Protein Alignment EIF4G3 and ifg-1

DIOPT Version :10

• Sequence 1: XP_047289187.1
• Gene: EIF4G3 / 8672
• HGNCID: 3298
• Length: 1822
• Species: Homo sapiens
• Sequence 2: NP_001368728.1
• Gene: ifg-1 / 174322
• WormBaseID: WBGene00002066
• Length: 1160
• Species: Caenorhabditis elegans
• Alignment Length: 1626
• Identity: 337/1626 - (20%)
• Similarity: 559/1626 - (34%)
• Gaps: 593/1626 - (36%)

Human   102 VARQPGTPTPSPYSAHEINKG-HPNLAATPPGHASSPGLSQTPYPSGQNAGPTTLVYPQTPQTMN 165
            |:|.||...|        |:| |.:..|.|...:|    .|...|....:||....|.:.|...:
 Worm     5 VSRGPGRGKP--------NQGFHSDHNAVPMQDSS----QQFVMPFVNTSGPVNSNYQRMPMNQS 57

Human   166 SQPQTRSPPSRTVPIHCTDNWKRRKVLEQTPVYRSLAGRGWIKYCIFFQRPQIQPPRATIPNSSP 230
            :.||                                          :.|:...||
 Worm    58 AYPQ------------------------------------------YGQQQYNQP---------- 70

Human   231 SIRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSG---PPYVGPPQQYPVQPPG 292
                  ||              ||.   || ||.||:   |.::.|   |.|...||.|..|..|
 Worm    71 ------QT--------------NHY---YP-PQAPQH---QQQYGGYQRPDYGHQPQMYNQQYQG 108

Human   293 ---PGPFYPGPGPGDFPNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKD 354
               |..::|           ..|:.|:||..|..     |...|...||::|.:.|.||.
 Worm   109 YQAPQQYHP-----------EMPYQPAQPAQQQM-----THTAPQEPKRQRKALEIVDPT----- 152

Human   355 ITEEIMSGGGSRNPTPPIGRPTSTPTPPQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQE 419
             |::.:                             |.:|         |||.:.|..||
 Worm   153 -TKKAI-----------------------------EVTP---------HLAPAAPAPAA------ 172

Human   420 EKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTS 484
                         |...:....|||:|.                     .|:.
 Worm   173 -------------PAAPIAPEEEKKKQN---------------------ITLE------------ 191

Human   485 SALSSQPIFTTAIDDRCELSSPREDTIP-IPSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIP 548
                    |...:.:.......|.|..| :|:.......:..||.           .||.|   |
 Worm   192 --------FLNQVKNELHHEDRRHDNPPAVPAAVPAAVQAAVLPN-----------FSVPP---P 234

Human   549 LVSSTNLINEINGVSEKLSATESIVEIVKQEVLPLTLELEILENPPEEMKLECIPAPITPSTVPS 613
            .:..|                                       ||        .|.|.|..|||
 Worm   235 ALGQT---------------------------------------PP--------AASIAPQVVPS 252

Human   614 FPPTPPTP---------------PASPPH---TPVIVPAAATTVSSPSAA-ITVQRVLEEDESIR 659
            .|.||..|               |.|.||   |....||:.|..|:.:.| :.|...|.::||
 Worm   253 VPKTPEAPAKADYEVKQAETLVTPVSSPHASDTTTTTPASGTAESASTVADVRVTPTLTKEES-- 315

Human   660 TCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAITVPKTWKKPKDRTRTTEEMLE 724
                        |.|.: |.:.||                             .|...:|.::.:
 Worm   316 ------------KEETD-DDKFEE-----------------------------NDERESTPDVAD 338

Human   725 AELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVEENGEE--AEPVRNGAESVSEG 787
            :..| |..|||.|:|.              :::..:::|.|..||..|:  .|.:..|:..:|:|
 Worm   339 SSTE-KTPEELEIEKA--------------QKEAEEIEKKKLREEALEKRIEELILAGSAVISDG 388

Human   788 EGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPACIQK-PEGLPP--IS 849
                                               .:.|:|::..:.:.....: |..|.|  ::
 Worm   389 -----------------------------------TFGRDFMVTIREIEKVFSRTPCPLSPAQLA 418

Human   850 DVVLDKINQPKLPMRTLDPRILPRGPDFTPAFADFG--RQTPGGRGVPICKVQSRHGLPILEQSK 912
            |..||     ...||..|    .:.|:|||.:|:.|  ||....||........|.|
 Worm   419 DFGLD-----IKTMRVSD----NKKPNFTPNWANKGGNRQQVPYRGRTTTDGTGRGG-------- 466

Human   913 APTCPPLVMSHPPMKSLPLGLLNVGSRRSQPGQRREPRKIITVSVK--EDVHLKKAENAWKPSQK 975
                                    ..:|.:...:|.|  ::..|::  :.|.|..:::||||.::
 Worm   467 ------------------------QQQRDRMHNKRPP--VVRPSIERVQRVTLPSSKDAWKPDRQ 505

Human   976 RDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDTEE-RLKGVIDLVFEKAIDE 1039
            :.::|...|.....|:.:||||::||:||.....|.::.....|.:.: :|..|:::||:||::|
 Worm   506 KTAEAVASEEAAVIEVCKKVRSLMNKVTPTSQRPLTEEFISYNVSSNDAQLAQVVEIVFDKAVEE 570

Human  1040 PSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDD-----VFEKKQ--- 1096
            |.|...||.||:.....::   .:.|....||..:|.|.|..|: ||.|.|     :.||::
 Worm   571 PKFCALYAEMCKAQANHEL---SQTGGKSAFRNKVLTRTQMTFQ-DKKDIDADKLAIIEKEEDPV 631

Human  1097 -KELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLL----- 1155
             |||              .|.|.|.|.|||..|.:.|:|.|::.::|:..|:..|..:|.
 Worm   632 KKEL--------------MLAEEKQKFRRRKFGVMTFMGYLYRNQLLSTKIVQTCTFELFNSIKD 682

Human  1156 -----KNHDEESLECLCRLLTTIGKDLDFEKAKPR--MDQYFNQMEKIVKERKTSSRIRFMLQDV 1213
                 ::.||||:.|..:|:.|:|..||..|....  :||:|.::|  ..:...|::||||:.::
 Worm   683 QDIKKEDVDEESIHCGLQLIETVGVMLDKSKDSTTVFLDQWFQKLE--AAKPYCSNKIRFMIMNL 745

Human  1214 IDLRLCNWVSRRA-DQGPKTIEQIHKEAKIEE-QEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQ 1276
            ::||...|:.|:: :.|||.|::|||:.:.|: :.|:.:.|....:::|..||:........:|.
 Worm   746 MELRKDKWIPRKSTESGPKKIDEIHKDIRQEKIENEKARDQYDRDRDRRHGGVRPNSNSLRKSVP 810

Human  1277 GAKNSRVLDPSKFL--------------KITKPTIDEK---IQLVPKAQLG----SWGKGSSGGA 1320
            .::||  ||.::.:              |:...::..|   :..:....||    .|..|:|||.
 Worm   811 VSRNS--LDRNRGMQHPEQKRAAAAANTKLASSSVQPKNISLSSMDNNTLGKSKKEWHSGASGGG 873

Human  1321 KASETDALRSSASSLNRFSALQPPAPS--GSTPSTPVEFDSRRTLTSRGSMGREKNDKPLPSATA 1383
            ..|...|:               |..|  |...|.    |.|:..|        .::|....|.|
 Worm   874 NTSSESAV---------------PVKSAWGRRDSN----DQRKKST--------VDEKQAALAAA 911

Human  1384 RPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNSTEAERNKTRESAKPEISAMSA 1448
            :..:.|...|.:....|.:.::...|:.|..|              |.|.|...:.|.::..||:
 Worm   912 KEISAMSISSRRSTSQNSNTDKTDDELTEEEK--------------AVRAKIMNTVKSDLLEMSS 962

Human  1449 HDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLHVFVRVGVESTLERSQITRDH 1513
            .:   ||::||       :|.   |.|:...    |:..:..|..|:..: :.:.:|:. :..|.
 Worm   963 GE---LSQKEL-------VDS---ITDYVGK----EKYGSPSLTVVYEMI-IRAVIEKG-LKDDD 1008

Human  1514 MGQLLYQLVQS--EKLSKQDFFKGFSETLELADDMAI--DIPHIWLYLAELV-----TPMLKEGG 1569
            ..:|...|..|  .|..||.|.:|.:...:.|:|:.:  |.|.:|....|::     .|..:.|
 Worm  1009 RKKLAIALRMSLVSKTEKQAFIEGATRFCKFANDVELQQDYPKLWTVTGEVLVNTSHAPHDEIG- 1072

Human  1570 ISMRELTIEFSKPLLPVGRA-GVLLSEILHLLCKQMSHKKV-------GALWREADLSWKDFLPE 1626
             .:...::...||:....:. |....::|..:.||:...::       |..|..:|:..|..:.|
 Worm  1073 -EVESFSLADMKPIFSAAKGEGNKKFDLLVQVLKQLIELELEVTGAAEGISWEFSDMKLKTEMEE 1136

Human  1627 G 1627
            |
 Worm  1137 G 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4G3	XP_047289187.1	PHA03378	<74..492	CDD:223065	71/396 (18%)
		MIF4G	992..1220	CDD:397130	76/249 (31%)
		MA3	1459..1571	CDD:397128	25/120 (21%)
		W2_eIF4G1_like	1665..1793	CDD:211397
		W2	<1772..1818	CDD:473053
ifg-1	NP_001368728.1	Atrophin-1	<226..>334	CDD:460830	39/212 (18%)
		MIF4G	522..752	CDD:397130	76/249 (31%)