Protein Alignment CG42638 and Mcoln1

DIOPT Version :9

• Sequence 1: NP_001163472.1
• Gene: CG42638 / 8673965
• FlyBaseID: FBgn0261361
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_006248816.1
• Gene: Mcoln1 / 288371
• RGDID: 1308953
• Length: 620
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 230/639 - (35%)
• Similarity: 346/639 - (54%)
• Gaps: 111/639 - (17%)

  Fly    65 GSGT------APPSVDGREEQPEFP--------GSSAASY---QEERMRRKLQFFFMNPIEKWQA 112
            |||.      ||.|.....||...|        |:|.|..   :||.:||:|::|||:|.:|::|
  Rat     9 GSGERGRREGAPGSATSETEQLLTPNPGYGTQAGTSPAPTTPPEEEDLRRRLKYFFMSPCDKFRA 73

  Fly   113 KRKFPYKFVVQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGW-DSSREVESYPPAV 176
            |.:.|.|.::|:|||.:||:||.||..|....:.:..:|..||.||||.|: |.|.:.
  Rat    74 KGRKPCKLMLQVVKILVVTVQLILFGLSNQLVVTFREENTIAFRHLFLLGYSDGSDDT------- 131

  Fly   177 GPFALYLKSEFFDTVQYAVNGYANVSR-SIGPYDY------PTPNNTMPPLKLCLQNYREGTIFG 234
              ||.|.:.:.:..:.|||:.|..:.. |:|.|.|      |..|.:  .|.||.:.|..|.:..
  Rat   132 --FAAYTREQLYQAIFYAVDQYLTLPEISLGRYAYVRGGGGPWANGS--ALALCQRYYHRGHVDP 192

  Fly   235 FNESYIFDPHIDEVCERL-----PPNVTT------IGVENYLRQRDVEVNFASLVSAQLTFKIKT 288
            .|:::..||.:...|.::     ||::.:      .|..:|   :::.:.|..|::..:.|::||
  Rat   193 ANDTFDIDPRVVTDCIQVDPPDRPPDIPSEDLDFLDGSTSY---KNITLKFHKLINVTIHFQLKT 254

  Fly   289 VNFKA--NGGPLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRLKC-------HGATDFISDA 344
            :|.::  |.   ..|||:.|.|.|||:|:.|.|::.:.|:.:....:|       ||
  Rat   255 INLQSLINN---EIPDCYTFSILITFDNKAHSGRIPIRLETQTHIQECKHPSVSRHG-------- 308

  Fly   345 NFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWYI 409
              |:..|.:.::.|:|||:|||.||.|:|.|.:||:...|.|...:.|:|:|...||||||.|||
  Rat   309 --DNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVVFMWRRRGREISLWERLEFVNGWYI 371

  Fly   410 MIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYN------- 467
            :::.:|||.|.|:.:|..||.:.|.  .:|.||:.||...||||.||:|||.||..||
  Rat   372 LLVTSDVLTISGTIMKIGIEAKNLA--SYDVCSILLGTSTLLVWVGVIRYLTFFHKYNTHESLYQ 434

  Fly   468 ------------------VVILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLAT 514
                              ::|.||:.|.|.::||.....:||.|:.||||::|||||:|||||:.
  Rat   435 GRTTGACPYLPIQLSPAVILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSM 499

  Fly   515 TSECLFALINGDDMFATFATLSS---KATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTI 576
            .|||||:||||||||.|||.:.:   :::.:|.|.|:||||||||:||:|||||||:|..|||||
  Rat   500 VSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTI 564

  Fly   577 KAYYKDGFPTTDLKAFVGTRTAEDISSGVFMTDLDDFDQTSFLDVVKSICCCGR 630
            |.....|...::|:|:: .:..:..:||.|        :.........:|||||
  Rat   565 KHPGGTGTEKSELQAYI-EQCQDSPTSGKF--------RRGSGSTCSLLCCCGR 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42638	NP_001163472.1	Ion_trans	403..578	CDD:278921	99/202 (49%)
Mcoln1	XP_006248816.1	PLN03223	<457..565	CDD:215637	64/107 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350336
Domainoid	1	1.000	212	1.000	Domainoid score	I2686
eggNOG	1	0.900	-	-		E1_KOG3733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1828
OMA	1	1.010	-	-		QHG49191
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		otm45544
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	1	1.100	-	-	O	PTHR12127
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.800