Protein Alignment CBL and Cbl

DIOPT Version :10

• Sequence 1: NP_005179.2
• Gene: CBL / 867
• HGNCID: 1541
• Length: 906
• Species: Homo sapiens
• Sequence 2: NP_031645.2
• Gene: Cbl / 12402
• MGIID: 88279
• Length: 913
• Species: Mus musculus
• Alignment Length: 916
• Identity: 848/916 - (92%)
• Similarity: 868/916 - (94%)
• Gaps: 13/916 - (1%)

Human     1 MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDK 65
            |||||||||||||| ||||||:||||||||||||| ||||||||||||.||||||||||||||||
Mouse     1 MAGNVKKSSGAGGG-GSGGSGAGGLIGLMKDAFQP-HHHHHHLSPHPPCTVDKKMVEKCWKLMDK 63

Human    66 VVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTI 130
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Mouse    64 VVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTI 128

Human   131 SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFG 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   129 SLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFG 193

Human   196 EKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNS 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   194 EKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNS 258

Human   261 LAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLF 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   259 LAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLF 323

Human   326 QALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKD 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   324 QALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKD 388

Human   391 VKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNY 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   389 VKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNY 453

Human   456 DDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTAS 520
            ||||||||||:|||||||||||||||.|||||||||||||||||||||.||..||:|.|.|||||
Mouse   454 DDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRLDLLQQRAPVPASTSVLGTAS 518

Human   521 KAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSR 585
            ||||||||||||||:||||||||||||||||||||||:|||||||||||||||||||||||||||
Mouse   519 KAASGSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGAETRPQRRPLPCTPGDCPSRDKLPPVPSSR 583

Human   586 LGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMN 650
            .|||||.||||||||:.|:..|||.|||||||||||||||||||||.|||||||||||||||:||
Mouse   584 PGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDTSMTMN 648

Human   651 SSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPL------- 708
            |||:.|||.:||||||||||||||||||||||:||||||||.|.|||||||||:|||:
Mouse   649 SSPVAGPESEHPKIKPSSSANAIYSLAARPLPMPKLPPGEQGESEEDTEYMTPTSRPVGVQKPEP 713

Human   709 -RPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDD 772
             |||:.:|||||||||||||||||||||||||||.|:.|:|..||||||.||.:|||||||||||
Mouse   714 KRPLEATQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSASGEGNLATAHTSTGPEESENEDD 778

Human   773 GYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKA 837
            ||||||||||||||||||||||||||||||||||||| ||..|||||||||||||||||||||||
Mouse   779 GYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDP-TNFNEGSQVPERPPKPFPRRINSERKA 842

Human   838 GSCQQGSGPAAS-AATA-SPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISS 900
            .|.|||.|..|: .||| |||||||||.||||||||||||||||||.||||||||||||||||||
Mouse   843 SSYQQGGGATANPVATAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISS 907

Human   901 PAHVAT 906
            ||||||
Mouse   908 PAHVAT 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBL	NP_005179.2	Sufficient for interaction with EPHB1. /evidence=ECO:0000269|PubMed:18034775	1..357		350/355 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		18/19 (95%)
		4H	47..175		125/127 (98%)
		Cbl_N	51..175	CDD:426685	122/123 (99%)
		EF-hand-like	176..248		71/71 (100%)
		Cbl_N2	179..262	CDD:460681	82/82 (100%)
		SH2-like	249..351		101/101 (100%)
		SH2_Cbl-b_TKB	256..352	CDD:198176	95/95 (100%)
		Linker	352..380		27/27 (100%)
		Required for ubiquitination of SPRED2. /evidence=ECO:0000269|PubMed:17094949	358..906		494/557 (89%)
		RING-HC_Cbl	358..434	CDD:438368	75/75 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..462		29/29 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..498		19/20 (95%)
		PHA03247	<480..810	CDD:223021	289/337 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..667		131/147 (89%)
		Interaction with CD2AP. /evidence=ECO:0000269|PubMed:11067845	648..906		223/267 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..719		30/46 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	743..781		29/37 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..854		45/56 (80%)
		UBA_c-Cbl	857..896	CDD:270576	36/38 (95%)
Cbl	NP_031645.2	Sufficient for interaction with EPHB1. /evidence=ECO:0000269|PubMed:18034775	1..355		350/355 (99%)
		4H	45..173		125/127 (98%)
		Cbl_N	49..173	CDD:426685	122/123 (99%)
		EF-hand-like	174..246		71/71 (100%)
		Cbl_N2	177..260	CDD:460681	82/82 (100%)
		SH2-like	247..349		101/101 (100%)
		SH2_Cbl-b_TKB	254..350	CDD:198176	95/95 (100%)
		Linker	350..378		27/27 (100%)
		Required for ubiquitination of SPRED2. /evidence=ECO:0000250|UniProtKB:P22681	356..913		494/557 (89%)
		RING-HC_Cbl	356..432	CDD:438368	75/75 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..460		29/29 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..613		119/136 (88%)
		PHA03247	<478..849	CDD:223021	318/371 (86%)
		Interaction with CD2AP. /evidence=ECO:0000250	646..913		223/267 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	647..727		59/79 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	750..787		28/36 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	814..863		37/49 (76%)
		UBA_c-Cbl	864..903	CDD:270576	36/38 (95%)