DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42638 and Mcoln2

DIOPT Version :9

Sequence 1:	NP_001163472.1	Gene:	CG42638 / 8673965	FlyBaseID:	FBgn0261361	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_080932.2	Gene:	Mcoln2 / 68279	MGIID:	1915529	Length:	566	Species:	Mus musculus

Alignment Length:	550	Identity:	211/550 - (38%)
Similarity:	324/550 - (58%)	Gaps:	39/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 GREEQPEFPG--------------SSAAS----YQEERMRRKLQFFFMNPIEKWQAKRKFPYKFV 121
            |.||..:.|.              |:.||    .:||.:|..|:|:||:|.||::|:|:.|:|..
Mouse     3 GDEETLDLPAWNRVPDLTWGPHHRSAMASLDSEVREECLREDLKFYFMSPCEKYRARRQIPWKLG 67

  Fly   122 VQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGWDSSREVESYPPAVGPFALYLKSE 186
            :||:||.:||.||..|..|....:.:..||..||.||||:|: |..:.:.|     ..::|.:..
Mouse    68 LQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGF-SGVDEDDY-----SCSIYTQEN 126

  Fly   187 FFDTVQYAVNGYANVSR-SIGPYDYPTPNNTMPPLKLCLQNYREGTIFGFNESYIFDPHIDEVCE 250
            .::::.:|:..|.::.. |:....|....:....||:|.|:|:.|.:|..||:...|..|:..|.
Mouse   127 TYESIFFAIKQYRHLKNISLATLGYGESEDNRTGLKVCKQHYKTGAMFSSNETLNIDSDIETDCI 191

  Fly   251 RLPPNVTTIGVENYLRQRDVEVNFASLVSAQLTFKIKTVNFKANGGPLSAPDCFRFDISITFNNR 315
            .|...|.|...|::.:.....::|..||...::|.:|.::.:|... ...|||:.|..:|||:|.
Mouse   192 HLDLQVLTTEPEDWAQTSFFRLDFYRLVQVDISFALKGIDLQAVHS-REIPDCYLFQNTITFDNT 255

  Fly   316 DHDGQMLLSLDAEATRLKCHGATDFISDANFDSMLRS-----VLNIFVLLTCALSFALCTRALWR 375
            .|.|::.:.|::||...:|....  ||    .|..||     |.::||::.|..|..||||::..
Mouse   256 AHSGKIKIYLNSEANIEECKNMN--IS----GSTQRSTHYLLVFDVFVIMICLASLILCTRSIVL 314

  Fly   376 AYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWYIMIIFNDVLLIIGSALKEQIEGRYLVVDQWDT 440
            |..||...:|||..::.:.:....:.||||.||:::..:|::.||||.||.:|:.:.|.  .:|.
Mouse   315 ALRLRKRFLNFFLEKYKQRVCGADQWEFVNGWYVLVTISDLMTIIGSILKMEIKAKKLT--NYDV 377

  Fly   441 CSLFLGIGNLLVWFGVLRYLGFFKTYNVVILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPY 505
            ||:.||...|.||.||:||||:|:||||:|||::.:.||:|||...|.:||.|:.||||::||||
Mouse   378 CSILLGTSTLFVWVGVIRYLGYFQTYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPY 442

  Fly   506 HMKFRSLATTSECLFALINGDDMFATFATLSSKATWLWWFCQIYLYSFISLYIYVVLSLFIAVIM 570
            |.||.:|...:||||:|:||||||||||.:..|:..:|.|.::||||||||:||:|||||||:|.
Mouse   443 HEKFENLNIVAECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMVLSLFIALIT 507

  Fly   571 DAYDTIKAYYKDGFPTTDLKAFVGTRTAED 600
            |:|.|||.|.:.|||.|||:.|:....::|
Mouse   508 DSYHTIKKYQQHGFPETDLQKFLKESGSKD 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42638	NP_001163472.1	Ion_trans	403..578	CDD:278921	97/174 (56%)
Mcoln2	NP_080932.2	Extracellular/lumenal pore loop. /evidence=ECO:0000250\|UniProtKB:Q9GZU1	107..123		3/21 (14%)
		PKD_channel	<380..513	CDD:285288	78/132 (59%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:F6RG56	461..464		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846808
Domainoid	1	1.000	213	1.000	Domainoid score	I2739
eggNOG	1	0.900	-	-		E1_KOG3733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49191
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		otm43480
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	1	1.100	-	-	O	PTHR12127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760