Protein Alignment EIF4G3 and TIF4632

DIOPT Version :10

• Sequence 1: XP_047289187.1
• Gene: EIF4G3 / 8672
• HGNCID: 3298
• Length: 1822
• Species: Homo sapiens
• Sequence 2: NP_011466.1
• Gene: TIF4632 / 852833
• SGDID: S000003017
• Length: 914
• Species: Saccharomyces cerevisiae
• Alignment Length: 1151
• Identity: 258/1151 - (22%)
• Similarity: 416/1151 - (36%)
• Gaps: 340/1151 - (29%)

Human   281 GPPQQYPVQPPGPGPF------YPGPGPGDFPNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKRE 339
            |||..:|.|..|...|      |.|.......|.|....|.::..:.:      .|.|....|..
Yeast     6 GPPPPHPQQANGYKKFPPHDNQYSGANNSQPNNHYNENLYSAREPHNN------KQYQSKNGKYG 64

Human   340 KKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQLPS-QVPE--HSPVVYGTVES 401
            ......|:.:||.........:.|...|        .:...|..||. |.|.  ::|.:|...:.
Yeast    65 TNKYNNRNNSQGNAQYYNNRFNNGYRLN--------NNDYNPAMLPGMQWPANYYAPQMYYIPQQ 121

Human   402 AHLAASTPVTAASDQKQEEKPKPDPVLKSPSPVL------RLVL----------SGEKKEQ--EG 448
            ....||.|.|   .|.....|:|....|:....:      ||.|          .||:|..  |.
Yeast   122 MVPVASPPYT---HQPLNTNPEPPSTPKTTKIEITTKTGERLNLKKFHEEKKASKGEEKNDGVEQ 183

Human   449 QTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTSSALSSQPIFTTAIDDRCELSSPREDTIPI 513
            ::...|.....|...||.:.....::..::....||.|.:::.:|...:..|......:::.:
Yeast   184 KSKSGTPFEKEATPVLPANEAVKDTLTETSNEKSTSEAENTKRLFLEQVRLRKAAMERKKNGL-- 246

Human   514 PSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEINGVSEKLSATESIVEIVKQ 578
                 .:||.....|:.:|:....||.||
Yeast   247 -----ISETEKKQETSNHDNTDTTKPNSV------------------------------------ 270

Human   579 EVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPASPPHTPVIVPAAATTVSSP- 642
                  :|.|.::..|:                          |....:..||...:..:|.:|
Yeast   271 ------IESEPIKEAPK--------------------------PTGEANEVVIDGKSGASVKTPQ 303

Human   643 --SAAITVQRVLEEDESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAITV 705
              :.::|......|.|:..:  |:|..|:..      |..|.||.|:                |.
Yeast   304 HVTGSVTKSVTFNEPENESS--SQDVDELVK------DDDTTEISDT----------------TG 344

Human   706 PKTWKKPKDRTRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPS----DLKKVKA 766
            .||..|..|.|                    |:.|:.:|::.:.     |.:||    ::..|..
Yeast   345 GKTVNKSDDET--------------------INSVITTEENTVK-----ETEPSTSDIEMPTVSQ 384

Human   767 VEENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKK-----QYDR 826
            :.|...:|:|:                       .|...|.: ||:.:..|.:.||     .|..
Yeast   385 LLETLGKAQPI-----------------------SDIYEFAY-PENVERPDIKYKKPSVKYTYGP 425

Human   827 EFLLDF----QFMPACIQKPEGLPPISDVVLDKINQPKLPMRTLDPRILPRGPDFTPAF-ADFGR 886
            .|||.|    :|.|.        |...:.|..||        .:.|.|....|..:..| .||
Yeast   426 TFLLQFKDKLKFRPD--------PAWVEAVSSKI--------VIPPHIARNKPKDSGRFGGDF-- 472

Human   887 QTPGGRGV---PICKVQSRHGLPILEQSKAPTCPPLVMSHPPMKSLPLGLLNVGSRRSQPG---- 944
            ::|..||:   ...:|.|:.                       :|..:|    ..|||..|
Yeast   473 RSPSMRGMDHTSSSRVSSKR-----------------------RSKRMG----DDRRSNRGYTSR 510

Human   945 --QRREPRKIITVSVKEDV-HLKKAENAW------KPSQKRDSQADDPENIKTQELFRKVRSILN 1000
              :.:...|....:.||:: .|..:.|.|      |.::|:.:.....|....:|:.||::|:||
Yeast   511 KDREKAAEKAEEQAPKEEIAPLVPSANRWIPKSRVKKTEKKLAPDGKTELFDKEEVERKMKSLLN 575

Human  1001 KLTPQMFNQLMKQVSGLT-----VDTEERLKGVIDLVFEKAIDEPSFSVAYANMC-RCLVTLKVP 1059
            |||.:||:.:..::..:.     .|..|.||.||:.:|.||.|||.:|..||.:| :.:..|...
Yeast   576 KLTLEMFDSISSEILDIANQSKWEDDGETLKIVIEQIFHKACDEPHWSSMYAQLCGKVVKDLDPN 640

Human  1060 MADKPGNTVNFRKLLLN----RCQKEFEKDKADDDVFEKKQKELEAA--SAPEERTRLHDELEEA 1118
            :.||.....|..||:|:    ||.:||||..||         :|.|.  ..|.|...:.||...|
Yeast   641 IKDKENEGKNGPKLVLHYLVARCHEEFEKGWAD---------KLPAGEDGNPLEPEMMSDEYYIA 696

Human  1119 KDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLK--NHD--EESLECLCRLLTTIGKDLDF 1179
            . .|:||.:|.::|||.|:.|.:||..:|.:|..:|:|  |:|  ||:||.:..||.|:|:..:.
Yeast   697 A-AAKRRGLGLVRFIGYLYCLNLLTGKMMFECFRRLMKDLNNDPSEETLESVIELLNTVGEQFEH 760

Human  1180 EK-AKPR--------MDQYFNQMEKIVKERKTSSRIRFMLQDVIDLR-LCNWVSRRADQGPKTIE 1234
            :| ..|:        :|..|..::.|:.....|:||:|.|.||.:|| :.:|.|.:.|.|||||:
Yeast   761 DKFVTPQATLEGSVLLDNLFMLLQHIIDGGTISNRIKFKLIDVKELREIKHWNSAKKDAGPKTIQ 825

Human  1235 QIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDE 1299
            |||:|   |||..|:|..|       |...:..:....|:.:.:.|.|.:.
Yeast   826 QIHQE---EEQLRQKKNSQ-------RSNSRFNNHNQSNSNRYSSNRRNMQ-------------- 866

Human  1300 KIQLVPKAQLGSWGKGSSGGAKASETDALR----SSASSLNRFSAL 1341
                  ..|..|:....:|..:.::.:|.:    |.|...|.|.||
Yeast   867 ------NTQRDSFASTKTGSFRNNQRNARKVEEVSQAPRANMFDAL 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4G3	XP_047289187.1	PHA03378	<74..492	CDD:223065	49/237 (21%)
		MIF4G	992..1220	CDD:397130	87/253 (34%)
		MA3	1459..1571	CDD:397128
		W2_eIF4G1_like	1665..1793	CDD:211397
		W2	<1772..1818	CDD:473053
TIF4632	NP_011466.1	eIF_4G1	381..440	CDD:432365	17/82 (21%)
		MIF4G	567..808	CDD:397130	86/250 (34%)