Protein Alignment EIF4G3 and Eif4g3

DIOPT Version :10

• Sequence 1: XP_047289187.1
• Gene: EIF4G3 / 8672
• HGNCID: 3298
• Length: 1822
• Species: Homo sapiens
• Sequence 2: XP_006538839.1
• Gene: Eif4g3 / 230861
• MGIID: 1923935
• Length: 1773
• Species: Mus musculus
• Alignment Length: 1824
• Identity: 1551/1824 - (85%)
• Similarity: 1632/1824 - (89%)
• Gaps: 53/1824 - (2%)

Human     1 MSLPQKPALKSGTATAAGTGPGTGAAAAAAAAVPPPHPAAAAAAAAAAAAAAAAAVPPPHPNIRA 65
            ||||||||||||:|.|||||||||  ||||||||||||||||||||.|||||     ||||||||
Mouse     1 MSLPQKPALKSGSAAAAGTGPGTG--AAAAAAVPPPHPAAAAAAAAVAAAAA-----PPHPNIRA 58

Human    66 LQTQAPQQIPRGPVQQPLEDRIFTPAVSAVYSTVTQVARQPGTPTPSPYSAHEINKGHPNLAATP 130
            |||.|||||||||||||||||:|.|.||||||||||||||||.|||:|||||||:||.|:|||||
Mouse    59 LQTPAPQQIPRGPVQQPLEDRLFPPTVSAVYSTVTQVARQPGPPTPAPYSAHEISKGLPSLAATP 123

Human   131 PGHASSPGLSQTPYPSGQNAGPTTLVYPQTPQTMNSQPQTRSPPSRTVPIHCTDNWKRRKVLEQT 195
            ||||||||||||||||||||||.||||||.|||||||||.||||.|||||||||..||||||||:
Mouse   124 PGHASSPGLSQTPYPSGQNAGPATLVYPQAPQTMNSQPQARSPPGRTVPIHCTDTRKRRKVLEQS 188

Human   196 PVYRSLAGRGWIKYCIFFQRPQIQPPRATIPNSSPSIRPGAQTPTAVYQANQHIMMVNHLPMPYP 260
            ||||||||||||||.|||||||||||||.|||||||||||.||||||||||||||||||||||||
Mouse   189 PVYRSLAGRGWIKYYIFFQRPQIQPPRAAIPNSSPSIRPGVQTPTAVYQANQHIMMVNHLPMPYP 253

Human   261 VPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFPNAYGTPFYPSQPVYQSAPI 325
            |.||.||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||
Mouse   254 VTQGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPI 318

Human   326 IVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPP-QLPSQVP 389
            ||||||||||||||||||||||||||||||||||||||||||||||||||.|||||| |||||||
Mouse   319 IVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVP 383

Human   390 EHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETT 454
            ||||||||||||||||||||||||||||||||||||||.:|||.|||||||||||||.||..||.
Mouse   384 EHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPETA 448

Human   455 AIVSIAELPLPPSPTTVSSVARSTIAAPTSSALSSQPIFTTAIDDRCEL-SSPREDTIPIPSLTS 518
            |.....|.|...|||::..:|||::.:|.|:||||||:||.  :|:||| ||..||..|:||.||
Mouse   449 AGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTA--EDKCELPSSKEEDAPPVPSPTS 511

Human   519 CTETSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEINGVSEKLSATESIVEIVKQEVLPL 583
            ||..|.|..|  ::.|||||||||||:|..|:|||.||||:|||.|||||.|:.|.:::||||||
Mouse   512 CTAASGPSLT--DNSDICKKPCSVAPHDSQLISSTILINEMNGVGEKLSAKENTVGMLRQEVLPL 574

Human   584 TLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPASPPHTPVIVPAAATTVSSPSAAITV 648
            ||||||||:|.||:|:||.|.||.||.:|:|.|.|||||.|||..||::.||  ...||:.|..|
Mouse   575 TLELEILEHPQEELKVECTPTPIAPSMLPAFSPAPPTPPTSPPCPPVVLSAA--IARSPAVATEV 637

Human   649 QRVLEEDESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAITVPKTWKKPK 713
            |||.:|.||:|||||:||||:|:|.|.|:|||.||..|.|:|:|.|||.|.|.|.|.||:|||.|
Mouse   638 QRVADEGESLRTCLSKDAKEMQDKAESESDGQAEETADPQSLHSGRSPAPVQTATTAPKSWKKTK 702

Human   714 DRTRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVEENGEEAEPVR 778
            ::|||.:|:||||.|.||||||::|.|||.||:||||||..|||||.||:.||.|.|||||||||
Mouse   703 EQTRTPDEVLEAEAEPKAEEELAVDSVLEPEQEKMSQGFPSERDPSALKRGKAEEGNGEEAEPVR 767

Human   779 NGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPACIQKPE 843
            |||||.|||||.|.||||.|||.||:|||||.|||||.|||||||||||||||.|||||||||||
Mouse   768 NGAESASEGEGGDGNSGSADSSADGLTFPFKAESWKPADTEGKKQYDREFLLDIQFMPACIQKPE 832

Human   844 GLPPISDVVLDKINQPKLPMRTLDPRILPRGPDFTPAFADFGRQTPGGRGVPICKVQSRHGLPIL 908
            ||||||||||||||||:|.||||||||||||||||||||||.||||||||||
Mouse   833 GLPPISDVVLDKINQPRLSMRTLDPRILPRGPDFTPAFADFPRQTPGGRGVP------------- 884

Human   909 EQSKAPTCPPLVMSHPPMKSLPLGLLNVGSRRSQPGQRREPRKIITVSVKEDVHLKKAENAWKPS 973
                                    |||||.|||||||||||||||||||||||||:|||||||||
Mouse   885 ------------------------LLNVGPRRSQPGQRREPRKIITVSVKEDVHLRKAENAWKPS 925

Human   974 QKRDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDTEERLKGVIDLVFEKAID 1038
            |||||.|||||:||||||||||||||||||||||||||||||.||||||||||||||||||||||
Mouse   926 QKRDSHADDPESIKTQELFRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAID 990

Human  1039 EPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAAS 1103
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   991 EPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAAS 1055

Human  1104 APEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCR 1168
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1056 APEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCR 1120

Human  1169 LLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTI 1233
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1121 LLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTI 1185

Human  1234 EQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTID 1298
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1186 EQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTID 1250

Human  1299 EKIQLVPKAQLGSWGKGSSGGAKASETDALRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTL 1363
            ||||||||||||||||||||||||||:||||||||||||||.|||||||||..:||:||||||.|
Mouse  1251 EKIQLVPKAQLGSWGKGSSGGAKASESDALRSSASSLNRFSPLQPPAPSGSPSATPLEFDSRRAL 1315

Human  1364 TSRGSMGREKNDKPLPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNST 1428
            ||||||||||:|||:|:.|||||||:| |||||||||||||||||||||||||||||:|.||.||
Mouse  1316 TSRGSMGREKSDKPIPAGTARPNTFLR-GSSKDLLDNQSQEEQRREMLETVKQLTGGLDAERAST 1379

Human  1429 EAERNKTRESAKPEISAMSAHDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLH 1493
            ||:|:||||.||.|:.|:.|.||.||||||:||||||||||||||||||||.||:|||:|||.||
Mouse  1380 EADRSKTRELAKSEMCAVPAPDKPALSEEEVERKSKSIIDEFLHINDFKEATQCIEELSAQGPLH 1444

Human  1494 VFVRVGVESTLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLA 1558
            |||:||||.|||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mouse  1445 VFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLA 1509

Human  1559 ELVTPMLKEGGISMRELTIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALWREADLSWKDF 1623
            ||||||||.||||||||.:||||||||||||||||||||||||:|||||||||||||||||||||
Mouse  1510 ELVTPMLKGGGISMRELIVEFSKPLLPVGRAGVLLSEILHLLCRQMSHKKVGALWREADLSWKDF 1574

Human  1624 LPEGEDVHNFLLEQKLDFIESDSPCSSEALSKKELSAEELYKRLEKLIIEDKANDEQIFDWVEAN 1688
            ||||||||:|||||||||.||:.|||||||||||||||||.:||||||:|:||:||:||||||||
Mouse  1575 LPEGEDVHHFLLEQKLDFTESEGPCSSEALSKKELSAEELSQRLEKLIMEEKADDERIFDWVEAN 1639

Human  1689 LDEIQMSSPTFLRALMTAVCKAAIIADSSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQA 1753
            |||.|||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
Mouse  1640 LDESQMSSPTFLRALMTAVCKAAIIADCSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQA 1704

Human  1754 SIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQNGKGVALKSVTAFFTWLREAEEE 1818
            ||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||
Mouse  1705 SIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQAGKGVALKSVTAFFTWLREAEEE 1769

Human  1819 SEDN 1822
            ||||
Mouse  1770 SEDN 1773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4G3	XP_047289187.1	PHA03378	<74..492	CDD:223065	368/418 (88%)
		MIF4G	992..1220	CDD:397130	226/227 (100%)
		MA3	1459..1571	CDD:397128	102/111 (92%)
		W2_eIF4G1_like	1665..1793	CDD:211397	120/127 (94%)
		W2	<1772..1818	CDD:473053	44/45 (98%)
Eif4g3	XP_006538839.1	PHA03247	<57..472	CDD:223021	369/414 (89%)
		MIF4G	944..1172	CDD:397130	226/227 (100%)
		MA3	1410..1522	CDD:397128	102/111 (92%)
		W2_eIF4G1_like	1612..1744	CDD:211397	123/131 (94%)
		W2	<1723..1769	CDD:473053	44/45 (98%)