DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42638 and mcoln3a

DIOPT Version :9

Sequence 1:	NP_001163472.1	Gene:	CG42638 / 8673965	FlyBaseID:	FBgn0261361	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_021322333.1	Gene:	mcoln3a / 100334819	ZFINID:	ZDB-GENE-121116-4	Length:	542	Species:	Danio rerio

Alignment Length:	550	Identity:	203/550 - (36%)
Similarity:	315/550 - (57%)	Gaps:	43/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 ERMRRKLQFFFMNPIEKWQAKRKFPYKFVVQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSH 157
            |.:||||::|||:|.:|:..:.:.|:|.::||:||.::|:||..|..|....:.:..:|..||.|
Zfish    21 ESLRRKLKYFFMSPCQKYSTRGRIPWKMMLQILKIVIITVQLVSFGLSNEMMVTFKEENLIAFKH 85

  Fly   158 LFLRGW-DSSREVESYPPAVGPFALYLKSEFFDTVQYAVNGYANVSR-SIGPYDYPTPNNTMPPL 220
            .||:.: ||::.          :|||.|.|..|.:.|.:..|..:.. :||.......:....||
Zfish    86 FFLKNYKDSNKH----------YALYTKHEVHDHILYTIRRYLQLQNLTIGNQALEMIDGLATPL 140

  Fly   221 KLCLQNYREGTIFGFNESYIFDPHIDEVCERLPP--NVTTIGVENYLRQRDVEVNFASLVSAQLT 283
            .||.|.||...:...||::..|||::..|..:.|  .:||..:||.|   ::.::|..|::..:.
Zfish   141 SLCQQLYRHARVVPSNETFEIDPHVETECVSVYPLSPITTDSLENSL---NLTLDFQRLLAVNIY 202

  Fly   284 FKIKTVNFKANGGPLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRLKC-----HGATDFISD 343
            .|||.:|.:..... ..|||:.|.|:|.|:||.|.||:.:||.:......|     .|:|    |
Zfish   203 LKIKAINIQTVRHQ-ELPDCYDFSINIMFDNRAHSGQIKISLSSGVQINVCKDWNISGST----D 262

  Fly   344 ANFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWY 408
            ::|  .|..|.:..::..|.||..||||::...:||:.....|..||..|.:|:..||||:|.||
Zfish   263 SHF--ALIVVFDCLIICFCLLSLILCTRSVHTGFLLQTEYRRFMSSQHSKSVSWSERLEFINGWY 325

  Fly   409 IMIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYNVVILTL 473
            |:||.:|.|.|.||.||..|:.:.|.  .:|.||:.||...:|||.||:|||.||:.|.::||||
Zfish   326 ILIIISDALTIAGSILKICIQSKELT--SYDVCSILLGTATMLVWIGVMRYLSFFQKYYILILTL 388

  Fly   474 KKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLATTSECLFALINGDDMFATFATLSSK 538
            |.|.|.::||.|.|::||..:.||||::|||:|..||:.:..:.|||::||||::::||..|...
Zfish   389 KAALPNVIRFSICAVMIYLSYCFCGWIVLGPHHENFRTFSRVAGCLFSMINGDEIYSTFTKLREY 453

  Fly   539 ATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTIKAYYKDGFPTTDLKAFVG-TRTAEDIS 602
            :|.:|.|.::|:||||.::.|:|||:|||:|.|.|:||:.|.|.|.|.::|:||:. .|...:..
Zfish   454 STLVWLFSRLYVYSFIPVFTYMVLSVFIALITDTYETIRHYQKHGAPLSELQAFIADCRDPRNYD 518

  Fly   603 SGVFMTDLDDFDQTSFLDVVKSICC-CGRC 631
            ..   |..:|.:.:||       || |..|
Zfish   519 KN---TTNEDEESSSF-------CCLCAPC 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42638	NP_001163472.1	Ion_trans	403..578	CDD:278921	85/174 (49%)
mcoln3a	XP_021322333.1	PKD_channel	<358..491	CDD:332708	64/132 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592025
Domainoid	1	1.000	197	1.000	Domainoid score	I3054
eggNOG	1	0.900	-	-		E1_KOG3733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2003
OMA	1	1.010	-	-		QHG49191
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		otm25448
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	1	1.100	-	-	O	PTHR12127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3353
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790