Protein Alignment EIF4G3 and TIF4631

DIOPT Version :10

• Sequence 1: XP_047289187.1
• Gene: EIF4G3 / 8672
• HGNCID: 3298
• Length: 1822
• Species: Homo sapiens
• Sequence 2: NP_011678.3
• Gene: TIF4631 / 853071
• SGDID: S000003394
• Length: 952
• Species: Saccharomyces cerevisiae
• Alignment Length: 1135
• Identity: 257/1135 - (22%)
• Similarity: 407/1135 - (35%)
• Gaps: 352/1135 - (31%)

Human   292 GPGPFYPGPGPGDFPNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDIT 356
            |.|.|..|....:..|...|.:|.:.|||.                         .|.|
Yeast    77 GGGSFRGGHMGANSSNVPWTGYYNNYPVYY-------------------------QPQQ------ 110

Human   357 EEIMSGGGSRNPTP-PIGRPTSTPTPPQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEE 420
               |:..||....| |:...:..||..::.::..||                      .|.|::.
Yeast   111 ---MAAAGSAPANPIPVEEKSPVPTKIEITTKSGEH----------------------LDLKEQH 150

Human   421 KPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTSS 485
            |.|                                               :.|..|||:
Yeast   151 KAK-----------------------------------------------LQSQERSTV------ 162

Human   486 ALSSQPIFTTAIDDRCELSSPREDTIPIPSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIPLV 550
              |.||            .|..::|      :..|.||.|.||...:|       |.|.::
Yeast   163 --SPQP------------ESKLKET------SDSTSTSTPTPTPSTND-------SKASSE---- 196

Human   551 SSTNLINEINGVSEKLSATESIVEIVKQEVLPLTLELEILENPPEEMKLE------CIPAPITPS 609
                     ..:||......:.:|.||       |....||...:| :||      .||...||.
Yeast   197 ---------ENISEAEKTRRNFIEQVK-------LRKAALEKKRKE-QLEGSSGNNNIPMKTTPE 244

Human   610 TVP---SFPP--TPPTPPA----SPPHTPVIVPA---------AATTVSSPSAAITVQRV-LEED 655
            .|.   |..|  |..|.||    :.|......||         .....|:|......:|: |::.
Yeast   245 NVEEKGSDKPEVTEKTKPAEEKSAEPEVKQETPAEEGEQGEKGQIKEESTPKVLTFAERLKLKKQ 309

Human   656 ESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAI----TVPKTWKKPKDRT 716
            :..|    |:..|.:...||....:|:..::|       :|||....:    .|.:|.:...|.:
Yeast   310 QKER----EEKTEGKENKEVPVQEETKSAIES-------APVPPSEQVKEETEVAETEQSNIDES 363

Human   717 RTTEEML----EAELELKAE-----EELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVEENGE 772
            .||..:.    |||.|::||     .::.::..:|:..|:...|         ...|..:....:
Yeast   364 ATTPAIPTKSDEAEAEVEAEAGDAGTKIGLEAEIETTTDETDDG---------TNTVSHILNVLK 419

Human   773 EAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPA 837
            :|.|:.: ..|.:..|||           :|....:|.|..|.|       |...|||.|:
Yeast   420 DATPIED-VFSFNYPEGI-----------EGPDIKYKKEHVKYT-------YGPTFLLQFK---- 461

Human   838 CIQKPEGLPPISDVVLDKIN---QPKLPMRTLDPRILPRGPDFTPAFAD---FGRQTPGG---RG 893
                            ||:|   ..:....|....::|.|........|   ||..:..|   |.
Yeast   462 ----------------DKLNVKADAEWVQSTASKIVIPPGMGRGNRSRDSGRFGNNSSRGHDFRN 510

Human   894 VPICKVQSRHGLPILEQSKAPTCPPLVMSHPPMKSLPLGLLNVGSRRS-QPGQRREPRKIITVSV 957
            ..:..:..|.......:.::..          |........:..|||. :.|..|...|......
Yeast   511 TSVRNMDDRANSRTSSKRRSKR----------MNDDRRSNRSYTSRRDRERGSYRNEEKREDDKP 565

Human   958 KEDV-HLKKAENAWKP------SQKRDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQ-- 1013
            ||:| .|..:.|.|.|      ::|:.:.....|.:...|:.||::|:|||||.:||:.:..:
Yeast   566 KEEVAPLVPSANRWVPKFKSKKTEKKLAPDGKTELLDKDEVERKMKSLLNKLTLEMFDAISSEIL 630

Human  1014 -VSGLTV-DTE-ERLKGVIDLVFEKAIDEPSFSVAYANMC-RCLVTLKVPMADKPGNTVNFRKLL 1074
             ::.::| :|. |.||.||:.:|.||.|||.:|..||.:| :.:..|...:.|:........||:
Yeast   631 AIANISVWETNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKVVKELNPDITDETNEGKTGPKLV 695

Human  1075 LN----RCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDEL--EE--AKDKARRRSIGNIK 1131
            |:    ||..||:|...|            .....|:.|.|..|:  ||  |...|:||.:|.::
Yeast   696 LHYLVARCHAEFDKGWTD------------KLPTNEDGTPLEPEMMSEEYYAAASAKRRGLGLVR 748

Human  1132 FIGELFKLKMLTEAIMHDCVVKLLK----NHDEESLECLCRLLTTIGKDLDFE---------KAK 1183
            |||.|::|.:||..:|.:|..:|:|    :..||:||.:..||.|:|:..:.:         :..
Yeast   749 FIGFLYRLNLLTGKMMFECFRRLMKDLTDSPSEETLESVVELLNTVGEQFETDSFRTGQATLEGS 813

Human  1184 PRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRL-CNWVSRRADQGPKTIEQIHKEAKIEEQEE 1247
            ..:|..|..::.|::..|.||||:|.|.|:.:||. .||.|.:.|.|||||:|||     ||:|.
Yeast   814 QLLDSLFGILDNIIQTAKISSRIKFKLIDIKELRHDKNWNSDKKDNGPKTIQQIH-----EEEER 873

Human  1248 QRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDP-SKFLKITKPTIDEKIQLVPKAQLGS 1311
            ||:::.......||..         |:.......|...| ||...||..|..::
Yeast   874 QRQLKNNSRSNSRRTN---------NSSNRHSFRRDAPPASKDSFITTRTYSQR----------- 918

Human  1312 WGKGSSGGAKASETDALRSSASSLNRFSAL 1341
                :|..|...:.:....::::.|.||||
Yeast   919 ----NSQRAPPPKEEPAAPTSTATNMFSAL 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4G3	XP_047289187.1	PHA03378	<74..492	CDD:223065	31/200 (16%)
		MIF4G	992..1220	CDD:397130	81/255 (32%)
		MA3	1459..1571	CDD:397128
		W2_eIF4G1_like	1665..1793	CDD:211397
		W2	<1772..1818	CDD:473053
TIF4631	NP_011678.3	PTZ00121	<133..362	CDD:173412	65/362 (18%)
		eIF_4G1	411..469	CDD:432365	20/96 (21%)
		SF-CC1	489..>562	CDD:273721	13/82 (16%)
		MIF4G	607..850	CDD:397130	81/254 (32%)