Protein Alignment CBL and sli-1

DIOPT Version :10

• Sequence 1: NP_005179.2
• Gene: CBL / 867
• HGNCID: 1541
• Length: 906
• Species: Homo sapiens
• Sequence 2: NP_508145.2
• Gene: sli-1 / 180419
• WormBaseID: WBGene00004829
• Length: 582
• Species: Caenorhabditis elegans
• Alignment Length: 231
• Identity: 42/231 - (18%)
• Similarity: 82/231 - (35%)
• Gaps: 80/231 - (34%)

Human   681 LLPKSQATAHELRY-QVPGAVPAKV--QLLRSAAD----WSAGIKHHEESIHAAYIHVIENSKHY 738
            |:|  :.|.|.|.| ..|......:  .|:|.||:    |.| :.|.:.::....|..:...|.|
 Worm    40 LVP--EITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKA-LYHKDFTLEQDGITPVNGWKEY 101

Human   739 -------IYIENQFFISCADDKVVFNKVGDAIAQRILKA------HREGQRYRVY--------IV 782
                   |.:..:||      .::.::...|:|:..|.:      |..|:.:..|        :.
 Worm   102 YATTRAIISVNTEFF------TIIRDRALQAMARLWLNSDYVKCIHASGELFSGYNEVIQSWQLC 160

Human   783 IPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGESSILEQLKPELGNKWINYISFCGLRTHAELE 847
            .....||:..:.|             .||      .||..:      .|:.      ::.:..::
 Worm   161 FNWEQGFDFQVHT-------------VRT------RILTDM------AWVT------MKAYLNVD 194

Human   848 GN--LVT----------ELIYVHSKLLIADDNTVII 871
            |.  |:|          .:::.||.:::.||..|::
 Worm   195 GGPFLITNVFEFHNGRWHMVHHHSSVMLIDDQQVVV 230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBL	NP_005179.2	Sufficient for interaction with EPHB1. /evidence=ECO:0000269|PubMed:18034775	1..357
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		4H	47..175
		Cbl_N	51..175	CDD:426685
		EF-hand-like	176..248
		Cbl_N2	179..262	CDD:460681
		SH2-like	249..351
		SH2_Cbl-b_TKB	256..352	CDD:198176
		Linker	352..380
		Required for ubiquitination of SPRED2. /evidence=ECO:0000269|PubMed:17094949	358..906		42/231 (18%)
		RING-HC_Cbl	358..434	CDD:438368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..462
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..498
		PHA03247	<480..810	CDD:223021	29/156 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..667
		Interaction with CD2AP. /evidence=ECO:0000269|PubMed:11067845	648..906		42/231 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..719		13/44 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	743..781		8/51 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..854		8/66 (12%)
		UBA_c-Cbl	857..896	CDD:270576	5/15 (33%)
sli-1	NP_508145.2	Cbl_N	64..183	CDD:426685	26/150 (17%)
		Cbl_N2	187..271	CDD:460681	8/44 (18%)
		SH2_Cbl-b_TKB	265..361	CDD:198176
		RING_Ubox	368..445	CDD:473075