DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42638 and mcoln3b

DIOPT Version :9

Sequence 1:	NP_001163472.1	Gene:	CG42638 / 8673965	FlyBaseID:	FBgn0261361	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_021325744.1	Gene:	mcoln3b / 100001113	ZFINID:	ZDB-GENE-080225-25	Length:	574	Species:	Danio rerio

Alignment Length:	578	Identity:	213/578 - (36%)
Similarity:	328/578 - (56%)	Gaps:	47/578 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 DGREE-----QPEFPGSSAASYQE---ERMRRKLQFFFMNPIEKWQAKRKFPYKFVVQIVKIFLV 130
            |.||:     .|....|...::.:   |..||||::|||||.:|::|:::.|:|..:|||||.:|
Zfish     3 DSREDYLCINDPNGNWSECEAHVDPALEAFRRKLKYFFMNPCDKYKARQRKPWKLFLQIVKIAVV 67

  Fly   131 TMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGWDSSREVESYPPAVGPFALYLKSEFFDTVQYAV 195
            |:||..|..|....:.:..:|...|.||||:.:..|.        ...:|:|.:.:.:..:.:.|
Zfish    68 TVQLVSFGLSNQMVVQFKEENLLTFRHLFLKNYSESN--------TNTYAIYTQLDVYTHITHIV 124

  Fly   196 NGYANV-SRSIGPYDYPTPNNTMPPLKLCLQNYREGTIFGFNESYIFDPHIDEVCERL-PPNVTT 258
            ..:..: |.::|.::|....:...||.:|.|.|..|:|...||::..|..:|:.|..: |.:..|
Zfish   125 QQFLMLPSITVGNHEYEQEGDVYTPLCICQQFYHNGSISPANETFDIDSRVDQECSLIYPQDPFT 189

  Fly   259 IGVENYLRQRDVEVNFASLVSAQLTFKIKTVNFKANGGPLSAPDCFRFDISITFNNRDHDGQMLL 323
            ....|:      .::|..|:|..:.|.:|.:|.:..... ..|||:.|:|.|.|:|:.|.|::|:
Zfish   190 ESPLNF------TLHFERLLSVTVNFTLKAINLETVEYH-ELPDCYVFNIMIQFDNKAHSGRILV 247

  Fly   324 SLDAEATRLKCHGATDF-ISDANFDSMLRSVL-NIFVLLTCALSFALCTRALWRAYLLRCTTVNF 386
            .||.|....:|   :|: ::.|:..:|...|| :..|:|..:.|..||.|::....||:.....|
Zfish   248 DLDNEVHIYEC---SDWSMTGASARNMYMMVLFDAVVILILSTSLLLCIRSVKAGVLLQKEYSEF 309

  Fly   387 FRSQFGKELSFDGRLEFVNFWYIMIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLL 451
            ...::.|.:|...||||:|.||::||.:|||.|.||.||..|:.:  .|..:|.||:.||.|.:|
Zfish   310 SLRRYRKCVSLSERLEFINGWYLLIIVSDVLTISGSVLKIVIQLK--AVASYDLCSILLGTGTML 372

  Fly   452 VWFGVLRYLGFFKTYN----------VVILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYH 506
            ||.|||||:|:.|.||          ::|:||:.|.|.::||...|.:||.|:.||||::|||||
Zfish   373 VWIGVLRYMGYLKKYNSMLCVCCVVQILIITLRVALPNVIRFTCCAAMIYLGYCFCGWIVLGPYH 437

  Fly   507 MKFRSLATTSECLFALINGDDMFATFATLSSKATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMD 571
            .|||:|.|.||.||:|||||||||||..:..|:..:|.|.::|||:|:||:||:||||||.:|.|
Zfish   438 TKFRTLNTVSESLFSLINGDDMFATFKNMQQKSFVVWLFSRLYLYTFVSLFIYMVLSLFITLITD 502

  Fly   572 AYDTIKAYYKDGFPTTDLKAFVGTRTAEDI-SSGVFMTDLDDFDQTSFLDVVKSICCC 628
            .|||||....||.|.:||:|||  ...:|: .||.|  .::..:..|.....|.:|||
Zfish   503 TYDTIKHQQLDGEPVSDLQAFV--LQCKDLPDSGEF--SVEKTNSISSTGGGKLMCCC 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42638	NP_001163472.1	Ion_trans	403..578	CDD:278921	97/184 (53%)
mcoln3b	XP_021325744.1	PKD_channel	<364..507	CDD:332708	76/142 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592027
Domainoid	1	1.000	197	1.000	Domainoid score	I3054
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10118
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2003
OMA	1	1.010	-	-		QHG49191
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		otm25448
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	1	1.100	-	-	LDO	PTHR12127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900