Protein Alignment CBL and cbl

DIOPT Version :10

• Sequence 1: NP_005179.2
• Gene: CBL / 867
• HGNCID: 1541
• Length: 906
• Species: Homo sapiens
• Sequence 2: NP_001007331.1
• Gene: cbl / 492364
• ZFINID: ZDB-GENE-041114-207
• Length: 913
• Species: Danio rerio
• Alignment Length: 945
• Identity: 659/945 - (69%)
• Similarity: 728/945 - (77%)
• Gaps: 71/945 - (7%)

Human     1 MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDK 65
            ||||:||              .|||||:||||||||||.||  |.|.||.||||.||||||.|||
Zfish     1 MAGNLKK--------------GGGLIGMMKDAFQPHHHLHH--SHHQPGAVDKKTVEKCWKFMDK 49

Human    66 VVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTI 130
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||.|||||||
Zfish    50 VVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGDNEYFRVFMENLTKKTKQTI 114

Human   131 SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFG 195
            ||||:|||||:|||||||||||||||||||||||||.|||:||||||.|||||||||||||::||
Zfish   115 SLFKDGKERMFEENSQPRRNLTKLSLIFSHMLAELKAIFPNGLFQGDNFRITKADAAEFWRRSFG 179

Human   196 EKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNS 260
            :|||||||.|||||||.||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   180 DKTIVPWKVFRQALHEFHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNS 244

Human   261 LAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLF 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   245 LAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLF 309

Human   326 QALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKD 390
            ||.|||||||||||||||.|||||||||||:||||||||||||||||||||||||||||||||||
Zfish   310 QAHIDGFREGFYLFPDGRTQNPDLTGLCEPSPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKD 374

Human   391 VKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQ------GAEG 449
            ||||||||||||||||:|||||||||||||||||||||||||||||:...|....      ||||
Zfish   375 VKIEPCGHLMCTSCLTAWQESEGQGCPFCRCEIKGTEPIVVDPFDPKDPNSAASYGCRGMFGAEG 439

Human   450 APSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSAS 514
            ||||:||||||:|.::|.||:.:|.|:||||||||.|::||..:|||||||||||.|...|..||
Zfish   440 APSPSYDDDDDDRLEETPFMISKLVGSKVERPPSPMSISPQPVVPPVPPRLDLLPLRPTNPPGAS 504

Human   515 ALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLP 579
            :.|..|||.|.  |||||||:||.|||||||||||||:..||::|..|||||.|||| |||||||
Zfish   505 SPGATSKAPSH--HKDKPLPLPPALRDLPPPPPPDRPHPAGADNRLPRRPLPSTPGD-PSRDKLP 566

Human   580 PVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLD 644
            |.|.:|....|..||:||.|...|:|.|....|||:||||||..|||.::.|.:.||.....|||
Zfish   567 PAPPNRNMPDWNSRPVPKAPSQPPASGDTRGSRELSNRHSLPLQLPSTLDSRTEAPRNNGPPSLD 631

Human   645 TSMSMNSSPLVGPECDH--PKIKPSSSANAIYSLAARPLPVPKLPPGEQC-EGEEDTEYMTPSSR 706
            ..:|..||   .|..|:  ||:|||:|||||||||.||:...:...||:. |.:|::||||||||
Zfish   632 HQLSFGSS---NPASDYDSPKVKPSASANAIYSLAIRPVAAARTQTGEETNENDEESEYMTPSSR 693

Human   707 PL-------------RPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITES------STFGE 752
            |:             .||..|..|...:.:.:... .||||||||:||  :|.|      |.:.|
Zfish   694 PVLPSAAGEAVPRPPPPLSLSPRSMLNELESESPQ-MYEAMYNIQAQA--LTASAPQARDSDYSE 755

Human   753 GNLAAAHANTGP--------EESENEDDGYDVPKPPVPAVLARRTLSDISNASSS-FGWLSLDGD 808
              |.....:.||        ||.|.|::.||.|||.:.|.||||||||.::.||| |..||.|.|
Zfish   756 --LPPLTCSNGPRDPVGAYAEEEEEEENSYDYPKPHLSAALARRTLSDANSPSSSAFSRLSFDSD 818

Human   809 --PTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSY 871
              ....|.:.|:.|||||||.||||||:|:......|:.|.     .|.|:|||||:|:|||||:
Zfish   819 LGAAATVLDPSEAPERPPKPLPRRINSDRRPSPVPPGASPG-----PSQQISSEIEHLLSQGYSH 878

Human   872 QDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT 906
            |||||||:|||||||||||:|||||||.|.||:.|
Zfish   879 QDIQKALMIAQNNIEMAKNVLREFVSIPSTAHILT 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBL	NP_005179.2	Sufficient for interaction with EPHB1. /evidence=ECO:0000269|PubMed:18034775	1..357		316/355 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		6/19 (32%)
		4H	47..175		117/127 (92%)
		Cbl_N	51..175	CDD:426685	115/123 (93%)
		EF-hand-like	176..248		65/71 (92%)
		Cbl_N2	179..262	CDD:460681	77/82 (94%)
		SH2-like	249..351		99/101 (98%)
		SH2_Cbl-b_TKB	256..352	CDD:198176	93/95 (98%)
		Linker	352..380		26/27 (96%)
		Required for ubiquitination of SPRED2. /evidence=ECO:0000269|PubMed:17094949	358..906		341/586 (58%)
		RING-HC_Cbl	358..434	CDD:438368	74/75 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..462		20/35 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..498		14/20 (70%)
		PHA03247	<480..810	CDD:223021	180/362 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..667		83/149 (56%)
		Interaction with CD2AP. /evidence=ECO:0000269|PubMed:11067845	648..906		140/290 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..719		18/52 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	743..781		16/51 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..854		24/57 (42%)
		UBA_c-Cbl	857..896	CDD:270576	32/38 (84%)
cbl	NP_001007331.1	Cbl_N	35..159	CDD:426685	115/123 (93%)
		Cbl_N2	163..246	CDD:460681	77/82 (94%)
		SH2_Cbl-b_TKB	240..336	CDD:198176	93/95 (98%)
		RING-HC_Cbl	342..418	CDD:438368	74/75 (99%)
		PHA03247	<494..851	CDD:223021	178/367 (49%)
		UBA_c-Cbl	864..903	CDD:270576	32/38 (84%)