Protein Alignment CG42638 and mcoln1

DIOPT Version :9

• Sequence 1: NP_001163472.1
• Gene: CG42638 / 8673965
• FlyBaseID: FBgn0261361
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_001011347.1
• Gene: mcoln1 / 496811
• XenbaseID: XB-GENE-982338
• Length: 565
• Species: Xenopus tropicalis
• Alignment Length: 591
• Identity: 215/591 - (36%)
• Similarity: 327/591 - (55%)
• Gaps: 47/591 - (7%)

  Fly    43 LRRQVQLQSTPVAPVVPMPISAGSGTAPPSVDGREEQPEFPGSSAASYQEERMRRKLQFFFMNPI 107
            |||...|..:|...      |.......||.:......|||     |.:|.::||:|::|||:|.
 Frog     4 LRRSRSLSDSPKLS------SERRRLLSPSPNYGTRLCEFP-----SPEEVQLRRRLKYFFMSPC 57

  Fly   108 EKWQAKRKFPYKFVVQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGWDSSREVESY 172
            :|::||.:.|||..:|::||..||:||.||..|....:.:..:|..||.||||:.:....|
 Frog    58 DKFRAKGRKPYKLGLQLLKIMFVTVQLILFGLSNQMVVQFKEENTEAFKHLFLKDYTDDAE---- 118

  Fly   173 PPAVGPFALYLKSEFFDTVQYAVNGYANVS-RSIGPYDYPTPNNTMPPLKLCLQNYREGTIFGFN 236
                ..:|:|.:.:.::.:.|||..|.::| ::...|.|..|.| ...|.:|.|.||:|.|...|
 Frog   119 ----KTYAVYTQEDVYEHLYYAVEQYFSLSNQTTARYAYTRPFN-QSALSVCQQYYRKGHIDPAN 178

  Fly   237 ESYIFDPHIDEVCERLPPNVTTIGVENYLRQRDVEVNFASLVSAQLTFKIKTVNFKA--NGGPLS 299
            :::..||.:...|..|.|...:...:|:      .:.|..|::..:.|::|.:|.:.  |.   .
 Frog   179 DTFNIDPQVITNCLFLDPAEPSQSYKNF------TIKFHKLINLTVQFQLKAINIQTIINN---E 234

  Fly   300 APDCFRFDISITFNNRDHDGQMLLSLDAEATRLKCHGATDFISDANFDSMLRSVLNIFVLLTCAL 364
            .|||:.|.|:|.|:|:.|.|::.:.||.||...:|...:.:   ...|:..|...::.|:|:|.|
 Frog   235 IPDCYTFTITILFDNKAHSGKVKIQLDNEAKIKECKDPSVY---GRGDNHSRLAFDVLVILSCIL 296

  Fly   365 SFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWYIMIIFNDVLLIIGSALKEQIE 429
            ||.||.|::.|..||:.....|...:.|..:|...||||||.||:::|.:|||.:.|:.:|..||
 Frog   297 SFILCARSIVRGLLLQHEFAQFVHYRHGLTISLSDRLEFVNGWYLLLIISDVLTVSGTVMKIGIE 361

  Fly   430 GRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYNVVILTLKKAAPKILRFLIAALLIYAGF 494
            .:...  .:|.||:.||...||||.||:|||.||:.||::|:||:.|.|.::||.....:||.|:
 Frog   362 SKTFA--SYDVCSILLGTSTLLVWVGVIRYLSFFQKYNILIVTLRVALPNVIRFCCCVAVIYLGY 424

  Fly   495 VFCGWLILGPYHMKFRSLATTSECLFALINGDDMFATFATLSSKATWLWWFCQIYLYSFISLYIY 559
            .||||::|||||:|||:|:..|||||:||||||||.||:.:.:.:..:|.|.|:|||:||||:||
 Frog   425 CFCGWIVLGPYHVKFRTLSMVSECLFSLINGDDMFVTFSEMQNSSYLVWAFSQLYLYTFISLFIY 489

  Fly   560 VVLSLFIAVIMDAYDTIKAYYKDGFPTTDLKAFVG--TRTAEDISSGVFMTDLDDFDQTSFLDVV 622
            :|||||||:|..||:|||......|..::..|...  ....:..|||.|.:    .:.||    .
 Frog   490 MVLSLFIALITGAYETIKCQNSSDFSGSNDNALYQYIAECKDSPSSGKFRS----ANSTS----C 546

  Fly   623 KSICCC 628
            ...|||
 Frog   547 SMFCCC 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42638	NP_001163472.1	Ion_trans	403..578	CDD:278921	93/174 (53%)
mcoln1	NP_001011347.1	PKD_channel	<297..506	CDD:369653	105/210 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2977
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1835
OMA	1	1.010	-	-		QHG49191
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		otm48635
Panther	1	1.100	-	-	O	PTHR12127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3353
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100