Protein Alignment EIF4G3 and eif4g3

DIOPT Version :10

• Sequence 1: XP_047289187.1
• Gene: EIF4G3 / 8672
• HGNCID: 3298
• Length: 1822
• Species: Homo sapiens
• Sequence 2: XP_031760741.1
• Gene: eif4g3 / 100216088
• XenbaseID: XB-GENE-1010293
• Length: 1740
• Species: Xenopus tropicalis
• Alignment Length: 1880
• Identity: 1219/1880 - (64%)
• Similarity: 1364/1880 - (72%)
• Gaps: 198/1880 - (10%)

Human     1 MSLPQKPALKSGTATAAGTGPGTGAAAAAAAAVPPPHPAAAAAAAAAAAAAAAAAVPPPHPNIRA 65
            ||||||.|||    .||.||.|       |..|.|| |:||..|||.:|             |||
 Frog     1 MSLPQKAALK----PAAPTGTG-------ALVVGPP-PSAAPPAAAPSA-------------IRA 40

Human    66 LQTQAPQQIPRGPVQQPLEDRIFTP-AVSAVYSTV-TQVARQPGTPTPSPYSAHEINKGHPNLAA 128
            |  |.|.||.||.:||.|::|||:| ||||||||| .|||||||.|.|||||.|:::||||||||
 Frog    41 L--QPPPQISRGALQQSLDERIFSPSAVSAVYSTVAAQVARQPGPPAPSPYSTHDLSKGHPNLAA 103

Human   129 TPPGHASSPGLSQTPYPSGQNAGPTTLVYPQTPQTMNSQPQTRSP-PSRTVPIHCTDNWKRRKVL 192
            ||||||:||||||..|.|||:....||||||.||||::|||.||| .:...|.|
 Frog   104 TPPGHAASPGLSQASYASGQSPAAPTLVYPQPPQTMSTQPQNRSPFAAGPRPAH----------- 157

Human   193 EQTPVYRSLAGRGWIKYCIFFQRPQIQPPRATIPNSSPSIRPGAQTPTAVYQANQHIMMVNHLPM 257
                      .:|..:...||||.|||||||.|..||||||.||||||||||.||||||||||||
 Frog   158 ----------HQGGFRPIQFFQRTQIQPPRAAIQTSSPSIRAGAQTPTAVYQTNQHIMMVNHLPM 212

Human   258 PYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFPNAYGTPFYPSQPVYQS 322
            ||.:||||||||||||||.|||||||||||||||||.||||||||||||..||.|||.|||||||
 Frog   213 PYAMPQGPQYCIPQYRHSAPPYVGPPQQYPVQPPGPSPFYPGPGPGDFPTPYGAPFYSSQPVYQS 277

Human   323 APIIVPTQQQ---PPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPP-Q 383
            ||||||||||   |||||||||.||||||||||||||||||||.||||.||||.||.|||||| |
 Frog   278 APIIVPTQQQQQPPPPAKREKKPIRIRDPNQGGKDITEEIMSGVGSRNSTPPILRPNSTPTPPQQ 342

Human   384 LPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVLK-SPSPVLRLVLSGEKKEQE 447
            ||||.|||.||||||:||.||.|:.|....|:.|.||||||:..:| :|.|.:|      ....:
 Frog   343 LPSQAPEHGPVVYGTMESPHLPATFPAAPVSEPKPEEKPKPEHTVKATPPPCVR------PDPVD 401

Human   448 GQTSETTAIVSIAELPLPPS-------PTTVSSVARSTIA---APTSSALSSQPIFTTAIDDRCE 502
            ..||:.     |.:.|.|.|       |..:..|..:.|.   .||:.|      |...:||...
 Frog   402 IGTSDV-----IEQTPRPASSERPELQPCLLPGVTAAPIVVPIVPTAQA------FPCHLDDTRG 455

Human   503 LSSPREDTIPIPSLTSCTETSDPLPTNENDDDICKKPC-SVAPNDIPLVSSTNLINEINGVSEKL 566
            ..||.|...|.|   |..:.|||.   |.::.:||.|. .|||.|.||.:|.....|:||:.:.:
 Frog   456 SESPAEVRAPTP---STPQESDPA---ETEEVVCKDPVGQVAPADAPLPASALPAQEMNGLGDDM 514

Human   567 SAT--------ESIVEIVKQEVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPA 623
            :.|        .::.|:...||..|.        .|.:...||..:...|.:.|:...:|  .|.
 Frog   515 AGTAAGAAGEESALAEVDLPEVPGLA--------APMDADAECTTSSNVPLSSPALSASP--LPD 569

Human   624 SPPHTPVIVPAAATTVSSPSAAIT---VQRVLEEDESIRTCLSEDAKEIQNKIEVEADGQTEEIL 685
            |||      |..|.::|.|::|:.   .|.|.|:::.....|..|. |.|.|...|.|.:.|..:
 Frog   570 SPP------PLIAASLSPPASALATLCAQDVAEQEDGRAATLESDG-EGQGKGRTEGDSELESSV 627

Human   686 DSQNLNSRRSPVPAQIAITVPKTWKKPKDRTRTTEEMLEAELELKAEEELSIDKVLESEQDKM-- 748
            ...::||::|||.|..|||.||.|:||||.:...||:.::|.|.:.|::...|||.|.:||.:
 Frog   628 KLLSINSKKSPVEAPAAITAPKMWQKPKDESPDIEEISQSETEPQYEDDPLEDKVTELDQDPVTY 692

Human   749 SQGFHPERDPSDLKKVKAVEENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPF----- 808
            |.....|.:...|...|..|:|| |.||:||||::|||.||.|..||:.    :|:.:|:
 Frog   693 SGTSTMEVEQLYLNNAKPQEQNG-EVEPIRNGADAVSESEGTDIPSGTE----EGLAYPYSKAGI 752

Human   809 -----------KPESWKPTDTEGKKQYDREFLLDFQFMPACIQKPEGLPPISDVVLDKINQPKLP 862
                       :|.: .|...:||:||||:|||.||:||||:|||||||||||||||||||||||
 Frog   753 GAAEQPPDPSQEPPA-PPQSADGKRQYDRDFLLGFQYMPACVQKPEGLPPISDVVLDKINQPKLP 816

Human   863 MRTLDPRILPRGPDFTPAFADFGRQTPGGRGVPICKVQSRHGLPILEQSKAPTCPPLVMSHPPMK 927
            :|.||.|:|.||||||||:|||||..|||||:|
 Frog   817 IRALDARMLQRGPDFTPAYADFGRPAPGGRGMP-------------------------------- 849

Human   928 SLPLGLLNVGSRRSQPGQRREPRKII-TVSVKEDVHLKKAENAWKPSQKRDSQADDPENIKTQEL 991
                 ||:||.||||||||||||||| .:||.:||||||:|||||||.||||..:||::|:||.|
 Frog   850 -----LLSVGPRRSQPGQRREPRKIIMNISVSDDVHLKKSENAWKPSVKRDSLPEDPDSIRTQAL 909

Human   992 FRKVRSILNKLTPQMFNQLMKQVSGLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTL 1056
            |||||||||||||||||||||||:.|||||||||||||||||||||||||||||||||||||.||
 Frog   910 FRKVRSILNKLTPQMFNQLMKQVTDLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLATL 974

Human  1057 KVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAKDK 1121
            |||||||||:|||||||||||||||||||||||||||||||:||.|:.|||::||.|||||:|||
 Frog   975 KVPMADKPGSTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKDLELATTPEEKSRLQDELEESKDK 1039

Human  1122 ARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRM 1186
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1040 ARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRM 1104

Human  1187 DQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKV 1251
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
 Frog  1105 DQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLSNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKV 1169

Human  1252 QQLMTKEKRRP-GVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQLVPKAQLGSWGKG 1315
            ||||||||||| ||||||||||||||||||:|||||||||||||||||||||||||||.|||.||
 Frog  1170 QQLMTKEKRRPAGVQRVDEGGWNTVQGAKNNRVLDPSKFLKITKPTIDEKIQLVPKAQPGSWLKG 1234

Human  1316 SSGGAKASETDALRSSASSLNRFSALQPP--APSGSTPSTPVEFDSRRTLT-SRGSMGREKNDKP 1377
            ||||||||||::||..|.|||||||||.|  :.|.|:.|:|.|.||||.|| ||||.||||||||
 Frog  1235 SSGGAKASETESLRPGAPSLNRFSALQQPLSSVSSSSSSSPSELDSRRLLTSSRGSTGREKNDKP 1299

Human  1378 -----LPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNSTEAERNKTRE 1437
                 :||| .||.|.:| |||||..||  |||.|||.|:||||||...:.::|:....|.|  |
 Frog  1300 SAPSSIPSA-PRPGTLLR-GSSKDSADN--QEELRRETLQTVKQLTNVAEPDKNTVPERRPK--E 1358

Human  1438 SAKPEISAMSAHDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLHVFVRVGVES 1502
            .||.|   .|..||..|||||:|||||:||||||||||:||||||||||.|.|.|.||||.||||
 Frog  1359 PAKSE---PSEPDKPTLSEEEMERKSKAIIDEFLHINDYKEAMQCVEELGANGPLSVFVRQGVES 1420

Human  1503 TLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLAELVTPMLKE 1567
            ||||||||||||||||||||||.||||.|||.|||||||||||||||||||||||||||||||||
 Frog  1421 TLERSQITRDHMGQLLYQLVQSGKLSKLDFFTGFSETLELADDMAIDIPHIWLYLAELVTPMLKE 1485

Human  1568 GGISMRELTIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALWREADLSWKDFLPEGEDVHN 1632
            ||||:|||..||.|.||||||.|.||||||||||||||||:|.|||||..|.|:|.|||||||.:
 Frog  1486 GGISLRELITEFGKALLPVGRGGELLSEILHLLCKQMSHKRVAALWRETGLRWRDLLPEGEDVQS 1550

Human  1633 FLLEQKLDFIESDSPCSSEALSKKELSAEELYKRLEKLIIEDKANDEQIFDWVEANLDEIQMSSP 1697
            |:.|:.|:|..|||...||.|||||:|||||:||||:|||::|||||||||||||:|||.|||||
 Frog  1551 FVSEKNLEFTLSDSSSPSENLSKKEMSAEELHKRLEQLIIQEKANDEQIFDWVEASLDESQMSSP 1615

Human  1698 TFLRALMTAVCKAAIIADSSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQASIVKLDQPA 1762
            |||||||||||||||:.|.|:.|||...:|||||:||||||||||:||||||||||.|||||||.
 Frog  1616 TFLRALMTAVCKAAILGDCSSCRVDITFLKQRVPVLLKYLDSDTERELQALYALQALIVKLDQPP 1680

Human  1763 NLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQNGKGVALKSVTAFFTWLREAEEESEDN 1822
            |:|||||||||||||||||||||||||||||||.||||||||||||||||:|||||||||
 Frog  1681 NVLRMFFDCLYDEEVISEDAFYKWESSKDPAEQEGKGVALKSVTAFFTWLQEAEEESEDN 1740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF4G3	XP_047289187.1	PHA03378	<74..492	CDD:223065	272/435 (63%)
		MIF4G	992..1220	CDD:397130	215/227 (95%)
		MA3	1459..1571	CDD:397128	100/111 (90%)
		W2_eIF4G1_like	1665..1793	CDD:211397	108/127 (85%)
		W2	<1772..1818	CDD:473053	43/45 (96%)
eif4g3	XP_031760741.1	PHA03247	<73..493	CDD:223021	272/463 (59%)
		MIF4G	910..1138	CDD:397130	215/227 (95%)
		MA3	1378..1489	CDD:397128	100/110 (91%)
		W2_eIF4G1_like	1579..1711	CDD:211397	111/131 (85%)
		W2	<1690..1736	CDD:473053	43/45 (96%)