoid	1	1.000	213	1.000	Domainoid score	I2739
eggNOG	1	0.900	-	-		E1_KOG3733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49191
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		otm43480
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	1	1.100	-	-	O	PTHR12127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3353
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790