Protein Alignment CG42638 and MCOLN3

DIOPT Version :9

• Sequence 1: NP_001163472.1
• Gene: CG42638 / 8673965
• FlyBaseID: FBgn0261361
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_011540041.2
• Gene: MCOLN3 / 55283
• HGNCID: 13358
• Length: 566
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 236/587 - (40%)
• Similarity: 349/587 - (59%)
• Gaps: 55/587 - (9%)

  Fly    69 APPSVDGREEQPEFPGSSAASYQEE-------------------RMRRKLQFFFMNPIEKWQAKR 114
            |.|........||...||.:|::||                   :|||||:||||||.||:.|:.
Human     6 AAPKPPAEMADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARG 70

  Fly   115 KFPYKFVVQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGWDSSREVESYPPAVGPF 179
            :.|:|..:||:||.:||:||.||..|....:.:..:|..||.||||:|: ..|..::|
Human    71 RKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGY-MDRMDDTY------- 127

  Fly   180 ALYLKSEFFDTVQYAVNGYANV-SRSIGPYDYPTPNNTMPPLKLCLQNYREGTIFGFNESYIFDP 243
            |:|.:|:.:|.:.:|||.|..: :.|:|.:.|.........:.:|...|:.|.|:..|:::..||
Human   128 AVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDP 192

  Fly   244 HIDEVCERLPPNVT-TIG--VENYLRQRDVEVNFASLVSAQLTFKIKTVNFKANGGPLSAPDCFR 305
            .|:..|..:.|:.. .||  .||.|   ::.::|..|::.:|.||:|.:|.:..... ..|||:.
Human   193 EIETECFFVEPDEPFHIGTPAENKL---NLTLDFHRLLTVELQFKLKAINLQTVRHQ-ELPDCYD 253

  Fly   306 FDISITFNNRDHDGQMLLSLDAEATRLKC---HGATDFISDANFDSMLRSVLNIFVLLTCALSFA 367
            |.::|||:|:.|.|::.:|||.:.:..:|   |.:.....:.::    ..:.:.||:|||.:|..
Human   254 FTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHY----MMIFDAFVILTCLVSLI 314

  Fly   368 LCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWYIMIIFNDVLLIIGSALKEQIEGRY 432
            ||.|::.|...|:...||||...:.||:|...::||||.||||||.:|:|.||||.||.:|:.:.
Human   315 LCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKS 379

  Fly   433 LVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYNVVILTLKKAAPKILRFLIAALLIYAGFVFC 497
            |.  .:|.||:.||...:|||.||:||||||..||::||||:.|.|.::||...|.:||.|:.||
Human   380 LT--SYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFC 442

  Fly   498 GWLILGPYHMKFRSLATTSECLFALINGDDMFATFATLSSKATWLWWFCQIYLYSFISLYIYVVL 562
            ||::|||||.|||||...|||||:||||||||||||.:..|:..:|.|.:|||||||||:||::|
Human   443 GWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMIL 507

  Fly   563 SLFIAVIMDAYDTIKAYYKDGFPTTDLKAFVGTRTAEDI-SSGVFMTDLDDFDQTSFLDVVKSIC 626
            |||||:|.|.|:|||.|.:||||.|:|:.|:.  ..:|: :||.:..: ||       ..|...|
Human   508 SLFIALITDTYETIKQYQQDGFPETELRTFIS--ECKDLPNSGKYRLE-DD-------PPVSLFC 562

  Fly   627 CC 628
            ||
Human   563 CC 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42638	NP_001163472.1	Ion_trans	403..578	CDD:278921	105/174 (60%)
MCOLN3	XP_011540041.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156403
Domainoid	1	1.000	208	1.000	Domainoid score	I2860
eggNOG	1	0.900	-	-		E1_KOG3733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10118
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1837
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49191
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		otm41429
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	1	1.100	-	-	LDO	PTHR12127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3353
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790