DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42638 and mcoln2

DIOPT Version :9

Sequence 1:	NP_001163472.1	Gene:	CG42638 / 8673965	FlyBaseID:	FBgn0261361	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_957442.1	Gene:	mcoln2 / 394123	ZFINID:	ZDB-GENE-040426-692	Length:	561	Species:	Danio rerio

Alignment Length:	551	Identity:	213/551 - (38%)
Similarity:	322/551 - (58%)	Gaps:	25/551 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 SSAAS--YQEERMRRKLQFFFMNPIEKWQAKRKFPYKFVVQIVKIFLVTMQLCLFAHSRYNHINY 147
            :|.||  ..||::|..|:|:||:|.||::.:|:.|:|..|||.|||::|:||.||..:....::|
Zfish    20 TSVASDPMTEEKLRDDLRFYFMSPCEKYRTRRQLPWKLAVQIFKIFMITLQLILFGLNNQLVVSY 84

  Fly   148 TGDNRFAFSHLFLRGWDSSREVESYPPAVGPFALYLKSEFFDTVQYAVNGYANVSR-SIGPYDYP 211
            ..:|..||.:|||:|:....|.|.      ..::|.|...||::.|.::.||.:.. |:||..|.
Zfish    85 KEENLMAFKNLFLKGYSGVDEDEY------SISIYTKERVFDSLHYVLDQYAQLQNLSVGPISYA 143

  Fly   212 TPNNTMPPLKLCLQNYREGTIFGFNESYIFDPHIDEVCERLPPN-VTTIGVENYLRQRDVEVNFA 275
            ..|....|:.:|.::|:.|.:....:.|..:..::.||..:.|| :.|..:.|   ....|::|.
Zfish   144 EENGEFSPMIICKKSYKRGDVQPSEDVYDIEAQLEIVCLTVDPNSILTWRMNN---ASFFELDFY 205

  Fly   276 SLVSAQLTFKIKTVNFKANGGPLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRLKCHGATDF 340
            .||..::||.::.:|.:..... ..|||..|.:.|.|:|..|.|:|.|||..:|....|.. ...
Zfish   206 RLVGIEITFALEGINLQTVRSH-ELPDCCTFFVKIDFDNSCHSGKMKLSLGFDAVSSLCKN-WRI 268

  Fly   341 ISDANFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVN 405
            ...|..:::...:.:.||:|.|.:|..||||::..|..|.....:|....:..::..:.:.||:|
Zfish   269 SGTAQKNTLYLLIFDGFVILVCLISAILCTRSIILAVKLLQRFSSFCLDNYNHKVCEEDQREFLN 333

  Fly   406 FWYIMIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYNVVI 470
            .||:::|.:||:.||||.||.:|:.:.|.  .:|.||:.||...|:||.||:||||:|:.|||:|
Zfish   334 GWYVLVIISDVMAIIGSILKMEIQAKSLT--NYDVCSILLGTSTLMVWVGVIRYLGYFEKYNVLI 396

  Fly   471 LTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLATTSECLFALINGDDMFATFATL 535
            ||::.|.||:|||...|.:||.|:.||||::|||||.||..|:..:||||:|:||||||||||..
Zfish   397 LTMRAALPKVLRFCCCAGMIYLGYTFCGWIVLGPYHEKFEDLSRVAECLFSLVNGDDMFATFAQF 461

  Fly   536 SSKATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTIKAYYKDGFPTTDLKAFV-GTRTAE 599
            ..|.|.:|.|.::||||||||:||:|||||||:|.|||:|||.|...|||.|:|..|: |.:...
Zfish   462 EQKNTMVWLFSRVYLYSFISLFIYMVLSLFIALITDAYETIKGYQTTGFPMTELHWFLKGQKECF 526

  Fly   600 DISSGVFMTDLDDFDQTSFLDVVKSICCCGR 630
            .:.....|.  .:..|.|.|     :|||.|
Zfish   527 PLQGQEEME--PEMVQPSGL-----LCCCQR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42638	NP_001163472.1	Ion_trans	403..578	CDD:278921	100/174 (57%)
mcoln2	NP_957442.1	PLN03223	<370..517	CDD:215637	89/146 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592026
Domainoid	1	1.000	197	1.000	Domainoid score	I3054
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49191
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	1	1.100	-	-	O	PTHR12127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.850