DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CBL and Cbl

DIOPT Version :10

Sequence 1:NP_005179.2 Gene:CBL / 867 HGNCID:1541 Length:906 Species:Homo sapiens
Sequence 2:NP_648224.1 Gene:Cbl / 38961 FlyBaseID:FBgn0020224 Length:878 Species:Drosophila melanogaster


Alignment Length:950 Identity:413/950 - (43%)
Similarity:518/950 - (54%) Gaps:209/950 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    50 TVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEY 114
            :.|||.:||.||||||||:|||.||:.||||||:|||:||||||.||.|.|:.|.:|..|..||:
  Fly    38 STDKKTLEKTWKLMDKVVKLCQQPKMNLKNSPPFILDILPDTYQRLRLIYSKNEDQMHLLHANEH 102

Human   115 FRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTF 179
            |.||:.|||:|.||.|.|||||||:|::|||..|||||||||:|||||:|||.|||:|:|.||.|
  Fly   103 FNVFINNLMRKCKQAIKLFKEGKEKMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQF 167

Human   180 RITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIF 244
            ||||||||:||:..||..|:||||.|||.|::||||.|||||||||:||||||||:||.||||:|
  Fly   168 RITKADAADFWKSNFGNSTLVPWKIFRQELNKVHPIISGLEAMALKTTIDLTCNDFISNFEFDVF 232

Human   245 TRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVT 309
            |||||||.:|||||..||||||||:|||||||||||||::|.|.|||:|||||||||||||||||
  Fly   233 TRLFQPWVTLLRNWQILAVTHPGYVAFLTYDEVKARLQRYILKAGSYVFRLSCTRLGQWAIGYVT 297

Human   310 ADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEM 374
            |:|.||||||.||.|.|||:||.||||||:|||:..||||:...:...:|||.||||||||||||
  Fly   298 AEGEILQTIPQNKSLCQALLDGHREGFYLYPDGQAYNPDLSSAVQSPTEDHITVTQEQYELYCEM 362

Human   375 GSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQ-ESEGQGCPFCRCEIKGTEPIVVDPFDPRG 438
            ||||||||||||||||::|||||||:||.|||||| :||||||||||.||||||.||||.||||.
  Fly   363 GSTFQLCKICAENDKDIRIEPCGHLLCTPCLTSWQVDSEGQGCPFCRAEIKGTEQIVVDAFDPRK 427

Human   439 SGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRL--- 500
            ..:  |....|......:||.::..|      ..:|.:.:....:..::|.:...|...|||   
  Fly   428 QHN--RNVTNGRQQQQEEDDTEDIGD------FNIATSSLHALSTSSTVAAEKHSPHTSPRLGRR 484

Human   501 -----------DL----LPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDR 550
                       ||    .|......||.|::..||.::|.||.....:                 
  Fly   485 STTPSLMAVQNDLYAGGTPTLSLPSSSCSSIAAASTSSSSSLASVATV----------------- 532

Human   551 PYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTG---- 611
              :....|...::|.|..|                             |.||..|:....|    
  Fly   533 --AASTSSSQHQQPQPSAP-----------------------------PASAVLSNGGGGGGGGG 566

Human   612 ----RELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDT---SMSMNSSPLVGPECDHPKIKPSS- 668
                ::.|||.|.|.              :||..:..|   .:..|        |.|.....|| 
  Fly   567 ASSSQKNTNRMSAPL--------------IGSCVANSTYGQKLPQN--------CSHSSTSSSSD 609

Human   669 --SANAIYSL-----------AARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRAC 720
              |:::.|::           .|..:..|.|||.:...|.|     |||.....|..:|..|   
  Fly   610 NASSSSSYAILQNLHDTGTPATAAAVVAPPLPPRKSSPGVE-----TPSKATAPPPPSSSKS--- 666

Human   721 DCDQQIDS--CTYEAMYNI--QSQAPSITESSTFGEGNLA--------AAHANTGPEESENEDDG 773
                 ||:  |:.:   |:  |:.||.|....:.....||        .|.:.|.|..|..::|.
  Fly   667 -----IDNIQCSLD---NVPPQTTAPPIPPHVSPSVDTLAEDLMRQQLIATSTTSPVLSLLDEDI 723

Human   774 YDV-PKPPVPAVLARR-------TLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRR 830
            .:| |...:..|:..|       ||....:|||.:..|      .|..:.||..          .
  Fly   724 VEVGPAETISGVIDTRPLEARGVTLCRQDSASSHYTQL------CTTSSGGSAA----------A 772

Human   831 INSERKAGSCQQG-----SGPAASAATA----SPQLSSE-------------------------- 860
            :.:.:||.|.:|.     :..||:||||    :|...|:                          
  Fly   773 LANGKKANSAKQSQATTTTSAAAAAATAGNGSNPGQQSQPLLYANVTINQKDCGTVPYENINLEY 837

Human   861 IENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISS 900
            |..||:.|||.::...||.|::||||||.:|||||||.:|
  Fly   838 IARLMNAGYSKENAITALGISRNNIEMAGDILREFVSKNS 877

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CBLNP_005179.2 Sufficient for interaction with EPHB1. /evidence=ECO:0000269|PubMed:18034775 1..357 221/306 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
4H 47..175 84/124 (68%)
Cbl_N 51..175 CDD:426685 84/123 (68%)
EF-hand-like 176..248 54/71 (76%)
Cbl_N2 179..262 CDD:460681 62/82 (76%)
SH2-like 249..351 80/101 (79%)
SH2_Cbl-b_TKB 256..352 CDD:198176 75/95 (79%)
Linker 352..380 19/27 (70%)
Required for ubiquitination of SPRED2. /evidence=ECO:0000269|PubMed:17094949 358..906 191/641 (30%)
RING-HC_Cbl 358..434 CDD:438368 66/76 (87%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 432..462 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..498 2/20 (10%)
PHA03247 <480..810 CDD:223021 78/392 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 519..667 25/158 (16%)
Interaction with CD2AP. /evidence=ECO:0000269|PubMed:11067845 648..906 82/321 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..719 12/38 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 743..781 10/46 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 799..854 14/63 (22%)
UBA_c-Cbl 857..896 CDD:270576 20/64 (31%)
CblNP_648224.1 Cbl_N 40..163 CDD:426685 84/122 (69%)
Cbl_N2 167..250 CDD:460681 62/82 (76%)
SH2_Cbl-b_TKB 244..340 CDD:198176 75/95 (79%)
RING-HC_Cbl 346..423 CDD:438368 66/76 (87%)
COG5222 <368..503 CDD:227547 63/142 (44%)
UBA_Cbl_like 834..873 CDD:270503 19/38 (50%)
Blue background indicates that the domain is not in the aligned region.

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