Protein Alignment EIF3G and eIF3g2

DIOPT Version :10

• Sequence 1: NP_003746.2
• Gene: EIF3G / 8666
• HGNCID: 3274
• Length: 320
• Species: Homo sapiens
• Sequence 2: NP_650887.1
• Gene: eIF3g2 / 42422
• FlyBaseID: FBgn0038796
• Length: 273
• Species: Drosophila melanogaster
• Alignment Length: 309
• Identity: 128/309 - (41%)
• Similarity: 175/309 - (56%)
• Gaps: 46/309 - (14%)

Human    11 SWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDED 75
            ||||:|:.:..|.                             |||..|.|.|:.|.|||||.::|
  Fly     7 SWADEVDADYVDG-----------------------------LPPSNEYIKGDFKYVTEYKFNDD 42

Human    76 GKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKE-DLNC 139
            |||.|:||||:||.:...||||||:||.|||:|..|.||||..||..|:::.|.||.||: |...
  Fly    43 GKKVKVVRTFKIEKQIVPKAVARRRNWVKFGDSRSDKPGPNSQTTMASEEIFMQFIGSKDFDQTH 107

Human   140 QEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQ 204
            :.:.||     |:.|..||||.|:||:..||||.|          .:...|..:.|.........
  Fly   108 ETQLDP-----GKNIAKCRICNGEHWSVNCPYKGT----------SMDSKTVMETKANAAAAAAI 157

Human   205 ATQNKTGKYVPPSLRDGASRRG-ESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRI 268
            :..:||||||||.::||....| ::....|..||::.:|::||||...||||:||.:..|..:::
  Fly   158 SDPSKTGKYVPPFMKDGGGISGSKNWGRGRDRDDSSAVRISNLSESMTETDLEELVKKIGPHTKM 222

Human   269 YLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKP 317
            |||::|.:|..||||::.|..|:|||.||..::|.|||||||.|||:||
  Fly   223 YLAREKNSGLCKGFAYVHFKFRQDAAAAIEVLNGHGYDHLILCVEWSKP 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF3G	NP_003746.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		9/47 (19%)
		eIF3G	62..173	CDD:240597	58/111 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	209..234		11/25 (44%)
		RRM_eIF3G_like	240..315	CDD:409842	38/74 (51%)
eIF3g2	NP_650887.1	eIF3g	28..137	CDD:463545	59/113 (52%)
		RRM_eIF3G_like	195..269	CDD:409842	38/73 (52%)