Sequence 1: | NP_001163472.1 | Gene: | CG42638 / 8673965 | FlyBaseID: | FBgn0261361 | Length: | 652 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_065394.1 | Gene: | MCOLN1 / 57192 | HGNCID: | 13356 | Length: | 580 | Species: | Homo sapiens |
Alignment Length: | 632 | Identity: | 234/632 - (37%) |
---|---|---|---|
Similarity: | 351/632 - (55%) | Gaps: | 97/632 - (15%) |
- Green bases have known domain annotations that are detailed below.
Fly 51 STPVAP--------VVPMP---ISAGSGTAPPSVDGREEQPEFPGSSAASYQEERMRRKLQFFFM 104
Fly 105 NPIEKWQAKRKFPYKFVVQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGWDSSREV 169
Fly 170 ESYPPAVGPFALYLKSEFFDTVQYAVNGY-ANVSRSIGPYDY------PTPNNTMPPLKLCLQNY 227
Fly 228 REGTIFGFNESYIFDPHIDEVC------ERLPP----NVTTIGVENYLRQRDVEVNFASLVSAQL 282
Fly 283 TFKIKTVNFKA--NGGPLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRLKC-------HGAT 338
Fly 339 DFISDANFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEF 403
Fly 404 VNFWYIMIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYNV 468
Fly 469 VILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLATTSECLFALINGDDMFATFA 533
Fly 534 TLSS---KATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTIKAYYKDGFPTTDLKAFVGT 595
Fly 596 RTAEDISSGVFMTDLDDFDQTSFLDVVKSICCCGRCGRHQEPAQPNS 642 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
CG42638 | NP_001163472.1 | Ion_trans | 403..578 | CDD:278921 | 99/177 (56%) |
MCOLN1 | NP_065394.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..38 | 11/51 (22%) | |
Dileucine motif, mediates targeting to lysosomes. /evidence=ECO:0000269|PubMed:16497227 | 11..16 | 0/4 (0%) | |||
Interaction with phosphoinositides. /evidence=ECO:0000269|PubMed:22733759 | 42..62 | 10/19 (53%) | |||
Extracellular/lumenal pore loop. /evidence=ECO:0000305|PubMed:28112729 | 107..121 | 4/21 (19%) | |||
ELD_TRPML1 | 112..292 | CDD:410966 | 51/194 (26%) | ||
PKD_channel | <388..524 | CDD:400395 | 79/135 (59%) | ||
Selectivity filter. /evidence=ECO:0000305|PubMed:29019983 | 469..474 | 4/4 (100%) | |||
Required for palmitoylation and association with membranes. /evidence=ECO:0000269|PubMed:16497227 | 565..567 | 1/1 (100%) | |||
Dileucine internalization motif, mediates AP2 complex-dependent internalization. /evidence=ECO:0000269|PubMed:16497227 | 573..578 | 1/4 (25%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 1 | 0.930 | - | - | C165156405 | |
Domainoid | 1 | 1.000 | 208 | 1.000 | Domainoid score | I2860 |
eggNOG | 1 | 0.900 | - | - | E1_KOG3733 | |
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 1 | 1.050 | 415 | 1.000 | Inparanoid score | I1837 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 1 | 1.010 | - | - | QHG49191 | |
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 1 | 1.000 | - | - | FOG0001492 | |
OrthoInspector | 1 | 1.000 | - | - | otm41429 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_102454 | |
Panther | 1 | 1.100 | - | - | O | PTHR12127 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3353 |
SonicParanoid | 1 | 1.000 | - | - | X949 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 1 | 0.960 | - | - | ||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
14 | 13.790 |