DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EIF3G and TIF35

DIOPT Version :9

Sequence 1:	NP_003746.2	Gene:	EIF3G / 8666	HGNCID:	3274	Length:	320	Species:	Homo sapiens
Sequence 2:	NP_010717.1	Gene:	TIF35 / 852039	SGDID:	S000002837	Length:	274	Species:	Saccharomyces cerevisiae

Alignment Length:	275	Identity:	92/275 - (33%)
Similarity:	149/275 - (54%)	Gaps:	23/275 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    56 PKEVING--NIKTVTEYKIDEDGKKFKI---VRTFRIETRKASKAVARRKNWKKFGNSEFDPPGP 115
            |:|:|..  ..:::..||| |||.|:||   |:..:: ..|..|:||.||||.|:|:.:..|.||
Yeast     6 PEEIIENADGSRSIITYKI-EDGVKYKITQKVKEVKV-LEKVHKSVAERKNWHKYGSEKGSPAGP 68

Human   116 NVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKI---VSCRICKGDHWTTRCPYK---DT 174
            :..|..:.::|.:....:.:    |.||:.:.|.|....   :.||:|..||.|..||:|   ..
Yeast    69 SAVTARLGEEVELRLSRNWK----QAEEERIQKEKASLTKTGLQCRLCGNDHMTMNCPFKTILSE 129

Human   175 LGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGA-SRRGESMQPNRRADDN 238
            |..::.....:.|:....:|| .|:   |....:..|:|||||.|.|| ....::.:.:|..||.
Yeast   130 LSALEDPATNEGGVEAASEEK-AGQ---VGGAGSIPGQYVPPSRRAGARDPSSDAYRDSRERDDM 190

Human   239 ATIRVTNLSEDTRETDL-QELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSG 302
            .|:::..::|:..|..| :||..||..|.|:.:.::|.||:|:|.||::|...|.|.:|:..:.|
Yeast   191 CTLKIMQVNENADENSLREELLFPFAPIPRVSVVRNKETGKSRGLAFVTFSSEEVAEQALRFLDG 255

Human   303 FGYDHLILNVEWAKP 317
            .||.:|||.|||:||
Yeast   256 RGYMNLILRVEWSKP 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EIF3G	NP_003746.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		1/2 (50%)
		eIF3G	62..173	CDD:240597	39/121 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..234		9/25 (36%)
		RRM_eIF3G_like	240..315	CDD:409842	29/75 (39%)
TIF35	NP_010717.1	eIF3g	6..127	CDD:403535	42/126 (33%)
TIF35	NP_010717.1	RRM_eIF3G_like	192..268	CDD:409842	29/75 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159049495
Domainoid	1	1.000	68	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG0122
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2784
Inparanoid	1	1.050	144	1.000	Inparanoid score	I1293
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55427
OrthoFinder	1	1.000	-	-		FOG0003558
OrthoInspector	1	1.000	-	-		oto145613
orthoMCL	1	0.900	-	-		OOG6_102687
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R382
SonicParanoid	1	1.000	-	-		X2433
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.830