Protein Alignment CBL and Cbl

DIOPT Version :10

• Sequence 1: NP_005179.2
• Gene: CBL / 867
• HGNCID: 1541
• Length: 906
• Species: Homo sapiens
• Sequence 2: NP_001406884.1
• Gene: Cbl / 500985
• RGDID: 1561386
• Length: 914
• Species: Rattus norvegicus
• Alignment Length: 916
• Identity: 843/916 - (92%)
• Similarity: 865/916 - (94%)
• Gaps: 12/916 - (1%)

Human     1 MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDK 65
            ||||||||||| |||||||||:||||||||||||||||||||||||||.||||||||||||||||
  Rat     1 MAGNVKKSSGA-GGSGSGGSGAGGLIGLMKDAFQPHHHHHHHLSPHPPCTVDKKMVEKCWKLMDK 64

Human    66 VVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTI 130
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
  Rat    65 VVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTI 129

Human   131 SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFG 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   130 SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFG 194

Human   196 EKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNS 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   195 EKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNS 259

Human   261 LAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLF 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   260 LAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLF 324

Human   326 QALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKD 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   325 QALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKD 389

Human   391 VKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNY 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   390 VKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNY 454

Human   456 DDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTAS 520
            ||||||||||:|||||||||||||||.|||||||||||||||||||||.||..||:|.|.|||||
  Rat   455 DDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRLDLLQQRAPVPASTSVLGTAS 519

Human   521 KAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSR 585
            ||:|.|||||||||:||||||||||||||||||||.|:|||||||||||||||||||||||||||
  Rat   520 KASSSSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGTETRPQRRPLPCTPGDCPSRDKLPPVPSSR 584

Human   586 LGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMN 650
            .|||||.||||||||:.|:..|||.|||||||||||||||||||||.||||||||||||||.:||
  Rat   585 PGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDTSTTMN 649

Human   651 SSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPL------- 708
            |||:.|||.:|||||||||||||||||||||||||||||||.:.|||||||||:|||:
  Rat   650 SSPVAGPESEHPKIKPSSSANAIYSLAARPLPVPKLPPGEQGDSEEDTEYMTPTSRPVGVQKPEP 714

Human   709 -RPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDD 772
             ||.:|:|||||||||||||||||||||||||||.|:.|:|..||||||.||.:|||||||||||
  Rat   715 KRPAETAQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSACGEGNLATAHTSTGPEESENEDD 779

Human   773 GYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKA 837
            |||||||||||||||||||||||||||||||||||:| ||..|||||||||||||||||||||||
  Rat   780 GYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGEP-TNFNEGSQVPERPPKPFPRRINSERKA 843

Human   838 GSCQQGSGPAA--SAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISS 900
            .|.|||.|..|  :||..|||||||||.||||||||||||||||||.||||||||||||||||||
  Rat   844 SSYQQGGGAMANPAAAAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISS 908

Human   901 PAHVAT 906
            ||||||
  Rat   909 PAHVAT 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBL	NP_005179.2	Sufficient for interaction with EPHB1. /evidence=ECO:0000269|PubMed:18034775	1..357		351/355 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		18/19 (95%)
		4H	47..175		125/127 (98%)
		Cbl_N	51..175	CDD:426685	122/123 (99%)
		EF-hand-like	176..248		71/71 (100%)
		Cbl_N2	179..262	CDD:460681	82/82 (100%)
		SH2-like	249..351		101/101 (100%)
		SH2_Cbl-b_TKB	256..352	CDD:198176	95/95 (100%)
		Linker	352..380		27/27 (100%)
		Required for ubiquitination of SPRED2. /evidence=ECO:0000269|PubMed:17094949	358..906		488/557 (88%)
		RING-HC_Cbl	358..434	CDD:438368	75/75 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..462		29/29 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..498		19/20 (95%)
		PHA03247	<480..810	CDD:223021	284/337 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..667		127/147 (86%)
		Interaction with CD2AP. /evidence=ECO:0000269|PubMed:11067845	648..906		221/267 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..719		30/46 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	743..781		29/37 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..854		43/56 (77%)
		UBA_c-Cbl	857..896	CDD:270576	36/38 (95%)
Cbl	NP_001406884.1	Cbl_N	50..174	CDD:426685	122/123 (99%)
		Cbl_N2	178..261	CDD:460681	82/82 (100%)
		SH2_Cbl-b_TKB	255..351	CDD:198176	95/95 (100%)
		RING-HC_Cbl	357..433	CDD:438368	75/75 (100%)
		PHA03247	<479..848	CDD:223021	311/369 (84%)
		UBA_c-Cbl	865..904	CDD:270576	36/38 (95%)