Protein Alignment EIF3C and eIF3c

DIOPT Version :10

• Sequence 1: NP_003743.1
• Gene: EIF3C / 8663
• HGNCID: 3279
• Length: 913
• Species: Homo sapiens
• Sequence 2: NP_611242.1
• Gene: eIF3c / 37005
• FlyBaseID: FBgn0034258
• Length: 910
• Species: Drosophila melanogaster
• Alignment Length: 939
• Identity: 479/939 - (51%)
• Similarity: 630/939 - (67%)
• Gaps: 67/939 - (7%)

Human     1 MSRFFTTGSDSESESSLSGEELVTKPVGGNYGK-QPLLLSEDEEDTKRVVRSAKDKRFEELTNLI 64
            |||||..||:||||||   ||.:.   ..|:.| .....|:|||:.||||||.|:||:|.||::|
  Fly     1 MSRFFANGSESESESS---EEEIQ---ATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTSII 59

Human    65 RTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKE--GV-PRFYIRILADLEDYLNELWEDKEG 126
            :||||..||:|:...|..||.|.:||.||..::.||  |: ||||||.||:|||::||:|||:||
  Fly    60 KTIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREG 124

Human   127 KKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGV 191
            :|.::|||:|:|.|||||:|||.:|||..::.:::.|:|.::.:.|....:|:|....|:.:.||
  Fly   125 RKNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVALESDGGDAGDDSDAGV 189

Human   192 SAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRF 256
                   |.:||.....:....|....|:|  ||:|..|||:.| .|:::|.::|.:...:..||
  Fly   190 -------KPTEAVPKAVKSAPAKAAPADDD--DSDDSIDWDSDS-ESETESSDDENQYQNMRERF 244

Human   257 LKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKG 321
            ||:  ||::     |:|.:||.|.|...:..::.:..||:|.||||.|..|  .|.||||||.|.
  Fly   245 LKR--TTEK-----EEKDDDKRKDKRKEQKTKIRKRAEDDEDGEWETVVKG--HVVEKPKMFEKD 300

Human   322 TEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIKFNIIASLYDYN 386
            .||...:|:.||.||:.|||||.|||..||:||..|..|:.::|||..|.|||.||||:::||||
  Fly   301 AEIDVPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDYN 365

Human   387 PNLATYMKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVERM 451
            ..::..||.|.|...|:.:..:|.:|.||.:|.:.|::.||.|..  |..|..||||.|..|||:
  Fly   366 QKISEPMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEY--ATSPFYVRGCPLAAVERL 428

Human   452 DEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDY 516
            |:||.|:::..||||.:||..||||..|...||.|.:|.|..||..|.|||||.:|.|.|||||
  Fly   429 DDEFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFERSGTNNERCRIYLRKIEHLYYKFD- 492

Human   517 KAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSR 581
                     || ..|.::.:.......|..:|::|||:|||||.||||||.|||.||||||:|..
  Fly   493 ---------PE-VLKKKRGELPATTSTSVDVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHDN 547

Human   582 WYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELL 646
            |:|||||:|||||||||..|||..:|||||.|..||:||||||..||||:.|:|:..:|:.||||
  Fly   548 WFQARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKELL 612

Human   647 GQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMIS 711
            .||||.:...||:.||||:|::||:|||:||||||||||||||||||||||:||||.||||||||
  Fly   613 AQGLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMIS 677

Human   712 KQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVR 776
            |.|:.|||..|||.|:|||||||||||||:|||:.|:|:.|.:||:|:|||.||||||.|:|:||
  Fly   678 KTFYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRVR 742

Human   777 TMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQT 841
            .||.:.|:||||||||||||:||.|||:.:|:.|:||.:|.|||||||||||||||||||.|::|
  Fly   743 EMLTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSET 807

Human   842 VVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTY---------------------GGYF 885
            |.|||:||:..|.||:|..:|:.:||:.||:|||.|||.:                     ||.:
  Fly   808 VGMHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRGDRGYNRNQNNQGGNW 872

Human   886 ----RDQKDGYRKNEGYMRRGGYRQQQSQ 910
                ||:.:..|...|:.:....||||.|
  Fly   873 LGQRRDRNNRNRNQRGHHKNNQDRQQQQQ 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF3C	NP_003743.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		20/43 (47%)
		eIF-3c_N	29..705	CDD:428482	334/679 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..301		40/143 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..542		3/19 (16%)
		PINT	778..866	CDD:214509	57/87 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	885..913		9/30 (30%)
eIF3c	NP_611242.1	eIF-3c_N	24..671	CDD:428482	334/678 (49%)
		PINT	744..823	CDD:214509	54/78 (69%)