Protein Alignment CBL and cbl

DIOPT Version :10

• Sequence 1: NP_005179.2
• Gene: CBL / 867
• HGNCID: 1541
• Length: 906
• Species: Homo sapiens
• Sequence 2: XP_012822121.1
• Gene: cbl / 594900
• XenbaseID: XB-GENE-6258452
• Length: 904
• Species: Xenopus tropicalis
• Alignment Length: 914
• Identity: 660/914 - (72%)
• Similarity: 718/914 - (78%)
• Gaps: 84/914 - (9%)

Human     1 MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDK 65
            ||.|::|              .||||||:||||||||||    ....||.||:|.||||||||||
 Frog    67 MATNLRK--------------GGGLIGLVKDAFQPHHHH----PTAQPGAVDRKTVEKCWKLMDK 113

Human    66 VVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTI 130
            |||||||.:||||||||||||||||||||||||:||||||||.||||||||||||||:|||||||
 Frog   114 VVRLCQNQRLALKNSPPYILDLLPDTYQHLRTIMSRYEGKMEILGENEYFRVFMENLLKKTKQTI 178

Human   131 SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFG 195
            ||||||||||||||||||||||||||||||||||||.|||:|.||||:|||||||||||||||||
 Frog   179 SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKAIFPNGQFQGDSFRITKADAAEFWRKAFG 243

Human   196 EKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNS 260
            ||||||||.||.|||:|||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   244 EKTIVPWKIFRLALHDVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNS 308

Human   261 LAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLF 325
            |||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||
 Frog   309 LAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLF 373

Human   326 QALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKD 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   374 QALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKD 438

Human   391 VKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSG--SLLRQGAEGAPSP 453
            ||||||||||||||||||||||||||||||||||||||||||||||||.|  .|||...:|.|||
 Frog   439 VKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGGGMAELLRHCMDGTPSP 503

Human   454 NYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGT 518
            .||||||:..:|::|:|||||||||||||||.|..||||||||||||||||||....|.|.:..|
 Frog   504 CYDDDDDDSGNDSIFVMKELAGAKVERPPSPLSATPQASLPPVPPRLDLLPQRAPNQSGACSPAT 568

Human   519 ASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPS 583
            :|||:|.|.||||||||||||||||||||||||:|:..||||||||||.||.:.|.     |:|:
 Frog   569 SSKASSSSHHKDKPLPVPPTLRDLPPPPPPDRPHSMPCESRPQRRPLPSTPAEKPL-----PLPT 628

Human   584 SRLGDSWLPRPIPKVPVSAPSSSDPWT-GRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLD-TS 646
            :|.|::|.||.:||.|.|..:..|||| ||||||||||||:|||.::.|.|  |.|||.||| |.
 Frog   629 NRPGETWHPRAVPKAPASNLTPGDPWTGGRELTNRHSLPFTLPSHIDERRD--RHGSTQSLDNTG 691

Human   647 MSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPL 711
            :|..:....|.:.|..|:|||||||||||||.|       ||.:|.|.|
 Frog   692 ISATTELFGGLDNDDAKMKPSSSANAIYSLATR-------PPDQQTERE---------------- 733

Human   712 DTSQSSRACDCDQQIDSCTYEAMYNIQSQA--PSITESSTFGEGNLAAAHANTGPEESENEDDGY 774
                              :||.|||||.||  |.:.|.|...|.|  :|.||.|||..:||:|||
 Frog   734 ------------------SYETMYNIQCQATNPVVVEPSREEETN--SAIANNGPENDDNEEDGY 778

Human   775 DVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKA-- 837
            |:|||.:|...||||:||..||:.:|...::..|....:.|.||||||||||||||:||||::
 Frog   779 DIPKPHLPMAPARRTMSDAPNATPAFCSGAIGRDSGAGLLESSQVPERPPKPFPRRMNSERRSVV 843

Human   838 GSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPA 902
            |.   |||.|..|     .||||||:|:|||||.||:.|||:||.||||||:|||||||||.|||
 Frog   844 GG---GSGDAPPA-----PLSSEIESLLSQGYSQQDVNKALLIAHNNIEMARNILREFVSIPSPA 900

Human   903 HVAT 906
            ||||
 Frog   901 HVAT 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBL	NP_005179.2	Sufficient for interaction with EPHB1. /evidence=ECO:0000269|PubMed:18034775	1..357		312/355 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		4/19 (21%)
		4H	47..175		115/127 (91%)
		Cbl_N	51..175	CDD:426685	113/123 (92%)
		EF-hand-like	176..248		67/71 (94%)
		Cbl_N2	179..262	CDD:460681	79/82 (96%)
		SH2-like	249..351		100/101 (99%)
		SH2_Cbl-b_TKB	256..352	CDD:198176	94/95 (99%)
		Linker	352..380		27/27 (100%)
		Required for ubiquitination of SPRED2. /evidence=ECO:0000269|PubMed:17094949	358..906		344/555 (62%)
		RING-HC_Cbl	358..434	CDD:438368	75/75 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..462		21/31 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..498		17/20 (85%)
		PHA03247	<480..810	CDD:223021	173/333 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..667		88/149 (59%)
		Interaction with CD2AP. /evidence=ECO:0000269|PubMed:11067845	648..906		127/261 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..719		5/38 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	743..781		19/37 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..854		27/56 (48%)
		UBA_c-Cbl	857..896	CDD:270576	30/38 (79%)
cbl	XP_012822121.1	Cbl_N	99..223	CDD:426685	113/123 (92%)
		Cbl_N2	227..310	CDD:460681	79/82 (96%)
		SH2_Cbl-b_TKB	304..400	CDD:198176	94/95 (99%)
		RING-HC_Cbl	406..482	CDD:438368	75/75 (100%)
		PHA03247	<526..645	CDD:223021	83/123 (67%)
		UBA_c-Cbl	855..894	CDD:270576	30/38 (79%)